Screening for vaginal shedding of cytomegalovirus in healthy pregnant women using real-time PGR: Correlation of CMV in the vagina and adverse outcome of pregnancy

Journal of Medical Virology

Volumn 78, Issue 6, 2006, Pages 757-759

  Tanaka, Kaori ^a   Yamada, Hideto ^b   Minami, Mashiho ^b   Kataoka, Soromon ^b   Numazaki, Kei ^c   Minakami, Hisanori ^b   Tsutsumi, Hiroyuki ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

Cytomegalovirus; Miscarriage; Pregnancy; Real time PCR; Vaginal swab

Indexed keywords

VIRUS DNA;

ADULT; ARTICLE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DISEASE PREDISPOSITION; FEMALE; GENITAL TRACT INFECTION; HUMAN; JAPAN; LATENT VIRUS INFECTION; MAJOR CLINICAL STUDY; NONHUMAN; PREGNANCY COMPLICATION; REAL TIME POLYMERASE CHAIN REACTION; SPONTANEOUS ABORTION; VAGINITIS; VIRUS CARRIER; VIRUS DETECTION; VIRUS SHEDDING;

ABORTION, SPONTANEOUS; ADULT; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; FEMALE; HUMANS; POLYMERASE CHAIN REACTION; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY OUTCOME; VAGINA; VIRUS SHEDDING;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; DNA VIRUSES;

EID: 33646475597     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.20619     Document Type: Article

References (22)

1. Burguete T, Rabreau M, Fontanges-Darriet M, Roset E, Hager HD, Koppel A, Bischof P, Schlehofer JR. 1999. Evidence for infection of the human embryo with adeno-associated virus in pregnancy. Hum Reprod 14:2396-2401.
2. Clarke LM, Duerr A, Feldman J, Sierra MF, Daidone BJ, Landesman SH. 1996. Factors associated with cytomegalovirus infection among human immunodeficiency virus type 1-seronegative and-seropositive women from an urban minority community. J Infect Dis 173: 77-82.
3. Hlarke LM, Duerr A, Young KH, Brockman S, Barbosa C, Macasaet M. 1997. Recovery of cytomegalovirus and herpes simplex virus from upper and lower genital tract specimens obtained from women with pelvic inflammatory disease. J Infect Dis 176:286-288.
4. Collier AC, Handsfield HH, Ashley R, Roberts PL, DeRouen T, Meyers JD, Corey L. 1995. Cervical but not urinary excretion of cytomegalovirus is related to sexual activity and contraceptive practices in sexually active women. J Infect Dis 171:133-138.
5. Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML. 1997. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 7:273-282.
6. Dehner LP, Askin FB. 1975. Cytomegalovirus endometritis: Report of a case associated with spontaneous abortion. Obstet Gynec 45:211-214.
7. Demmler GJ. 2004. Cytomegalovirus. In: Feigin RD, Cherry JD, Demmler GJ, Kaplan SL, editors. Textbook of pediatric infectious diseases, 5th edition. Philadelphia, PA: Saunders. pp 1912-1932.
8. Gradilone A, Vercillo R, Napolitano M, Cardinali G, Gazzaniga P, Silvestri I, Gandini O, Tomao S, Agliano AM. 1996. Prevalence of human papillomavirus, cytomegalovirus, and Epstein-Barr virus in the cervix of healthy women. J Med Virol 50:1-4.
9. Handsfield HH, Chandler SH, Caine VA, Meyers JD, Corey L, Mederios E, McDougall JK. 1985. Cytomegalovirus infection in sex partners: Evidence for sexual transmission. J Infect Dis 151:344-348.
10. Ho M. 1990. Epidemiology of cytomegalovirus infections. Rev Infect Dis 12:701-710.
11. Kriel RL, Gates GA, Wulff H, Powell N, Poland JD, Chin TDY. 1970. Cytomegalovirus isolations associated with pregnancy wastage. Am J Obstet Gynecol 106:885-892.
12. Li H, Dummer JS, Estes WR, Meng S, Wright PF, Tang YW. 2003. Measurement of human cytomegalovirus loads by quantitative real-time PCR for monitoring clinical intervention in transplant recipients. J Clin Microbiol 41:187-191.
13. Manavi M, Czerwenka KF, Schurz B, Knogler W, Kubista E, Reinold E. 1992. Latent cervical virus infection as a possible cause of early abortion (Article in German). Gynaek Geburtshilf Rdsch 32:84-87.
14. Markel G, Wolf D, Hanna J, Gazit R, Goldman-Wohl D, Lavy Y, Yagel S, Mandelboim O. 2002. Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions. J Clin Invest 110:943-953.
15. Mostad SB, Kreiss JK, Ryncarz A, Chohan B, Mandaliya K, Ndinya-Achol J, Bwayo J, Corey L. 2000. Cervical shedding of herpes simplex virus and cytomegalovirus throughout the menstrual cycle in women infected with human immunodeficiency virus type 1. Am J Obstet Gynecol 183:948-955.
16. Murph JR, Souza IE, Dawson JK, Benson P, Petheram SJ, Pfab D, Gregg A, O'Neill NE, Zimmerman B, Bale JF Jr. 1998. Epidemiology of congenital cytomegalovirus infection: maternal risk factors and molecular analysis cytomegalovirus strains. Am J Epidemiol 147:940-947.
17. Numazaki K, Fujikawa T. 2002. Prevalence of serum antibodies to cytomegalovirus in pregnant women in Sapporo, Japan. Int J Infect Dis 6:147-148.
18. Shen CY, Chang SF, Yen MS, Ng HT, Huang ES, Wu CW. 1993. Cytomegalovirus excretion in pregnant and nonpregnant women. J Clin Micribiol 31:1635-1636.
19. Shen CY, Chang SF, Lin HJ, Ho HN, Yeh TS, Yang SL, Huang ES, Wu CW. 1994. Cervical cytomegalovirus infection in prostitutes and in women attending a sexually transmitted disease clinic. J Med Virol 3:362-366.
20. Tomasec P, Wang EC, Davison AJ, Vojtesek B, Armstrong M, Griffin C, McSharry BP, Morris RJ, Lewellyn-Lacey S, Rickards C, Nomoto A, Sinzger C, Wilkinson GW. 2005. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nat Immunol 6:181-188.
21. Yamamoto-Tabata T, McDonagh S, Chang HT, Fisher S, Pereira L. 2004. Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro. J Virol 78: 2831-2840.
22. Yuan CF, Kao SM, Wang DC, Pao CC. 1990. Detection of human cytomegalovirus in cervicovaginal cells by culture, in situ DNA hybridization and DNA amplification methods. Mol Cell Probes 4: 475-483.