Oral vaccine that breaks the transmission cycle of the Lyme disease spirochete can be delivered via bait

Vaccine

Volumn 24, Issue 20, 2006, Pages 4440-4449

  Gomes Solecki, Maria J C ^a,b   Brisson, Dustin R ^c   Dattwyler, Raymond J ^a,b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b Biopeptides Corp   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

Lyme; Oral; Vaccine

Indexed keywords

BACTERIAL VACCINE; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; LYME DISEASE VACCINE; OUTER SURFACE PROTEIN A;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY RESPONSE; ARTHROPOD; ARTICLE; BACTERIAL IMMUNITY; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BORRELIA BURGDORFERI; BORRELIA INFECTION; CONTROLLED STUDY; DISEASE CARRIER; DRUG DELIVERY SYSTEM; EXPERIMENTAL INFECTION; FEEDING; FEMALE; HOST; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; IMMUNOPROPHYLAXIS; INFECTION CONTROL; IXODES SCAPULARIS; LYME DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPIROCHETE; TICK; VACCINATION; VECTOR CONTROL; WILDLIFE; ZOONOSIS;

ADMINISTRATION, ORAL; ANIMALS; BACTERIAL VACCINES; BASE SEQUENCE; BORRELIA BURGDORFERI; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; HUMANS; LYME DISEASE; MICE; MICE, INBRED C3H;

EID: 33646471963     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2005.08.089     Document Type: Article

References (53)

1. Dolan M.C., Maupin G.O., Schneider B.S., Denatale C., Hamon N., Cole C., et al. Control of immature Ixodes scapularis (Acari: Ixodidae) on rodent reservoirs of Borrelia burgdorferi in a residential community of southeastern Connecticut. J Med Entomol 41 6 (2004) 1043-1054
2. Luke C.J., Huebner R.C., Kasmiersky V., and Barbour A.G. Oral delivery of purified lipoprotein OspA protects mice from systemic infection with Borrelia burgdorferi. Vaccine 15 6-7 (1997) 739-746
3. Pastoret P.P., Brochier B., Languet B., Thomas I., Paquot A., Bauduin B., et al. First field trial of fox vaccination against rabies using a vaccinia-rabies recombinant virus. Vet Rec 123 19 (1988) 481-483
4. Knobel D.L., du Toit J.T., and Bingham J. Development of a bait and baiting system for delivery of oral rabies vaccine to free-ranging African wild dogs (Lycaon pictus). J Wildl Dis 38 2 (2002) 352-362
5. Estrada R., Vos A., De Leon R., and Mueller T. Field trial with oral vaccination of dogs against rabies in the Philippines. BMC Infect Dis 1 1 (2001) 23
6. Creekmore T.E., Rocke T.E., and Hurley J. A baiting system for delivery of an oral plague vaccine to black-tailed prairie dogs. J Wildl Dis 38 1 (2002) 32-39
7. Brisson D., and Dykhuizen D.E. ospC diversity in Borrelia burgdorferi: different hosts are different niches. Genetics 168 2 (2004) 713-722
8. Derdakova M., Dudioak V., Brei B., Brownstein J.S., Schwartz I., and Fish D. Interaction and transmission of two Borrelia burgdorferi sensu stricto strains in a tick-rodent maintenance system. Appl Environ Microbiol 70 11 (2004) 6783-6788
9. Levine J.F., Wilson M.L., and Spielman A. Mice as reservoirs of the Lyme disease spirochete. Am J Trop Med Hyg 34 2 (1985) 355-360
10. Donahue J.G., Piesman J., and Spielman A. Reservoir competence of white-footed mice for Lyme disease spirochetes. Am J Trop Med Hyg 36 1 (1987) 92-96
11. Ostfeld R.S., Schauber E.M., Canham C.D., Keesing F., Jones C.G., and Wolff J.O. Effects of acorn production and mouse abundance on abundance and Borrelia burgdorferi infection prevalence of nymphal Ixodes scapularis ticks. Vector Borne Zoonotic Dis 1 1 (2001) 55-63
12. Bunikis J., Tsao J., Luke C.J., Luna M.G., Fish D., and Barbour A.G. Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: a longitudinal study in an area where Lyme borreliosis is highly endemic. J Infect Dis 189 8 (2004) 1515-1523
13. Anderson J.F. Ecology of Lyme disease. Conn Med 53 6 (1989) 343-346
14. Fikrig E., Barthold S.W., Kantor F.S., and Flavell R.A. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 250 4980 (1990) 553-556
15. Fikrig E., Barthold S.W., Kantor F.S., and Flavell R.A. Long-term protection of mice from Lyme disease by vaccination with OspA. Infect Immun 60 3 (1992) 773-777
16. de Silva A.M., Telford III S.R., Brunet L.R., Barthold S.W., and Fikrig E. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J Exp Med 183 1 (1996) 271-275
17. Lyme Disease Vaccine Study Group, Steere A.C., Sikand V.K., Meurice F., Parenti D.L., Fikrig E., Schoen R.T., et al. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. N Engl J Med 339 4 (1998) 209-215
18. Mannelli A., Fish D., Daniels T.J., Kharitonenkov I., Tun H., Cozzolino A.C., et al. Detection of Borrelia burgdorferi OspA in Ixodes scapularis larvae by an antigen-capture enzyme-linked immunosorbent assay. New Microbiol 20 4 (1997) 355-359
19. Tsao J., Barbour A.G., Luke C.J., Fikrig E., and Fish D. OspA immunization decreases transmission of Borrelia burgdorferi spirochetes from infected Peromyscus leucopus mice to larval Ixodes scapularis ticks. Vector Borne Zoonotic Dis 1 1 (2001) 65-74
20. Fikrig E., Barthold S.W., Kantor F.S., and Flavell R.A. Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA. J Infect Dis 164 6 (1991) 1224-1227
21. Erdile L.F., and Guy B. OspA lipoprotein of Borrelia burgdorferi is a mucosal immunogen and adjuvant. Vaccine 15 9 (1997) 988-996
22. Dunne M., al-Ramadi B.K., Barthold S.W., Flavell R.A., and Fikrig E. Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis. Infect Immun 63 4 (1995) 1611-1614
23. Tsao J.I., Wootton J.T., Bunikis J., Luna M.G., Fish D., and Barbour A.G. An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proc Natl Acad Sci USA 101 52 (2004) 18159-18164
24. Gu M.B., Choi S.H., and Kim S.W. Some observations in freeze-drying of recombinant bioluminescent Escherichia coli fortoxicity monitoring. J Biotechnol 88 2 (2001) 95-105
25. Johnson B.J., Sviat S.L., Happ C.M., Dunn J.J., Frantz J.C., Mayer L.W., et al. Incomplete protection of hamsters vaccinated with unlipidated OspAfrom Borrelia burgdorferi infection is associated with low levels of antibody to an epitope defined by mAb LA-2. Vaccine 13 12 (1995) 1086-1094
26. Rosner B. Fundamentals of Biostatistics. 3rd ed. (1990), PWS-Kent Publishing Company, Boston, Massachusetts
27. Schubach W.H., Mudri S., Dattwyler R.J., and Luft B.J. Mapping antibody-binding domains of the major outer surface membrane protein (OspA) of Borrelia burgdorferi. Infect Immun 59 6 (1991) 1911-1915
28. Schaible U.E., Kramer M.D., Eichmann K., Modolell M., Museteanu C., and Simon M.M. Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc Natl Acad Sci USA 87 10 (1990) 3768-3772
29. Simon M.M., Schaible U.E., Kramer M.D., Eckerskorn C., Museteanu C., Muller-Hermelink H.K., et al. Recombinant outer surface protein a from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice. J Infect Dis 164 1 (1991) 123-132
30. Wilske B., Luft B., Schubach W.H., Zumstein G., Jauris S., Preac-Mursic V., et al. Molecular analysis of the outer surface protein A (OspA) of Borrelia burgdorferi for conserved and variable antibody binding domains. Med Microbiol Immunol 81 4 (1992) 191-207
31. McGrath B.C., Dunn J.J., Gorgone G., Guttman D., Dykhuizen D., and Luft B.J. Identification of an immunologically important hypervariable domain of major outer surface protein A of Borrelia burgdorferi. Infect Immun 63 4 (1995) 1356-1361
32. Willett T.A., Meyer A.L., Brown E.L., and Huber B.T. An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope. Proc Natl Acad Sci USA 101 5 (2004) 1303-1308
33. Wang I.N., Dykhuizen D.E., Qiu W., Dunn J.J., Bosler E.M., and Luft B.J. Genetic diversity of ospC in a local population of Borrelia burgdorferi sensu stricto. Genetics 151 1 (1999) 15-30
34. Seinost G., Dykhuizen D.E., Dattwyler R.J., Golde W.T., Dunn J.J., Wang I.N., et al. Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans. Infect Immun 67 7 (1999) 3518-3524
35. Qiu W.G., Dykhuizen D.E., Acosta M.S., and Luft B.J. Geographic uniformity of the Lyme disease spirochete (Borrelia burgdorferi) and its shared history with tick vector (Ixodes scapularis) in the Northeastern United States. Genetics 160 3 (2002) 833-849
36. Piesman J., and Happ C.M. Ability of the Lyme disease spirochete Borrelia burgdorferi to infect rodents and three species of human-biting ticks (blacklegged tick, American dog tick, lone star tick) (AcarMxodidae). J Med Entomol 34 4 (1997) 451-456
37. Dolan M.C., Piesman J., Mbow M.L., Maupin G.O., Peter O., Brossard M., et al. Vector competence of Ixodes scapularis and Ixodes ricinus (Acari: Ixodidae) for three genospecies of Borrelia burgdorferi. J Med Entomol 35 4 (1998) 465-470
38. Piesman J., Clark K.L., Dolan M.C., Happ C.M., and Burkot T.R. Geographic survey of vector ticks (Ixodes scapularis and Ixodes pacificus) for infection with the Lyme disease spirochete, Borrelia burgdorferi. J Vector Ecol 24 1 (1999) 91-98
39. LoGiudice K., Ostfeld R.S., Schmidt K.A., and Keesing F. The ecology of infectious disease: effects of host diversity and community composition on Lyme disease risk. Proc Natl Acad Sci USA 100 2 (2003) 567-571
40. Wormser G.P., Liveris D., Nowakowski J., Nadelman R.B., Cavaliere L.F., McKenna D., et al. Association of specific subtypes of Borrelia burgdorferi with hematogenous dissemination in early Lyme disease. J Infect Dis 180 3 (1999) 720-725
41. Wormser G.P., Nadelman R.B., Nowakowski J., and Schwartz I. Asymptomatic Borrelia burgdorferi infection. Med Hypotheses 57 4 (2001) 435-438
42. Wang G., Ojaimi C., Iyer R., Saksenberg V., McClain S.A., Wormser G.P., et al. Impact of genotypic variation of Borrelia burgdorferi sensu stricto on kinetics of dissemination and severity of disease in C3H/HeJ mice. Infect Immun 69 7 (2001) 4303-4312
43. Wang G., Ojaimi C., Wu H., Saksenberg V., Iyer R., Liveris D., et al. Disease severity in a murine model of Lyme borreliosis is associated with the genotype of the infecting Borrelia burgdorferi sensu stricto strain. J Infect Dis 186 6 (2002) 782-791
44. Mather T.N., Telford III S.R., and Adler G.H. Absence of transplacental transmission of Lyme disease spirochetes from reservoir mice (Peromyscus leucopus) to their offspring. J Infect Dis 164 3 (1991) 564-567
45. Magnarelli L.A., Anderson J.F., and Chappell W.A. Antibodies to spirochetes in white-tailed deer and prevalence of infected ticks from foci of Lyme disease in Connecticut. J Wildl Dis 20 1 (1984) 21-26
46. Magnarelli L.A., Anderson J.F., Anderson C.S., Fish D., Johnson R.C., and Chappell W.A. Spirochetes in ticks and antibodies to Borrelia burgdorferi in white-tailed deer from Connecticut, New YorkState, and North Carolina. J Wildl Dis 22 2 (1986) 178-188
47. Stafford III K.C. Reduced abundance of Ixodes scapularis (Acari: Ixodidae) with exclusion of deer by electric fencing. J Med Entomol 30 6 (1993) 986-996
48. Stafford III K.C., Cartter M.L., Magnarelli L.A., Ertel S.H., and Mshar P.A. Temporal correlations between tick abundance and prevalence of ticks infected with Borrelia burgdorferi and increasing incidence of Lyme disease. J Clin Microbiol 36 5 (1998) 1240-1244
49. Kawano Y., Noma T., and Yata J. Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2. J Immunol 153 11 (1994) 4948-4958
50. Remington M.C., Munson E.L., Callister S.M., Molitor M.L., Christopherson J.A., DeCoster D.J., et al. Interleukin-6 enhances production of anti-OspC immunoglobulin G2b borreliacidal antibody. Infect Immun 69 7 (2001) 4268-4275
51. Munson E.L., Du Chateau B.K., Jobe D.A., Lovrich S.D., Callister S.M., and Schell R.F. Production of borreliacidal antibody to outer surface protein A in vitro and modulation by interleukin-4. Infect Immun 68 10 (2000) 5496-5501
52. Rathinavelu S., Broadwater A., and de Silva A.M. Does host complement kill Borrelia burgdorferi within ticks?. Infect Immun 71 2 (2003) 822-829
53. Keane-Myers A., Maliszewski C.R., Finkelman F.D., and Nickell S.P. Recombinant IL-4 treatment augments resistance to Borrelia burgdorferi infections in both normal susceptible and antibody-deficient susceptible mice. J Immunol 156 7 (1996) 2488-2494