Composition of Hypericum perforatum L. and its medical importance;Kantaronun (Hypericum perforatum L.) bileşimi ve tibbi önemi

UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi

Volumn 15, Issue 4, 2005, Pages 212-218

  Hişil, Yaşar ^a   Şahin, Fahri ^a   Omay, Serdar Bedii ^b  

^a EGE UNIVERSITY   (Turkey)

^b KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Cancer treatment; Hypericin; St. John's wort

Indexed keywords

AMENTOFLAVONE; ANTIDEPRESSANT AGENT; ANTINEOPLASTIC AGENT; ASCORBIC ACID; CAFFEIC ACID; CHLOROGENIC ACID; FERULIC ACID; HYPERFORIN; HYPERICIN; HYPERICUM PERFORATUM EXTRACT; HYPERIN; ISOQUERCITRIN; PSEUDOHYPERICIN; QUERCETIN; QUERCITRIN; RETINOL; RUTOSIDE; SITOSTEROL;

CHROMATOGRAPHY; DEPRESSION; DRUG EFFICACY; EUROPE; HUMAN; HYPERICUM PERFORATUM; REVIEW; TRADITIONAL MEDICINE; UNITED STATES;

EID: 33646470291     PISSN: 1306133X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (30)

1. Merck Index, 2003. 13th Edition. Merck & Co., Inc. Whitehouse Station, NJ.
2. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D. St John's wort for depression-an overview and meta-analysis of randomised clinical trials. BMJ 3;313:253-8, 1996.
3. Volz HP. Controlled clinical trials of hypericum extracts in depressed patients-an overview. Pharmacopsychiatry. 30 Suppl 2:72-6, 1997.
4. Gaster B, Holroyd J. St John's wort for depression: a systematic review. Arch Intern Med. 24;160(2):152-6, 2000.
5. Bombardelli E, Morazzoni P. Hypericum perforatum. Fitoterapia, 66,1: 43-68, 1995.
6. Butterweck V, Jurgenliemk G, Nahrstedt A, Winterhoff H. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta Med 66(1):3-6, 2000.
7. L184 of July 15,1988, in Official Journal of the European Communities, p.61 (EEC Council Directive 88/388 of June 22, 1988.
8. Bilia AR, Gallori S, Vincieri FF. St. John's Worth and depression-efficiency, safety and tolerability. Life Sciences 70: 3077-3096, 2002.
9. Brolis M, Gabetta B, Fuzzari N, Pace R, Panzeri F, Peterlongo F. Identification by high-performance liquid chromatography-diode array detection-mass spectrometry and quantification by high-performance liquid chromatography-UV absorbance detection of active constituents of Hypericum perforatum. J Chromatogr A 825:9-16,1998. (with permission from Elsevier).
10. Harrer G, Schulz V. Clinical investigation of the antidepressant effectiveness of hypericum. J Geriatr Psychiatry Neurol 1:S6-8, 1994.
11. Vorbach EU, Hubner WD, Arnoldt KH. Effectiveness and tolerance of the hypericum extract LI 160 in comparison with imipramine: randomized double-blind study with 135 outpatients. J Geriatr Psychiatry Neurol 1: S19-23, 1994.
12. Hudson JB, Lopez-Bazzocchi I, Towers GH. Antiviral activities of hypericin. Antiviral Res 15(2):101-12, 1991.
13. Tang J, Colacino JM, Larsen SH, Spitzer W. Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses. Antiviral Res 13(6):313-25, 1990.
14. Stojanovic G, Palic R, Tarr CH, Reddy CM, Marinkovic, O. n-alkannes and fatty acids of Hypericum perforatum, Hypericum maculatum and Hypericum olympicum. Biochemical Systematics and Ecology 31, 223-226, 2003.
15. Cui Y, Gurley B, Ang CYW, Leakey J. Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection. J Chromatogr B 780:129-135, 2002.
16. Vandenbogaerde AL, Kamuhabwa A, Delay E, Himpens BE, Merlevede WJ, De Witte PA. Photocytotoxic effect of pseudohypericin versus hypericin. J Photochem Photobiol B Biol 45: 87-94, 1998.
17. Liebes L, Mazur Y, Freeman D, Lavie D, Lavie G, Kudler N, et al. A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography. Anal Biochem 15;195(1):77-85, 1991.
18. Chi JD, Franklin M. Determination of hypericin in plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 5;724(1):195-8, 1999.
19. Draves AH, Walker SE. Determination of hypericin and pseudohypericin in pharmaceutical preparations by liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl 10;749(1):57-66, 2000.
20. Zotou A, Loukou Z. Determination of Hypericin and Pseudohypericin in Extracts from Hypericum perforatum L. and Pharmaceutical Preparations by Liquid Chromatography - Fluorescence Detection. Chromatographia 54:218-224, 2001.
21. Li W, Fitzloff JF. High performance liquid Chromatographic analysis of St. John's Wort with photodiode array detection. J Chromatogr B 765:99-105, 2001. (with permission from Elsevier).
22. Schwob I, Bessiere JM, Viano J. Composition of the essential oils of Hypericum perforatum L. from southeastern France. C R Biologies 325, 781-785, 2002.
23. Agostinis P, Vantieghem A, Merlevede W, de Witte PA. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol 34(3):221-41, 2002.
24. Hopfner M, Maaser K, Theiss A, Lenz M, Sutter AP, Kashtan H, et al. Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells. Int J Colorectal Dis 18(3):239-47, 2003.
25. Bruggisser R, von Daeniken K, Jundt G, Schaffner W, Tullberg-Reinert H. Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay. Planta Med 68(5):445-8, 2002.
26. Hostanska K, Reichling J, Bommer S, Weber M, Saller R. Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. Eur J Pharm Biopharm 56(1):121-32, 2003.
27. Tedeschi E, Menegazzi M, Margotto D, Suzuki H, Forstermann U, Kleinert H. Anti-inflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1 alpha (STAT-1alpha) activation. J Pharmacol Exp Ther 307(1):254-61, 2003.
28. Shiono Y, Shiono N, Seo S, Oka S, Yamazaki Y. Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Z Naturforsch [C]. 57(9-10):923-9, 2002.
29. Kim JI, Park JH, Park HJ, Choi SK, Lee KT. Induction of differentiation of the human histocytic lymphoma cell line U-937 by hypericin. Arch Pharm Res 21(1):41-5, 1998.
30. Hwang MS, Yum YN, Joo JH, Kim S, Lee KK, Gee SW, et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res 21:2649-55, 2001.