Validation of hypothesis of pressure reversal mechanisms: "Anesthetic binds to site, and squeezed out by pressure"

International Congress Series

Volumn 1283, Issue , 2005, Pages 318-319

  Isogai, Hideto ^b   Seto, Tomoyoshi ^a   Nosaka, Shuichi ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b RITSUMEIKAN UNIVERSITY   (Japan)

Author keywords

Docking simulation; Pressure reversal; Protein; Xenon

Indexed keywords

EID: 33646458543     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.ics.2005.06.073     Document Type: Article

References (3)

1. Moss G.W., Lieb W.R., and Franks N.P. Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal. Biophys. J. 60 6 (1991) 1309-1314
2. Prange T., et al. Exploring hydrophobic sites in proteins with xenon or krypton. Proteins 30 1 (1998) 61-73
3. Refaee M., et al. Pressure-dependent changes in the solution structure of hen egg-white lysozyme. J. Mol. Biol. 327 4 (2003) 857-865