A prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee

Journal of Rheumatology

Volumn 33, Issue 5, 2006, Pages 951-956

  Petrella, Robert J ^a,b   Petrella, Michael ^a  

^a WESTERN UNIVERSITY   (Canada)

^b Heart Hlth and Exercise Lab   (Canada)

Author keywords

Dosing frequency; Hyaluronic acid; Knee; Osteoarthritis

Indexed keywords

ACETYLSALICYLIC ACID; HYALURONIC ACID; PARACETAMOL; PLACEBO; SODIUM; SODIUM CHLORIDE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; HUMAN; JOINT STIFFNESS; JOINT SWELLING; KNEE FUNCTION; KNEE OSTEOARTHRITIS; KNEE PAIN; KNEE RADIOGRAPHY; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; PATIENT SATISFACTION; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SHORT FORM 36; VISUAL ANALOG SCALE; WALKING; WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX;

AGED; ARTHRALGIA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; KNEE JOINT; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PATIENT SATISFACTION; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME; WALKING;

EID: 33646457359     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Dahlberg L, Lohmander LS, Ryd L. Intraarticular injections of hyaluronan in patients with cartilage abnormalities and knee pain. Arthritis Rheum 1994;37:521-8.
2. Dougados M, Nguyen M, Listrat V, Amor B. High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: a 1-year placebo-controlled trial. Osteoarthritis Cartilage 1993;1:97-103.
3. Petrella RJ, DiSilvestro MD, Hildebrand C. Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee. Arch Intern Med 2002;162:292-8.
4. Karlsson J, Sjogren LS, Lohmander LS. Comparison of two hyaluronan drugs and placebo in patients with knee osteoarthritis: a controlled, randomized, double-blind, parallel-design multi-center study. Rheumatology Oxford 2002;41:1240-8.
5. Petrella RJ. Hyaluronic acid for the treatment of knee osteoarthritis: Long-term outcomes from a naturalistic primary care experience. Am J Phys Med 2005;84:278-83.
6. Lussier A, Cividino AA, McFarlane CA, Olszinski WP, Potashner WJ, DeMedicis R. Viscosupplementation with hyalgan for the treatment of osteoarthritis: findings from clinical practice in Canada. J Rheumatol 1996;23:1579-85.
7. Lo GH, LaValley M, McAlindon T, Felson DT. Intraarticular hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. JAMA 2003;290:3115-21.
8. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 2005;2:CD005321.
9. Arrich J, Prirbauer F, Mad P, Schmid D, Klaushofer K, Mullner M. Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta analysis. CMAJ 2005;172:1039-43.
10. Balasz EA, Denlinger SL. Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol 1993;20 Suppl 39:3-9.
11. Bellamy N. Osteoarthritis clinical trials: Candidate variables and clinimetric properties. J Rheumatol 1997;24:768-78.
12. Begg C, Cho M, Eastwood S, et al. Improving the quality of reporting clinical trials: The CONSORT statement. JAMA 1996;276:637-9.
13. Bellamy N, Buchanan W, Goldsmith C, et al. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988;15:1833-40.
14. Ware JE, Snow KK, Kosinski M, Gandek B. SF-36. Health survey manual and interpretation guide. Boston: New England Medical Centre, The Health Institute; 1993.
15. Altman RD, Fries JF, Bloch DA, et al. Radiographic assessment of progression in osteoarthritis. Arthritis Rheum 1987;30:1214-25.
16. Adams ME, Atkinson MH, Lussier AJ, et al. The role of viscosupplementation with hylan GF-20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multi-centre trial comparing hylan GF-20 alone, hylan GF-20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthritis Cartilage 1995;3:213-26.
17. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000;43:1905-15.