-
1
-
-
0032127244
-
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
-
Miwa M, Ura M, Nishida M et al.: Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur. J. Cancer 34(8), 1274-1281 (1998)
-
(1998)
Eur. J. Cancer
, vol.34
, Issue.8
, pp. 1274-1281
-
-
Miwa, M.1
Ura, M.2
Nishida, M.3
-
2
-
-
0028809240
-
Thymidine phosphorylase is angiogenic and promotes tumor growth
-
Moghaddam A, Zhang HT, Fan TP et al.: Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc. Natl Acad. Sci. USA 92(4), 998-1002 (1995)
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, Issue.4
, pp. 998-1002
-
-
Moghaddam, A.1
Zhang, H.T.2
Fan, T.P.3
-
3
-
-
0034016415
-
Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients
-
Schuller J, Cassidy J, Dumont E et al.: Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother. Pharmacol. 45(4), 291-297 (2000)
-
(2000)
Cancer Chemother. Pharmacol.
, vol.45
, Issue.4
, pp. 291-297
-
-
Schuller, J.1
Cassidy, J.2
Dumont, E.3
-
4
-
-
0035076059
-
Weidekamm: Clinical pharmacokinetics of capecitabine
-
Reigner B, Blesch K, Weidekamm: Clinical pharmacokinetics of capecitabine. E. Clin. Pharmacokinet. 40(2), 85-104 (2001)
-
(2001)
E. Clin. Pharmacokinet.
, vol.40
, Issue.2
, pp. 85-104
-
-
Reigner, B.1
Blesch, K.2
-
5
-
-
0032874167
-
A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of 14C-labelled drug
-
Judson IR, Beale PJ, Trigo JM et al.: A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of 14C-labelled drug. Invest. New Drugs 17(1), 49-56 (1999)
-
(1999)
Invest. New Drugs
, vol.17
, Issue.1
, pp. 49-56
-
-
Judson, I.R.1
Beale, P.J.2
Trigo, J.M.3
-
6
-
-
0031671094
-
Phase i and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer
-
Mackean M, Planting A, Twelves C et al.: Phase I and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer. J. Clin. Oncol. 16(9), 2977-2985 (1998)
-
(1998)
J. Clin. Oncol.
, vol.16
, Issue.9
, pp. 2977-2985
-
-
Mackean, M.1
Planting, A.2
Twelves, C.3
-
7
-
-
0031859855
-
Preliminary studies of a novel oral fluoropyrimidine carbamate: Capecitabine
-
Budman DR, Meropol NJ, Reigner B et al.: Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine. J. Clin. Oncol. 16(5), 1795-1802 (1998)
-
(1998)
J. Clin. Oncol.
, vol.16
, Issue.5
, pp. 1795-1802
-
-
Budman, D.R.1
Meropol, N.J.2
Reigner, B.3
-
8
-
-
0031724433
-
A Phase i study of capecitabine in combination with oral leucovorin in patients with intractable solid tumors
-
Cassidy J, Dirix L, Bissett D et al.: A Phase I study of capecitabine in combination with oral leucovorin in patients with intractable solid tumors. Clin. Cancer Res. 4(11), 2755-2761 (1998)
-
(1998)
Clin. Cancer Res
, vol.4
, Issue.11
, pp. 2755-2761
-
-
Cassidy, J.1
Dirix, L.2
Bissett, D.3
-
9
-
-
0034016343
-
Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: Results of a randomized Phase II study
-
Van Cutsem E, Findlay M, Osterwalder B et al.: Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized Phase II study. J. Clin. Oncol. 18(6), 1337-1345 (2000)
-
(2000)
J. Clin. Oncol.
, vol.18
, Issue.6
, pp. 1337-1345
-
-
Van Cutsem, E.1
Findlay, M.2
Osterwalder, B.3
-
10
-
-
0035871538
-
Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized Phase III study
-
Hoff PM, Ansari R, Batist G et al.: Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized Phase III study. J. Clin. Oncol. 19(8), 2282-2292 (2001)
-
(2001)
J. Clin. Oncol.
, vol.19
, Issue.8
, pp. 2282-2292
-
-
Hoff, P.M.1
Ansari, R.2
Batist, G.3
-
11
-
-
0035503151
-
Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large Phase III study
-
Van Cutsem E, Twelves C, Cassidy J et al.: Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large Phase III study. J. Clin. Oncol. 19(21), 4097-4106 (2001)
-
(2001)
J. Clin. Oncol.
, vol.19
, Issue.21
, pp. 4097-4106
-
-
Van Cutsem, E.1
Twelves, C.2
Cassidy, J.3
-
12
-
-
11144354462
-
Oral capecitabine vs intravenous 5- fluorouracil and leucovorin: Integrated efficacy data and novel analyses from two large, randomised, phase III trials
-
Van Cutsem E, Hoff PM, Harper P et al.: Oral capecitabine vs intravenous 5- fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials. Br. J. Cancer 90(6), 1190-1197 (2004)
-
(2004)
Br. J. Cancer
, vol.90
, Issue.6
, pp. 1190-1197
-
-
Van Cutsem, E.1
Hoff, P.M.2
Harper, P.3
-
13
-
-
0036235128
-
First-line oral capecitabine therapy in metastatic colorectal cancer: A favourable safety profile compared with intravenous 5 florouracil/leucovorin
-
Cassidy J, Twelves C, Van Cutsem E et al.: First-line oral capecitabine therapy in metastatic colorectal cancer: a favourable safety profile compared with intravenous 5 florouracil/leucovorin. Ann. Oncol. 13(4), 566-575 (2002)
-
(2002)
Ann. Oncol.
, vol.13
, Issue.4
, pp. 566-575
-
-
Cassidy, J.1
Twelves, C.2
Van Cutsem, E.3
-
15
-
-
9144238357
-
X-ACT Study Group. Oral capecitabine as an alternative to i.v. 5- fluorouracil-based adjuvant therapy for colon cancer: Safety results of a randomized, Phase III trial
-
Scheithauer W, McKendrick J, Begbie S et al.: X-ACT Study Group. Oral capecitabine as an alternative to i.v. 5- fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, Phase III trial. Ann Oncol. 12, 1735-1743 (2003)
-
(2003)
Ann Oncol.
, vol.12
, pp. 1735-1743
-
-
Scheithauer, W.1
McKendrick, J.2
Begbie, S.3
-
16
-
-
1842569206
-
A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
-
Goldberg RM, Sargent DJ, Morton RF et al.: A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol. 22(1), 23-30 (2004)
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.1
, pp. 23-30
-
-
Goldberg, R.M.1
Sargent, D.J.2
Morton, R.F.3
-
17
-
-
2942638081
-
XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer
-
Cassidy J, Tabernero J, Twelves C et al.: XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. J. Clin. Oncol. 22(11), 2084-2091 (2004)
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.11
, pp. 2084-2091
-
-
Cassidy, J.1
Tabernero, J.2
Twelves, C.3
-
18
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
de Gramont, Figer A, Seymour M et al.: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J. Clin. Oncol. 18(16), 2938-2947 (2000)
-
(2000)
J. Clin. Oncol.
, vol.18
, Issue.16
, pp. 2938-2947
-
-
De Gramont Figer, A.1
Seymour, M.2
-
19
-
-
2542615200
-
Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
-
Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators
-
Andre T, Boni C, Mounedji-Boudiaf L, Navarro M: Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N. Engl. J. Med. 350(23), 2343-2351 (2004)
-
(2004)
N. Engl. J. Med.
, vol.350
, Issue.23
, pp. 2343-2351
-
-
Andre, T.1
Boni, C.2
Mounedji-Boudiaf, L.3
Navarro, M.4
-
20
-
-
4444242977
-
Capecitabine (X) plus irinotecan (XELIRI) as first-line treatment for metastatic colorectal cancer (MCRC): Final safety findings from a Phase II trial
-
[Abstract 3602]
-
Patt YZ, Liebmann J, Diamandidis D et al.: Capecitabine (X) plus irinotecan (XELIRI) as first-line treatment for metastatic colorectal cancer (MCRC): final safety findings from a Phase II trial. Proc. Am. Soc. Clin. Oncol. [Abstract 3602] (2004)
-
(2004)
Proc. Am. Soc. Clin. Oncol.
-
-
Patt, Y.Z.1
Liebmann, J.2
Diamandidis, D.3
-
21
-
-
0012465969
-
A phase I/II study of CPT-11 in combination with capecitabine as first line chemotherapy for metastatic colorectal cancer (MCRC)
-
Kerr DJ, Ten Bokkel Huinink W,Ferry DR, et al.: A phase I/II study of CPT-11 in combination with capecitabine as first line chemotherapy for metastatic colorectal cancer (MCRC) ASCO (2002)
-
(2002)
ASCO
-
-
Kerr, D.J.1
Ten Bokkel, H.W.2
Ferry, D.R.3
-
22
-
-
84875933605
-
Dose escalation and pharmacokinetic study of capecitabine (Xeloda) and irinotecan (CPT- 11) in gastro-intestinal tumors: Preliminary results
-
Delord JP, Pierga JY, Dieras V et al.: Dose escalation and pharmacokinetic study of capecitabine (Xeloda) and irinotecan (CPT- 11) in gastro-intestinal tumors: preliminary results. ASCO (2002)
-
(2002)
ASCO
-
-
Delord, J.P.1
Pierga, J.Y.2
Dieras, V.3
-
23
-
-
2942648695
-
Four decades of continuing innovation with fluorouracil: Current and future approaches to fluorouracil chemoradiation therapy
-
Rich TA, Shepard RC, Mosley ST: Four decades of continuing innovation with fluorouracil: current and future approaches to fluorouracil chemoradiation therapy. J. Clin. Oncol. 22(11), 2214-2232 (2004)
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.11
, pp. 2214-2232
-
-
Rich, T.A.1
Shepard, R.C.2
Mosley, S.T.3
-
24
-
-
0036787579
-
Phase i trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer
-
Dunst J, Reese T, Sutter T et al.: Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer. J. Clin. Oncol. 20(19), 3983-3991 (2002)
-
(2002)
J. Clin. Oncol.
, vol.20
, Issue.19
, pp. 3983-3991
-
-
Dunst, J.1
Reese, T.2
Sutter, T.3
-
25
-
-
5044220099
-
A phase i trial of preoperative radiotherapy and capecitabine for locally advanced, potentially resectable rectal cancer
-
Ngan SY, Michael M, Mackay J et al.: A phase I trial of preoperative radiotherapy and capecitabine for locally advanced, potentially resectable rectal cancer. Br. J. Cancer 91(6), 1019-1024 (2004)
-
(2004)
Br. J. Cancer
, vol.91
, Issue.6
, pp. 1019-1024
-
-
Ngan, S.Y.1
Michael, M.2
Mackay, J.3
-
26
-
-
0036176033
-
Xeloda Colorectal Cancer Group: Capecitabine as first-line treatment in colorectal cancer. Pooled data from two large, phase III trials
-
Twelves C, Xeloda Colorectal Cancer Group: Capecitabine as first-line treatment in colorectal cancer. Pooled data from two large, phase III trials. Eur. J. Cancer 38 (2), 15-20 (2002)
-
(2002)
Eur. J. Cancer
, vol.38
, Issue.2
, pp. 15-20
-
-
Twelves, C.1
|