Genetic thrombophilia in patients with VTE in eastern mediterranean located tertiary care center; is it time to change the algorithm for thrombophilia work up decision making?

Journal of Thrombosis and Thrombolysis

Volumn 21, Issue 3, 2006, Pages 267-270

  Isma'eel, H ^a   El Accaoui, R ^a   Shamseddeen, W ^a   Taher, A ^a   Alam, S ^a   Mahfouz, R ^a   Arnaout, M S ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Doubly heterozygous; Lebanon; Thrombophilia

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; HEPARIN; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); ORAL CONTRACEPTIVE AGENT; PROTHROMBIN;

ADULT; AGED; ALGORITHM; CLINICAL ARTICLE; CONTROLLED STUDY; EMBOLISM PREVENTION; FEMALE; GENETIC DISORDER; HEMATOLOGIC MALIGNANCY; HETEROZYGOSITY; HUMAN; LEBANON; LUNG EMBOLISM; MALE; MEDICAL DECISION MAKING; MEDICAL RECORD REVIEW; MUTATION RATE; MUTATIONAL ANALYSIS; ORAL CONTRACEPTION; POSTOPERATIVE COMPLICATION; PREDICTION; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; RISK ASSESSMENT; RISK FACTOR; TERTIARY HEALTH CARE; THROMBOSIS PREVENTION; VENOUS THROMBOEMBOLISM;

ADULT; AGED; ALGORITHMS; DECISION MAKING; FACTOR V; FEMALE; HUMANS; LEBANON; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; RETROSPECTIVE STUDIES; THROMBOEMBOLISM; THROMBOPHILIA; VENOUS THROMBOSIS;

EID: 33646435118     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11239-006-5537-1     Document Type: Review

References (17)

1. Wood KE. Major pulmonary embolism: Review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism. Chest 2002;121(3):877-905.
2. Lopez JA, Kearon C, Lee AY. Deep venous thrombosis. Hematology (Am Soc Hematol Educ Program) 2004;439-456.
3. Caprini JA, Goldshteyn S, Glase CJ, Hathaway K. Thrombophilia testing in patients with venous thrombosis. Eur J Vasc Endovasc Surg 2005.
4. McColl MD, Ramsay JE, Trait RC, et al. Risk factors for pregnancy associated venous thromboembolism. Thromb Haemost 1997;78:1183.
5. Friederich PW, Sanson B-J, Simioni P, et al. Frequency of pregnancy related venous thromboembolism in anticoagulant factor-deficient women: Implications for prophylaxis. Ann Intern Med 1996;125:955.
6. Heijboer H, Brandjes DP, Buller HR, et al. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep vein thrombosis. N Engl J Med 1990;323:1512.
7. Murin S, Marelich GP, Arroliga AC, Matthay RA. Hereditary thrombophilia and venous thromboembolism. Am J Respir Crit Care Med 1998;158:1369.
8. Mansilha A, Araujo F, Severo M, Sampaio SM, Toledo T, Albuquerque R. Genetic Polymorphisms and Risk of Recurrent Deep Venous Thrombosis in Young People: Prospective Cohort Study. Eur J Vasc Endovasc Surg 2005.
9. Almawi WY, Finan RR, Tamim H, Daccache JL, Irani-Hakime N. Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene among the Lebanese population. Am J Hematol 2004;76(1):85-87.
10. Zalloua PA, Shbaklo H, Mourad YA, Koussa S, Taher A. Incidence of thromboembolic events in Lebanese thalassemia intermedia patients. Thromb Haemost 2003;89(4):767-768.
11. Taher A, Khalil I, Shamseddine A, El-Ahdab F, Bazarbachi A. High prevalence of Factor V Leiden mutation among healthy individuals and patients with deep venous thrombosis in Lebanon: Is the eastern Mediterranean region the area of origin of this mutation? Thromb Haemost 2001;86(2):723-724.
12. Isma'eel H, Taher A, Alam S, Arnaout MS. Massive Pulmonary Embolism in a Lebanese patient doubly heterozygous for MTHFR and Factor V Leiden presenting with Syncope and treated with Tenecteplase. Journal of Thrombosis and Thrombolysis 2005 (In Press).
13. Caprini JA. Thrombosis risk assessment as a guide to quality patient care. Dis Mon 2005;51(2-3):70-78.
14. Nicolaides AN. Thrombophilia and venous thromboembolism. International Consensus Statement. Guidelines According to Scientific Evidence. Int Angiol 2005;24(1):1-26.
15. Buller HR, Agnelli G, Hull RD, Hyers TM, Prins MH, Raskob GE. Antithrombotic therapy for venous thromboembolic disease: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004;126(3 Suppl):401S-428S. Review. Erratum in: Chest 2005;127(1):416.
16. Goldhaber SZ, Tapson VF; DVT FREE Steering Committee. A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis. Am J Cardiol 2004;93(2):259-62.
17. Gallus AS. Travel, venous thromboembolism, and thrombophilia. Semin Thromb Hemost 2005;31(1):90-96.