[35S]GTPγS binding stimulated by endomorphin-2 and morphiceptin analogs

Biochemical and Biophysical Research Communications

Volumn 345, Issue 1, 2006, Pages 162-168

  Fichna, Jakub ^a   do Rego, Jean Claude ^b   Kosson, Piotr ^c   Schiller, Peter W ^d   Costentin, Jean ^b   Janecka, Anna ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b IFRMP 23   (France)

^c MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^d CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Opioid receptor ligand; Agonist; Antagonist; Functional assay; G protein coupled receptor; Rat thalamus

Indexed keywords

ENDOMORPHIN 2; ENDORPHIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ISOPROTEIN; MORPHICEPTIN; OLIGOPEPTIDE; SULFUR;

ANIMAL; ARTICLE; BINDING SITE; BRAIN; BRAIN LEVEL; CELL CULTURE; CHEMISTRY; MALE; METABOLISM; PROTEIN BINDING; RADIOASSAY; RAT; WISTAR RAT;

ANIMALS; BINDING SITES; BRAIN; BRAIN CHEMISTRY; CELLS, CULTURED; ENDORPHINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN ISOFORMS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; SULFUR RADIOISOTOPES;

EID: 33646429825     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.04.079     Document Type: Article

References (24)

1. Gilman A.G. G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56 (1987) 615-649
2. Carter B.D., and Medzihradsky F. Go mediates the coupling of the μ opioid receptor to adenylyl cyclase in cloned neural cells and brain. Proc. Natl. Acad. Sci. USA 90 (1993) 4062-4066
3. Childers S.R. Opioid receptor-coupled second messenger systems. Life Sci. 48 (1991) 1991-2003
4. North R.A., Williams J.T., Surprenant A., and Christie M.J. μ and δ receptors belong to a family of receptors that are coupled to potassium channels. Proc. Natl. Acad. Sci. USA 84 (1987) 5487-5491
5. Hescheler J., Rosenthal W., Trautwein W., and Schultz G. The GTP-binding protein, Go, regulates neuronal calcium channels. Nature 325 (1987) 445-447
6. Akil H., Watson S.J., Young E., Lewis M.E., Khachaturian H., and Walker J.M. Endogenous opioids: biology and function. Annu. Rev. Neurosci. 7 (1984) 223-255
7. Hughes J., Smith T.W., Kosterlitz H.W., Fothergill L.A., Morgan B.A., and Morris H.R. Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258 (1975) 577-579
8. Goldstein A., Tachibana S., Lowney L.I., Hunkapiller M., and Hood L. Dynorphin (10-13), an extraordinarily potent opioid peptide. Proc. Natl. Acad. Sci. USA 76 (1979) 6666-6670
9. Zadina J.E., Hackler L., Ge L.J., and Kastin A.J. A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 (1997) 499-502
10. Chang K.J., Su Y.F., Brent D.A., and Chang J.K. Isolation of a specific mu-opiate receptor peptide, morphiceptin, from an enzymatic digest of milk proteins. J. Biol. Chem. 260 (1985) 9706-9712
11. Janecka A., Fichna J., Wiercioch R., and Mirowski M. Synthesis of novel morphiceptin analogues modified in position 3 and their binding to mu-opioid receptors in experimental mammary adenocarcinoma. Bioorg. Med. Chem. 11 (2003) 3855-3860
12. Fichna J., do-Rego J.-C., Costentin J., Chung N.N., Schiller P.W., Kosson P., and Janecka A. Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogs. Biochem. Biophys. Res. Commun. 320 (2004) 531-536
13. 35S]thio]-triphosphate binding. Proc. Natl. Acad. Sci. USA 92 (1995) 7242-7246
14. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
15. Kosterlitz H.W., and Watt A.J. Kinetic parameters of narcotic agonists and antagonists, with particular reference to N-allylnoroxymorphone (naloxone). Brit. J. Pharmacol. 33 (1968) 266-276
16. 35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol. Pharmacol. 47 (1995) 848-854
17. 35S]-triphosphate binding. Mol. Pharmacol. 44 (1993) 115-123
18. Yamazaki T., Ro S., Goodman M., Chung N.N., and Schiller P.W. A topochemical approach to explain morphiceptin bioactivity. J. Med. Chem. 36 (1993) 708-712
19. Fichna J., do-Rego J.-C., Costentin J., and Janecka A. Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position. Biochem. Pharmacol. 69 (2005) 179-185
20. Kruszynski R., Fichna J., do-Rego J.-C., Chung N.N., Schiller P.W., Kosson P., Costentin J., and Janecka A. Novel endomorphin-2 analogs with μ-opioid receptor antagonist activity. J. Pept. Res. 66 (2005) 125-131
21. Kosterlitz H.W., and Paterson S.J. Types of opioid receptors: relation to nociception. Br. J. Pharmacol. 73 (1981) 299P
22. 35S]GTPγS binding in rat brain: evidence for partial agonist activity at mu opioid receptors. J. Neurochem. 70 (1998) 1567-1576
23. Schiller P.W., Nguyen T.M., Chung N.N., and Lemieux C. Dermorphin analogues carrying an increased positive net charge in their "message domain" display extremely high μ opioid receptor selectivity. J. Med. Chem. 32 (1989) 698-703
24. Okada Y., Tsuda Y., Fujita Y., Yokoi T., Sasaki Y., Ambo A., Konishi R., Nagata M., Salvadori S., Jinsmaa Y., Bryant S.D., and Lazarus L.H. Unique high-affinity synthetic μ-opioid receptor agonists with central-and systemic-mediated analgesia. J. Med. Chem. 46 (2003) 3201-3209