A four-dimensional computer simulation model of the in vivo response to radiotherapy of glioblastoma multiforme: Studies on the effect of clonogenic cell density

British Journal of Radiology

Volumn 79, Issue 941, 2006, Pages 389-400

  Stamatakos, G S ^a   Antipas, V P ^a   Uzunoglu, N K ^a   Dale, R G ^b  

^a NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^b CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ALGORITHM; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE; CELL DENSITY; CELL POPULATION; CELL PROLIFERATION; CLONOGENESIS; COMPUTER MODEL; COMPUTER SIMULATION; GENE MUTATION; GLIOBLASTOMA; HUMAN; IMAGE ANALYSIS; IN VIVO STUDY; OXYGENATION; PREDICTION; QUANTITATIVE ANALYSIS; RADIOSENSITIVITY; TREATMENT PLANNING; TUMOR VASCULARIZATION; VALIDATION PROCESS; WILD TYPE;

ALGORITHMS; BRAIN; BRAIN NEOPLASMS; CELL COUNT; CELL CYCLE; CELL DEATH; CELL HYPOXIA; CELL PROLIFERATION; CLONE CELLS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; GLIOBLASTOMA; HUMANS; TREATMENT OUTCOME;

EID: 33646402335     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr/30604050     Document Type: Article

References (63)

1. Kansal AR, Torquato S, Harsh IV GR, Chiocca EA, Deisboeck TS. Simulated brain tumour growth dynamics using a three-dimensional cellular automaton. J Theor Biol 2000;203:367-82.
2. Kansal AR, Torquato S, Harsh IV GR, Chiocca EA, Deisboeck TS. Cellular automaton of idealized brain tumour growth dynamics. BioSystems 2000;55:119-27.
3. Kraus M, Wolf B. Emergence of self-organization in tumour cells: relevance for diagnosis and therapy. Tumour Biol 1993;14:338-53.
4. Duechting W, Ulmer W, Lehrig R, Ginsberg T, Dedeleit E. Computer simulation and modelling of tumour spheroid growth and their relevance for optimization of fractionated radiotherapy. Strahlenther Onkol 1992;168:354-60.
5. Duechting W, Ginsberg T, Ulmer W. Modelling of radiogenic responses induced by fractionated irradiation in malignant and normal tissue. Stem Cells 1995;13(S1):301-6.
6. Kocher M, Treuer H. Reoxygenation of hypoxic cells by tumour shrinkage during irradiation. A computer simulation. Strahlentherapie und Onkologie 1995;171:219-30.
7. Kocher M, Treuer H, Voges J, Hoevels M, Sturm V, Muller RP. Computer simulation of cytoxic and vascular effects of radiosurgery in solid and necrotic brain metastasis. Radiother Oncol 2000;54:149-56.
8. Swanson KR, Alvord Jr EC, Murray JD. Virtual brain tumours (gliomas) enhance the reality of medical imaging and highlight inadequacies of current therapy. Br J Cancer 2002;86:14-8.
9. Mandonnet E, Delattre JY, Tanguy ML, Swanson KR, Carpentier AF, Duffau H, et al. Continuous growth of mean tumor diameter in a subset of grade II gliomas. Ann Neurol 2003;53:524-8.
10. Swanson KR, Bridge C, Murray JD, Alvord Jr EC. Virtual and real brain tumors: using mathematical modelling to quantify glioma growth and invasion. J Neurol Sci 2003;216:1-10.
11. Byrne H, Matthews P. Asymetric growth of avascular solid tumours: exploiting symmetries. IMA J Mathematics Applied in Medicine and Biology 2002;19:1-29.
12. Alarcon T, Byrne HM, Maini PK. A cellular automaton model for tumour growth in inhomogeneous environment. J Theor Biol 2003;225:257-74.
13. Alarcon T, Byrne HM, Maini PK. Towards whole-organ modelling of tumour growth. Prog Biophys Mol Biol 2004;85:451-72.
14. Alarcon T Byrne HM, Maini PK. A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells. J Theor Biol 2004;229:395-411.
15. Stamatakos G, Dionysiou D, Nikita K, Zambogiou N, Baltas D, Pissakas G, et al. In vivo tumour growth and response to radiation therapy: a novel algorithmic description. Int J Radiat Oncol Biol Phys 2001;51 Suppl. 1:240.
16. Stamatakos G, Zacharaki E, Makropoulou M, Mouravliansky N, Marsh A, Nikita K, et al. Modelling tumour growth and irradiation response in vitro - a combination of high-performance computing and web based tedmologies including VRML visualization. IEEE Trans Inform Tech Biomed 2001;5:279-89.
17. Stamatakos GS, Dionysiou DD, Zacharaki EI, Mouravliansky NA, Nikita KS, Uzunoglu NY. In Silico radiation oncology: combining novel simulation algorithms with current visualization techniques. Proceedings of the IEEE 2002;90:(11).
18. Werner-Wasik M, Scott CB, Nelson DF, Gaspar LE, Murray KJ, Fischbach JA, et al. Final report of a phase I/II trial of hyperfractionated and accelerated hyperfractionated radiation therapy with carmustine for adults with supratentorial malignant gliomas. Radiation Oncology Therapy Group Study 83-02. Cancer 1996;77:1535-43.
19. Goldman E. The growth of malignant disease in man and the lower animals with special reference to the vascular system. Lancet 1907;2:1236-40.
20. Ide AG, Baker NH, Warren SL. Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. Am J Radiol 1939;42:891-9.
21. Algire GH, Chalkey HW. Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants. J Natl Cancer Inst USA 1945;6:73-85.
22. Greenblatt M, Shubik P. Tumour angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique. J Natl Cancer Inst 1968;41:111-24.
23. Ehrmann RL, Knoth M. Choriocarcinoma: transfilter stimulation of vasoproliferation in the hamster cheek pouch studied by light and electron microscopy. J Natl Cancer Inst 1968;41:1329-41.
24. Patan S, Munn LL, Jain RK. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumour angiogenesis. Microvasc Res 1996;51:260-72.
25. Asahara T, Kalka C, Isner JM. Stem cell therapy and gene transfer for regeneration. Gene Ther 2000;7-451-7.
26. Rafii S. Circulating endothelial precursors: mystery, reality, and promise. J Clin Invest 2000;105:17-9.
27. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2002;407:249-59.
28. Baish JW, Jain RF. Fractals and cancer. Cancer Res 2000;60:3683-8.
29. Helmlinger G Yuan F Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumours in vivo: high-resolution measurements reveal a lack of correlation. Nat Med 1997;3:177-82.
30. Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, et al. Regulation of transport pathways in tumour vessels: role of tumour type and microenvironment. Proc Natl Acad Sci USA 1998;95:4607-12.
31. Hashizume H, Baluk P, Morikawa S, McLean JW, Thurston G, Roberge S, et al. Openings between defective endothelial cells explain tumour vessel leakiness. Am J Pathol 2000;156:1363-80.
32. Michelson S, Leith JT. Positive feedback and angiogenesis in tumour growth control. Bull Math Biol 1997;59:233-54.
33. Horsman MR, Overgaard J. The oxygen effect and tumour microenvironment. In: Steel GG, editor. Basic Clinical Radiobiology. 3rd edition, London UK: Hodder Arnold, 2002:158-168.
34. Palcic B, Skarsgard LD. Reduced oxygen enhancement ratio at low doses of ionizing radiation. Radiat Res 1984;100:328-39.
35. Revesz L, Palcic B. Radiation dose dependence of the sensitization by oxygen and oxygen mimic sensitizers. Acta Radiol Oncol 1985;24:209-17.
36. Beppu T, Kamada K, Yoshida Y, Arai H, Ogasawara K, Ogawa A. Change of oxygen pressure in glioblastoma tissue under various conditions. Neurooncol 2002;58:47-52.
37. Potapov AA, Rapman I, Liass FM, Manevich AZ, Iarmonenko SP. Oxygenation of glioblastomas and normal brain tissue during radiation therapy. Med Radiol (Mosk) 1983;28:21-4.
38. Groshar D, McEwan AJ, Parliament MB, Rtasun RC, Golberg LE, Hoskinson M, et al. Imaging tumour hypoxia and tumour perfusion. J Nucl Med 1993;34:885-8.
39. Yetkin FZ Mendelsohn D. Hypoxia imaging in brain tumours. Neuroimaging Clin N Am 2002;12:537-52.
40. Valk PE, Mathis CA, Prados MD, Gilbert JC, Budinger TF. Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole. J Nucl Med 1992;33:2133-7.
41. Leenders KL. PET: blood flow and oxygen consumption in brain tumours. J Neurooncol 1994;22:269-73.
42. Nygren J, Ahstrom G. The oxygen effect in permeabilized and histone-depleted cells: an enhanced OER for DNA double-strand breaks compared to single-strand breaks is abolished by soluble scavengers. Int J Radiat Biol 1997;72:163-70.
43. Stuschke M, Budach V, Budach W, Feldmann HJ, Sack H. Radioresponsiveness sublethal damage repair and stem cell rate in spheroids from three human tumour lines: comparison with xenograft data. Int J Radiat Oncol Biol Phys 1992;24:119-26.
44. Speke A, Hill R. the effects of clamping and reoxygenation of repopulation during fractionated irradiation. Int J Radiat Biol 1995;31:857-63.
45. Perez C, Brady L, Roti Roti J. Overview. In: Perez C, Brady L, editors. Principles and practice of radiation oncology. Philadelphia, PA: Lippincott-Raven, 1998:10.
46. Nahum A, Sanchez-Nieto B. Tumour control probability modelling: basic principles and applications in treatment planning. Phys Med 2001;Suppl. 2:13-23.
47. Hoshino T, Wilson CB, Rosenblum ML, Barker MJ. Chemotherapeutic implications of growth fraction and cell cycle time in glioblastomas. Neurosurg 1975;43:127-35.
48. Crafts DC, Hoshino T, Wilson CB. Current status of population kinetics in gliomas. Bull Cancer 1977;64:115-24.
49. Hoshino T, Wilson CB. Cell kinetic analyses of human malignant brain tumours (gliomas). Cancer 1979;44:956-62.
50. Pertuiset B, Dougherty D, Cromeyer C, Hoshino T, Berger M, Rosenblum MLJ. Stem cell studies of human malignant brain tumours. Part 2: Proliferation kinetics of brain-tumour cells in vitro in early-passage cultures. Neurosurg 1985;63:426-32.
51. Salmon ES, Sartorelli AC. Cancer chemotherapy. In: Katzung BG, editor. Basic and clinical pharmacology. USA: Lange Medical Books/McGraw-Hill, 2001:926.
52. Haas-Kogan DA, Yount G, Haas M, Levi D, Kogan SS, Hu L, et al. p53-dependent G, arrest and p53 independent apoptosis influence the radiobiologic response of glioblastoma. Int J Radiat Oncol Biol Phys 1995;36:95-103.
53. Jones B, Bleasdale C. Influence of tumour regression and clonogen repopulation on tumour control by brachytherapy. In: Baier K, Baltas D, editors. Modelling in clinical radiobiology Freiburg, Germany: Albert-Ludwigs-University, Freiburg Oncology Series, Monograph 1997;2:116-26.
54. Antipas V, Dale RG, Coles IP. A theoretical investigation into the role of tumour radiosensitivity, clonogen repopulation, tumour shrinkage and radionuclide RBE in permanent brachytherapy implants of 125-I and 103-Pd. Phys Med Biol 2001;46:2557-69.
55. Webb S. Optimum parameters in a model for tumour-control probability including interpatient heterogeneity. Phys Med Biol 1994;39:1895-914.
56. Webb S, Nahum AE. A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density. Phys Med Biol 1993;38:653-66.
57. Brahme A, Ågren AK. Optimal dose distribution for eradication of heterogeneous tumours. Acta Radiol Oncol 1987;26:377-85.
58. Begg AC, Steel GG. Cell proliferation and growth rate of tumour. In: Steel GG, editor. Basic Clinical Radiobiology. London, UK: Hodder Arnold 2002:8-22.
59. Ebert MA, Hoban W. Some characteristics of tumour control probability for heterogeneous tumours. Phys Med Biol 1996;41:2125-33.
60. Steel GG. Cell survival as a determinant of tumour response. In: Steel GG, editor. Basic Clinical Radiobiology. London, UK: Hodder Arnold 2002:52-63.
61. Horsman MR, Overgaard J. Overcoming tumour radioresistance resulting from hypoxia. In: Steel GG, editor. Basic Clinical Radiobiology. London, UK: Hodder Arnold 2002:169-181.
62. Knisely JP, Rockwell S. Importance of hypoxia in the biology and treatment of brain tumours. Neuroimaging Clin N Am 2002;12:525-36.
63. Taghian A, Ramsay J, Allalunis-Turner J, Budach W, Gioioso D, Pardo F, et al. Intrinsic radiation sensistivity may not be the major determinant of the poor clinical outcome of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 1993;25:243-9.