Safety and toxicological evaluation of a novel, standardized 3-O-acetyl-11-keto-β-boswellic acid (AKBA)-enriched Boswellia serrata extract (5-Loxin®)

Toxicology Mechanisms and Methods

Volumn 16, Issue 4, 2006, Pages 199-226

  Lalithakumari, K ^a   Krishnaraju, A V ^a   Sengupta, K ^a   Subbaraju, G V ^a   Chatterjee, A ^b  

^a Laila Research Centre   (India)

^b CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

3 O acetyl 11 keto boswellic Acid (AKBA); 5 Loxin ; 90 day Oral Subchronic Toxicity Study; Acute Dermal Toxicity; Acute Oral Toxicity; Boswellia serrata; DNA Fragmentation; Primary Dermal Irritation; Primary Eye Irritation

Indexed keywords

3 O ACETYL 11 KETO BETA BOSWELLIC ACID; 5 LOXIN; ARACHIDONATE 5 LIPOXYGENASE; BOSWELLIA SERRATA EXTRACT; BOSWELLIC ACID; DNA FRAGMENT; INTERCELLULAR ADHESION MOLECULE 1; MATRIX METALLOPROTEINASE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; AYURVEDA; BODY WEIGHT; BOSWELLIA; BOSWELLIA SERRATA; BRAIN WEIGHT; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; DRUG TOXICITY; ENDOTHELIUM CELL; EVALUATION; FEMALE; GENE EXPRESSION; LD 50; LIVER; MALE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RAT; RAT STRAIN; TOXICITY TESTING;

ANIMALIA; BOSWELLIA; BOSWELLIA SERRATA; ORYCTOLAGUS CUNICULUS;

EID: 33646384973     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376520600620232     Document Type: Article

References (14)

1. Ammon, H. P. T. 1996. Salai Guggal - Boswellia serrata: From a herbal medicine to a non-redox inhibitor of leukotriene biosynthesis. Eur. J. Med. Res. 1:369-370.
2. Ammon, H. P. T. 2002. Boswelliasauren (Inhaltsstoffe des Weihrauchs) als wirksame Prinzipien zur Behandlung chronisch entzundlicher Erkrankungen. Wiener Medizinische Wochenschrift 152:373-378.
3. Ammon, H. P. T., Mack, T., Singh, G. B., and Safayhi, H. 1991. Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata. Planta Med. 57:203-207.
4. Ammon, H. P. T., Safayhi, H., Mack, T., and Sabieraj, J. 1993. Mechanism of antiinflammatory actions of curcumin and boswellic acids. J. Ethnopharmacol. 38:13-119.
5. Bagchi, D., Carryl, O. R., Tran, M. X., Krohn, R. L., Bagchi, D. J., Garg, A., Bagchi, M., Mitra, S., and Stohs, S. J. 1998. Stress, diet and alcohol-induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate. J. Appl. Toxicol. 18:3-13.
6. Boden, S. E., Schweizer, S., Bertsche, T., Dufer, M., Drews, G., and Safayhi, H. 2001. Stimulation of leukotriene synthesis in intact polymorphonuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid. Mol. Pharmacol. 60:267-273.
7. Draize, J. H., Woodward, G., and Calvery, H. O. 1944. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J. Pharmacol. Exper. Ther. 82:377-390.
8. Draize, J. H. 1965. The Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. Dermal Toxicity. Association of Food and Drug Officials of the US, Topeka, KS, pp. 46-59.
9. Gupta, I., Gupta, V., Parihar, A., Gupta, S., Ludtke, R., Safayhi, H., and Ammon, H. P. T. 1998. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur. J. Med. Res. 3:511-514.
10. Gupta, I., Parihar, A., Malhotra, P., Gupta, S., Ludtke, R., Safayhi, H., and Ammon, H. P. T. 2001. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med. 67:391-395.
11. Kay, J. H., and Calandra, J. C. 1962. Interpretation of eye irritation tests. J. Soc. Cosmetic Chem. 13:281-289.
12. Kimmatkar, N., Thawani, V., Hingorani, L., and Khiyani, R. 2003. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee - a randomized double blind placebo controlled trial. Phytomedicine 10:3-7.
13. Roy, S., Khanna, S., Shah, H., Rink, C., Phillips, C., Preuss, H. G., Subbaraju, G. V., Trimurtulu, G., Krishnaraju, A. V., Bagchi, M., Bagchi, D., and Sen, C. K. 2005. Human genome screen to identify the genetic basis of the antiinflammatory effects of Boswellia in microvascular endothelial cells. DNA Cell Biol. 24:244-255.
14. Safayhi, H., Mack, T., Sabieraj, J., Anazodo, M. I., Subramanian, L. R., and Ammon, H. P. T. 1992. Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exper. Ther. 261:1143-1146.