Sulfonyl-containing nucleoside phosphotriesters and phosphoramidates as novel anticancer prodrugs of 5-fluoro-2′-deoxyuridine 5′- monophosphate (FdUMP)

Molecular Pharmaceutics

Volumn 3, Issue 2, 2006, Pages 161-173

  Sun, Yuan Wan ^a   Chen, Kun Ming ^a   Kwon, Chul Hoon ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

elimination; 5 FU; Nucleotide prodrug; Sulfonyl

Indexed keywords

2' DEOXYURIDIN 5' YL' BIS[2 (4 TOLYLSULFONYL)ETHYL]PHOSPHATE; 5 FLUORO 2' DEOXYURIDIN 5' YL BIS[2 (4 TOLYLSULFONYL) 1 METHYLETHYL]PHOSPHATE; 5 FLUORO 2' DEOXYURIDIN 5' YL BIS[2 (4 TOLYLSULFONYL)ETHYL]PHOSPHATE; ANTINEOPLASTIC AGENT; FLOXURIDINE PHOSPHATE DERIVATIVE; FLUOROURACIL DERIVATIVE; NUCLEOSIDE PHOSPHOTRIESTER; O,O' 2' DEOXYURIDIN 5' YL [2 (4 TOLYLSULFONYL)ETHYL]N,N BIS(2 CHLOROETHYL)PHOSPHORAMIDATE; O,O' 2' DEOXYURIDIN 5' YL [2 (4 TOLYLSULFONYL)ETHYL]PHOSPHORAMIDATE; O,O' 5 FLUORO 2' DEOXYURIDIN 5' YL [2 (4 NITROPHENYLSULFONYL)ETHYL]N,N BIS(2 CHLOROETHYL)PHOSPHORAMIDATE; O,O' 5 FLUORO 2' DEOXYURIDIN 5' YL [2 (4 TOLYLSULFONYL)ETHYL]N,N BIS(2 CHLOROETHYL)PHOSPHORAMIDATE; O,O' 5 FLUORO 2' DEOXYURIDIN 5' YL [2 (4 TOLYLSULFONYL)ETHYL]PHOSPHORAMIDATE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; THYMIDINE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN V 79; CONTROLLED STUDY; DRUG DESIGN; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PLASMA; PRIORITY JOURNAL;

AMINATION; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL PROLIFERATION; CRICETINAE; ESTERS; FLUORINE; FLUORODEOXYURIDYLATE; HALF-LIFE; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR STRUCTURE; NUCLEOSIDES; PHOSPHORUS; PRODRUGS; THYMIDINE;

EID: 33646380859     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp0500622     Document Type: Article

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