Modulation of single-chain antibody affinity with temperature-responsive elastin-like polypeptide linkers

Biomacromolecules

Volumn 7, Issue 4, 2006, Pages 999-1004

  Megeed, Zaki ^a   Winters, Ryan M ^a   Yamush, Martin L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOSENSORS; DRUG PRODUCTS; GENETIC ENGINEERING; KINETIC ENERGY; POLYPEPTIDES;

BINDING KINETICS; ELASTIN-LIKE POLYPEPTIDE LINKERS; EQUILIBRIUM AFFINITY; FLEXIBLE PEPTIDE LINKER; GENETICALLY MODIFIED; SINGLE-CHAIN ANTIBODIES; STIMULUS-RESPONSIVE LINKERS;

ANTIBODIES;

ELASTIN; FLUORESCEIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; POLYPEPTIDE;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; EQUILIBRIUM CONSTANT; FEASIBILITY STUDY; GENETIC ENGINEERING; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; ROOM TEMPERATURE; SITE DIRECTED MUTAGENESIS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TEMPERATURE DEPENDENCE;

ANTIBODY AFFINITY; ELASTIN; KINETICS; LIGANDS; PEPTIDES; TEMPERATURE;

EID: 33646376906     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm0507002     Document Type: Article

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