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note
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To test the results of ion exchange, the following test was driven: a few milligrams of the gemini peptides was put in the presence of silver acetate ("cream colored"), in methanol. With methods a and b, the mixture became rapidly dark (less than 30 min), indicating the formation of AgBr and suggesting the presence of residual bromide. On the contrary, the gemini peptides synthesized via method c mixed with silver acetate remained clear, showing negligible amounts of residual bromide.
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note
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Since the molecules with C16 were too soluble and did not have a clear collapse and C22 had a phase transition that made it difficult to compare the different peptide lengths (Figure 10), we focused specifically on the systems with C18 and C20.
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39
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33646371093
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note
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Acetate counterion is chosen for its low affinity with ammonium headgroups (manuscript in preparation); thus the exchange by the oligopeptides in solution will be more efficient.
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