Using HLA-transgenic mice to identify immunodominant human CD8+ T cell epitopes-Does (genome) size matter?

Immunology Letters

Volumn 105, Issue 1, 2006, Pages 97-98

  Terajima, Masanori ^a   Ennis, Francis A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

CD8+ T cell epitopes; HLA transgenic mice; Vaccinia virus, Smallpox

Indexed keywords

B7 ANTIGEN; EPITOPE; HLA A1 ANTIGEN; HLA A2 ANTIGEN; HLA A24 ANTIGEN; HLA A3 ANTIGEN; HLA ANTIGEN CLASS 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SMALLPOX VACCINE;

ANTIBODY COMBINING SITE; ANTIGEN BINDING; ANTIGEN BINDING CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; CD8+ T LYMPHOCYTE; COMPUTER PREDICTION; CYTOTOXIC T LYMPHOCYTE; DNA VIRUS; ENZYME LINKED IMMUNOSPOT ASSAY; EPITOPE MAPPING; IMMUNOSTIMULATION; IN VITRO STUDY; INFLUENZA VIRUS A; LETTER; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; OPEN READING FRAME; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; SCREENING TEST; SPLEEN CELL; TRANSGENIC MOUSE; VACCINIA VIRUS; VIRUS GENOME;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; GENETIC VECTORS; GENOME, HUMAN; GENOME, VIRAL; HLA ANTIGENS; HUMANS; IMMUNODOMINANT EPITOPES; MICE; MICE, TRANSGENIC; VACCINES, SYNTHETIC; VACCINIA VIRUS;

EID: 33646363787     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2006.01.007     Document Type: Letter

References (14)

1. Pascolo S. HLA class I transgenic mice: development, utilisation and improvement. Expert Opin Biol Ther 5 (2005) 919-938
2. Man S., Newberg M.H., Crotzer V.L., Luckey C.J., Williams N.S., Chen Y., et al. Definition of a human T cell epitope from influenza A non-structural protein 1 using HLA-A2.1 transgenic mice. Int Immunol 7 (1995) 597-605
3. Shirai M., Arichi T., Nishioka M., Nomura T., Ikeda K., Kawanishi K., et al. CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1. J Immunol 154 (1995) 2733-2742
4. + T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses. J Exp Med 197 (2003) 927-932
5. + T cell epitopes conserved among vaccinia and variola viruses restricted by common MHC class I molecules, HLA-A2 or HLA-B7. Human Immunol: in press.
6. Drexler I., Staib C., Kastenmuller W., Stevanovic S., Schmidt B., Lemonnier F.A., et al. Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines. Proc Natl Acad Sci USA 100 (2003) 217-222
7. + T-cell peptide epitope of vaccinia and variola viruses. J Virol 78 (2004) 7052-7060
8. Oseroff C., Kos F., Bui H.H., Peters B., Pasquetto V., Glenn J., et al. HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation. Proc Natl Acad Sci USA 102 (2005) 13980-13985
9. Pasquetto V., Bui H.H., Giannino R., Mirza F., Sidney J., Oseroff C., et al. HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products. J Immunol 175 (2005) 5504-5515
10. Jing L., Chong T.M., McClurkan C.L., Huang J., Story B.T., and Koelle D.M. Diversity in the acute CD8 T cell response to vaccinia virus in humans. J Immunol 175 (2005) 7550-7559
11. +-derived dendritic cell vaccination: a phase I trial in metastatic melanoma. Clin Cancer Res 10 (2004) 5381-5390
12. Smith C.L., Mirza F., Pasquetto V., Tscharke D.C., Palmowski M.J., Dunbar P.R., et al. Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia ankara. J Immunol 175 (2005) 8431-8437
13. Moss B. Poxviridae: the viruses and their replication. In: Knipe D.M., and Howley P.M. (Eds). Fields Virology vol. 2 (2001), Lippincott Wiliams & Wilkins, Philadelphia 2849-2883
14. Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., and Paoletti E. The complete DNA sequence of vaccinia virus. Virology 179 (1990) 247-266 517-63