Characterization of experimentally induced post-traumatic osteoarthritis in the medial femorotibial joint of horses

American Journal of Veterinary Research

Volumn 67, Issue 3, 2006, Pages 433-447

  Bolam, Courtney J ^a,c   Hurtig, Mark B ^a   Cruz, Antonio ^a   McEwen, Beverly J E ^b  

^a UNIVERSITY OF GUELPH   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

^c Wisconsin Equine Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN 6 SULFATE; COLLAGENASE; GLYCOSAMINOGLYCAN POLYSULFATE; GLYCOSAMINOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL LAMENESS; ANIMAL MODEL; ARTICLE; CARBOHYDRATE ANALYSIS; CARTILAGE; CONTROLLED STUDY; DISEASE SEVERITY; EXPLANT; FEMUR CONDYLE; HISTOPATHOLOGY; HORSE DISEASE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; JOINT INJURY; KNEE OSTEOARTHRITIS; MICROSCOPY; NICK END LABELING; NONHUMAN; PAIN THRESHOLD; PATHOGENESIS; RADIOGRAPHY; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SYNOVIAL FLUID; TISSUE CULTURE; ANIMAL; ANIMAL DISEASE; CLINICAL TRIAL; HINDLIMB; HORSE; JOINT; METABOLISM; OSTEOARTHRITIS; PATHOLOGY;

ANIMALIA; EQUIDAE;

ANIMALS; GLYCOSAMINOGLYCANS; HINDLIMB; HORSE DISEASES; HORSES; JOINTS; OSTEOARTHRITIS; SYNOVIAL FLUID;

EID: 33646343006     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.67.3.433     Document Type: Article

References (82)

1. Fubini SL, Erb HN, Freeman KP, et al. Prognostic factors affecting survival of 507 horses with joint disease: (1983 to 1990). Can J Vet Res 1999;63:253-260.
2. Frisbie DD, McIlwraith CW. Evaluation of gene therapy as a treatment for equine traumatic arthritis and osteoarthritis. Clin Orthop Relat Res 2000;379(suppl 379):S273-S287.
3. Norrdin RW, Bay BK, Drews MJ, et al. Overload arthrosis: strain patterns in the equine metacarpal condyle. J Musculoskelet Neuronal Interact 2001;1:357-362.
4. Martel-Pelletier J. Pathophysiology of osteoarthritis. Osteoarthritis Cartilage 1998;6:374-376.
5. Buckwalter JA, Stanish WD, Rosier RN, et al. The increasing need for nonoperative treatment of patients with osteoarthritis. Clin Orthop Relat Res 2001;385:36-45.
6. Buckwalter JA, Saltzman C, Brown T. The impact of osteoarthritis: implications for research. Clin Orthop Relat Res 2004;427(suppl 427):S6-S15.
7. Carter DR, Beaupre GS, Wong M, et al. The mechanobiology of articular cartilage development and degeneration. Clin Orthop Relat Res 2004;427(suppl 427):S69-S77.
8. Felson DT, Schurman DJ. Risk factors for osteoarthritis: understanding joint vulnerability. Clin Orthop 2004;427(suppl 427):S16-S21.
9. Aigner T, McKenna L. Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci 2002;59:5-18.
10. Marcel-Pelletier J. Pathophysiology of osteoarthritis. Osteoarthritis Cartilage 2004;12:S31-S33.
11. Colwell CW Jr, D'Lima DD, Hoenecke HR, et al. In vivo changes after mechanical injury. Clin Orthop Relat Res 2001;391(suppl 391):S116-S123.
12. Duda GN, Eilers M, Loh L, et al. Chondrocyte death precedes structural damage in blunt impact trauma. Clin Orthop Relat Res 2001;393:302-309.
13. Zhang H, Vrahas MS, Baratta RV, et al. Damage to rabbit femoral articular cartilage following direct impacts of uniform stresses: an in vitro study. Clin Biomech 1999;14:543-548.
14. Buckwalter JA. Sports, joint injury, and posttraumatic osteoarthritis. J Orthop Sports Phys Ther 2003;33:578-588.
15. Borrelli J Jr, Ricci WM. Acute effects of cartilage impact. Clin Orthop 2004;423:33-39.
16. Burr DB, Radin EL. Microfractures and microcracks in subchondral bone: are they relevant in osteoarthrosis? Rheum Dis Clin North Am 2003;29:675-685.
17. Kawcak CE, McIlwraith CW, Norrdin RW, et al. The role of subchondral bone in joint disease: a review. Equine Vet J 2001;33:120-126.
18. Buckwalter JA. Articular cartilage injuries. Clin Orthop 2002;402:21-37.
19. Radin EL. Subchondral bone changes and cartilage damage. Equine Vet J 1999;31:94-95.
20. Bollet AJ. Edema of the bone marrow can cause pain in osteoarthritis and other diseases of bone and joints. Ann Intern Med 2001;134:591-592.
21. Braman JP, Bruckner JD, Clark JM, et al. Articular cartilage adjacent to experimental defects is subject to atypical strains. Clin Orthop 2005;430:202-207.
22. Ewers BJ, Newberry WN, Haut RC. Chronic softening of cartilage without thickening of underlying bone in a joint trauma model. J Biomech 2000;33:1689-1694.
23. Ewers BJ, Weaver BT, Haut RC. Impact orientation can significantly affect the outcome of a blunt impact to the rabbit patellofemoral joint. J Biomech 2002;35:1591-1598.
24. Munk PL, Vellet AD. Lesions of cartilage and bone around the knee. Top Magn Reson Imaging 1993;5:249-262.
25. Skioldebrand E, Lorenzo P, Zunino L, et al. Concentration of collagen, aggrecan and cartilage oligomeric matrix protein (COMP) in synovial fluid from equine middle carpal joints. Equine Vet J 2001;33:394-402.
26. Van den Boom R, Brama PA, Kiers GH, et al. Assessment of the effects of age and joint disease on hydoxyproline and glycosaminoglycan concentrations in synovial fluid from the metacarpophalangeal joint of horses. Am J Vet Res 2004;65:296-302.
27. Frisbie DD, Ray CS, Ionescu M, et al. Measurement of synovial fluid and serum concentrations of the 846 epitope of chondroitin sulfate and of carboxy propeptides of type II procollagen for diagnosis of osteochondral fragmentation in horses. Am J Vet Res 1999;60:306-309.
28. Fuller CJ, Barr AR, Sharif M, et al. Cross-sectional comparison of synovial fluid biochemical markers in equine osteoarthritis and the correlation of these markers with articular cartilage damage. Osteoarthritis Cartilage 2001;9:49-55.
29. Fuller CJ, Barr AR, Dieppe PA, et al. Variation of an epitope of keratan sulphate and total glycosaminoglycans in normal equine joints. Equine Vet J 1996;28:490-493.
30. Todhunter RJ, Yeager AE, Freeman KP, eL al. Keratan sulfate as a marker of articular cartilage catabolism and joint treatment in ponies. Am J Vet Res 1993;54:1007-1016.
31. Palmer JL, Bertone AL, McClain H. Assessment of glycosaminoglycan concentration in equine synovial fluid as a marker of joint disease. Can J Vet Res 1995;59:205-212.
32. Alwan WH, Carter SD, Bennett D, et al. Glycosaminoglycans in horses with osteoarthritis. Equine Vet J 1991;23:44-47.
33. Little CB, Hilbert BJ, Wickstrom S, et al. Quantitative microanalysis of equine synovial fluid glycoaminoglycan concentration. Am J Vet Res 1990;51:1534-1539.
34. Alwan WH, Carter SD, Bennett D, et al. Cartilage break-down in equine osteoarthritis: measurement of keratan sulphate by an ELISA system. Res Vet Sci 1990;49:56-60.
35. Todhunter RJ, Fubini SL, Freeman KP, et al. Concentrations of keratan sulfate in plasma and synovial fluid from clinically normal horses and horses with joint disease. J Am Vet Med Assoc 1997;210:369-374.
36. Oke SL, Hurtig MB, Keates RA, et al. Assessment of three variations of the 1,9-dimethylmethylene blue assay for measurement of sulfated glycosaminoglycan concentration in equine synovial fluid. Am J Vet Res 2003;64:900-906.
37. Jouglin M, Robert C, Valette JP, et al. Metalloproteinases and tumor necrosis factor-alpha activities in synovial fluid of horses: correlation with articular cartilage alterations. Vet Res 2000;31:507-515.
38. Firth EC, Delahunt J, Wichtel JW, et al. Galloping exercise induces regional changes in bone density in the third and radiocarpal bones of Thoroughbred horses. Equine Vet J 1999;31:111-115.
39. Anastasiou A, Skioldebrand E, Ekman S, et al. Ex vivo magnetic resonance imaging of the distal row of equine carpal bones: assessment of bone sclerosis and cartilage damage. Vet Radiol Ultrasound 2003;44:501-512.
40. Norrdin RW, Kawcak CE, Capwell BA, et al. Subchondral bone failure in an equine model of overload arthrosis. Bone 1998;22:133-139.
41. Walmsley JP. Vertical tears of the cranial horn of the meniscus and its cranial ligament in the equine femorotibial joint: 7 cases and their treatment by arthroscopic surgery. Equine Vet J 1995;27:20-25.
42. Prades M, Grant BD, Turner TA, et al. Injuries to the cranial cruciate ligament and associated structures: summary of clinical, radiographic, arthroscopic and pathological findings from 10 horses. Equine Vet J 1989;21:354-357.
43. Vatistas NJ, Wright IM, Dyson SJ. Comparison of arthroscopy and arthrotomy for the treatment of osteochondritic lesions in the femoropatellar joint of horses. Vet Rec 1995;137:629-632.
44. Von Rechenberg B, McIlwraith CW, Auer JA. Cystic bone lesions in horses and humans: a comparative review. Vet Comp Orthop Traumatol 1998;11:8-18.
45. Kold SE, Hickman J. An experimental study of the healing process of equine chondral and osteochondral defects. Equine Vet J 1986;18:18-24.
46. Ray CS, Baxter GM, McIlwraith CW, et al. Development of subchondral cystic lesions after articular cartilage and subchondral bone damage in young horses. Equine Vet J 1996;28:225-232.
47. Jeffcott LB, Kold SE. Aspects of the pathology of stifle bone cysts in the horse. Equine Vet J 1983;15:304-311.
48. Walmsley JP. The stifle. In: Ross MW, Dyson SJ eds. Diagnosis and management of lameness in the horse. St Louis: Elsevier Science, 2003;455-470.
49. Scott GS, Crawford WH, Colahan PT. Arthroscopic findings in horses with subtle radiographic evidence of osteochondral lesions of the medial femoral condyle: 15 cases (1995-2002). J Am Vet Med Assoc 2004;224:1821-1826.
50. Schneider RK, Jenson P, Moore RM. Evaluation of cartilage lesions on the medial femoral condyle as a cause of lameness in horses: 11 cases (1988-1994). J Am Vet Med Assoc 1997;210:1649-1652.
51. Haut RC, Ide TM, Decamp CE. Mechanical responses of the rabbit patellofemoral joint to blunt impact. J Biomech Eng 1995;117:402-408.
52. Thompson RC Jr, Gegema TR Jr, Lewis JL, et al. Osteoarthrotic changes after acute transarticular load. J Bone Joint Surg Am 1991;73:990-1001.
53. Donohue JM, Buss D, Gegema TR Jr, et al. The effects of indirect blunt trauma on adult canine articular cartilage. J Bone Joint Surg Am 1983;65:948-957.
54. DiMicco MA, Patwari P, Siparsky PN, et al. Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis Rheum 2004;50:840-848.
55. Vrahas MS, Mithoefer K, Joseph D. The long-term effects of articular impaction. Clin Orthop 2004;423:40-43.
56. Ewers BJ, Dvoracek-Driksna D, Orth MW, et al. The extent of matrix damage and chondrocyte death in mechanically traumatized articular cartilage explants depends on rate of loading. J Orthop Res 2001;19:779-784.
57. Jeffrey JE, Gregory DW, Aspden RM. Matrix damage and chondrocyte viability following a single impact load on articular cartilage. Arch Biochem Biophys 1995;322:87-96.
58. Newberry WN, Zukosky DK, Haut RC. Subfracture insult to a knee joint causes alterations in the bone and in the functional stiffness of overlying cartilage. J Orthop Res 1997;15:450-455.
59. Hurtig MB, Novak K, McPherson R, et al. Osteochondral dowel transplantation for repair of focal defects in the knee: an outcome study using an ovine model. Vet Surg 1998;27:5-16.
60. American Association of Equine Practitioners (AAEP). Lameness scale. Definition and classification of lameness. In: Guide to veterinary services for horse shows. 7th ed. Lexington, Ky: American Association of Equine Practioners, 1999.
61. Lewis RD. A retrospective study of diagnostic and surgical arthroscopy of the equine femorotibial joints, in Proceedings. 33rd Annu Meeting Am Assoc Equine Pract 1987;887-893.
62. International Cartilage Research Society Web site. ICRS cartilage injury evaluation package. Available at: www.cartilage.org/files/ICRS_evaluation.pdf. Accessed May 11, 2005.
63. Peterfy CG, Guermazi A, Zaim. S, et al. Whole-organ magnetic resonance imaging score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 2004;12:177-190.
64. Bae WC, Temple MM, Amiel D, et al. Indentation testing of human cartilage: sensitivity to articular surface degeneration. Arthritis Rheum 2003;48:3382-3394.
65. Mak AF, Lai WM, Mow VC. Biphasic indentation of articular cartilage - I. Theoretical analysis. J Biomech 1987;20:703-714.
66. Mow VC, Gibbs MC, Lai WM, et al. Biphasic indentation of articular cartilage - II. A numerical algorithm and an experimental study. J Biomech 1989;22:853-861.
67. van der Sluijs JA, Geesink RG, van der Linden AJ, et al. The reliability of the Mankin score for osteoarthritis. J Orthop Res 1992;10:58-61.
68. Shoukri MM, Edge VL. Statistical methods for health sciences. Boca Raton, Fla: CRC Press Inc, 1996;23-26.
69. Cohen NP, Foster RJ, Mow VC. Composition and dynamics of articular cartilage: structure, function and maintaining healthy state. J Orthop Sports Phys Ther 1998;28:203-215.
70. Simmons EJ, Bertone AL, Weisbrode SE. Instability-induced osteoarthritis in the metacarpophalangeal joint of horses. Am J Vet Res 1999;60:7-13.
71. Foland JW, McIlwraith CW, Trotter GW, et al. Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments. Vet Surg 1994;23:369-376.
72. Ewers BJ, Haut RC. Polysulphated glycosaminoglycan treatments can mitigate decreases in stiffness of articular cartilage in a traumatized animal joint. J Orthop Res 2000;18:756-761.
73. D'Lima DD, Hashimoto S, Chen PC, et al. impact of mechanical trauma on matrix and cells. Clin Orthop Relat Res 2001;391(suppl 391):S90-S99.
74. Hurtig MB, Fretz PB, Doige CE, et al. Effects of lesion size and location on equine articular cartilage repair. Can J Vet Res 1988;52:137-146.
75. Desjardins MR, Hurtig MB, Palmer NC. Heterotopic transfer of fresh and cryopreserved autogenous articular cartilage in the horse. Vet Surg 1991;20:434-445.
76. Hascall VC, Glant TT. Proteoglycan epitopes as potential markers of normal and pathologic cartilage metabolism. Arthritis Rheum 1987;30:586-588.
77. Adams ME, Matyas JR, Huang D, et al. Expression of proteoglycans and collagen in the hypertrophic phase of experimental arthritis. J Rheumatol Suppl 1995;43:94-97.
78. Laverty S, O'Kouneff S, Ionescu M, et al. Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis. J Orthop Res 2002;20:1282-1289.
79. Durr HR, Martin H, Pellengahr C, et al. The cause of subchondral bone cysts in osteoarthrosis. Acta Orthop Scand 2004;75:554-558.
80. Cantley CEL, Firth EC, Delahunt JW, et al. Naturally occurring osteoarthritis in the metacarpophalangeal joints of wild horses. Equine Vet J 1999;31:73-81.
81. Brommer H, van Weeren PR, Brama PA. New approach for quantitative assessment of articular cartilage in horses with osteoarthritis. Am J Vet Res 2003;64:83-87.
82. Pritzker KPH, Gay S, Jimenez SA et al, Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage 2006;14:13-29.