메뉴 건너뛰기




Volumn 77, Issue 3, 2006, Pages 370-384

Short-term side effects of 0.2% alcohol-free chlorhexidine mouthrinse used as an adjunct to non-surgical periodontal treatment: A double-blind clinical study

Author keywords

Chlorhexidine; Side effects

Indexed keywords

ALCOHOL; CHLORHEXIDINE GLUCONATE; PLACEBO; CHLORHEXIDINE; DRUG DERIVATIVE; TOPICAL ANTIINFECTIVE AGENT;

EID: 33646337160     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2006.050141     Document Type: Article
Times cited : (94)

References (58)
  • 2
    • 0023023188 scopus 로고
    • Chlorhexidine digluconate - An agent for chemical plaque control and prevention of gingival inflammation
    • Lang NP, Brecx MC. Chlorhexidine digluconate - An agent for chemical plaque control and prevention of gingival inflammation. J Periodontal Res 1986; (Suppl.):74-89.
    • (1986) J Periodontal Res , Issue.SUPPL. , pp. 74-89
    • Lang, N.P.1    Brecx, M.C.2
  • 3
    • 0023675247 scopus 로고
    • Quality specific taste impairment following the application of CHX gluconate mouthrinse
    • Lang NP, Catalanotto FA, Knopfli RU, Antczak AAA. Quality specific taste impairment following the application of CHX gluconate mouthrinse. J Clin Periodontol 1988;15:43-48.
    • (1988) J Clin Periodontol , vol.15 , pp. 43-48
    • Lang, N.P.1    Catalanotto, F.A.2    Knopfli, R.U.3    Antczak, A.A.A.4
  • 5
    • 0035117296 scopus 로고    scopus 로고
    • Reduction of saltiness and bitterness after a chlorhexidine rinse
    • Breslin PA, Tharp CD. Reduction of saltiness and bitterness after a chlorhexidine rinse. Chem Senses 2001;26:105-116.
    • (2001) Chem Senses , vol.26 , pp. 105-116
    • Breslin, P.A.1    Tharp, C.D.2
  • 6
    • 0004437923 scopus 로고    scopus 로고
    • Pharmacological control of dental caries and periodontal disease
    • In: Seymour RA, Meechan JG, Yates MS, eds. Oxford: Oxford University Press
    • Seymour RA, Meechan JG, Yates MS. Pharmacological control of dental caries and periodontal disease. In: Seymour RA, Meechan JG, Yates MS, eds. Pharmacology and Dental Therapeutics. Oxford: Oxford University Press; 1999:179-196.
    • (1999) Pharmacology and Dental Therapeutics , pp. 179-196
    • Seymour, R.A.1    Meechan, J.G.2    Yates, M.S.3
  • 7
    • 0020076241 scopus 로고
    • The effect of single morning and evening rinses of chlorhexidine on the development of tooth staining and plaque accumulation. A blind crossover trial
    • Addy M, Moran J, Davies RM, Lewis A. The effect of single morning and evening rinses of chlorhexidine on the development of tooth staining and plaque accumulation. A blind crossover trial. J Clin Periodontol 1982;9:134-140.
    • (1982) J Clin Periodontol , vol.9 , pp. 134-140
    • Addy, M.1    Moran, J.2    Davies, R.M.3    Lewis, A.4
  • 8
    • 0025037810 scopus 로고
    • Antifungal therapy in oropharyngeal mycotic infections
    • Epstein JB. Antifungal therapy in oropharyngeal mycotic infections. Oral Surg Oral Med Oral Pathol 1990; 69:32-41.
    • (1990) Oral Surg Oral Med Oral Pathol , vol.69 , pp. 32-41
    • Epstein, J.B.1
  • 9
    • 84984520640 scopus 로고
    • Chlorhexidine as a denture disinfectant in the treatment of denture stomatitis
    • Budtz-Jorgensen E, Löe H. Chlorhexidine as a denture disinfectant in the treatment of denture stomatitis. Scand J Dent Res 1972;80:457-464.
    • (1972) Scand J Dent Res , vol.80 , pp. 457-464
    • Budtz-Jorgensen, E.1    Löe, H.2
  • 10
    • 0017126305 scopus 로고
    • Two years use of chlorhexidine in man. (I) General design and clinical effects
    • Löe H, Schiott CR, Karring T. Two years use of chlorhexidine in man. (I) General design and clinical effects. J Periodontal Res 1976;11:135-144.
    • (1976) J Periodontal Res , vol.11 , pp. 135-144
    • Löe, H.1    Schiott, C.R.2    Karring, T.3
  • 11
    • 0019723580 scopus 로고
    • The use of polymethylmethacrylate to compare the adsorption and staining reaction of some cationic antiseptics
    • Addy M, Roberts WR. The use of polymethylmethacrylate to compare the adsorption and staining reaction of some cationic antiseptics. J Periodontol 1981; 52:380-385.
    • (1981) J Periodontol , vol.52 , pp. 380-385
    • Addy, M.1    Roberts, W.R.2
  • 12
    • 0033628770 scopus 로고    scopus 로고
    • Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate
    • Grundemann LJ, Timmerman MF, Ijzerman Y, et al. Stain, plaque and gingivitis reduction by combining chlorhexidine and peroxyborate. J Clin Periodontol 2000;27:9-15.
    • (2000) J Clin Periodontol , vol.27 , pp. 9-15
    • Grundemann, L.J.1    Timmerman, M.F.2    Ijzerman, Y.3
  • 13
    • 0020111972 scopus 로고
    • In vitro studies into the release of chlorhexidine acetate, prednisolone sodium phosphate, and prednisolone alcohol from cold cure denture base acrylic
    • Addy M, Thaw M. In vitro studies into the release of chlorhexidine acetate, prednisolone sodium phosphate, and prednisolone alcohol from cold cure denture base acrylic. J Biomed Mater Res 1982;16:145-157.
    • (1982) J Biomed Mater Res , vol.16 , pp. 145-157
    • Addy, M.1    Thaw, M.2
  • 14
    • 0013617830 scopus 로고    scopus 로고
    • Antiseptics in periodontal therapy
    • In: Lindhe J, Karring T, Lang NP, eds. Copenhagen: Munksgaard
    • Addy M. Antiseptics in periodontal therapy. In: Lindhe J, Karring T, Lang NP, eds. Clinical Periodontology and Implant Dentistry. Copenhagen: Munksgaard; 1998:476-478.
    • (1998) Clinical Periodontology and Implant Dentistry , pp. 476-478
    • Addy, M.1
  • 16
    • 0029298147 scopus 로고
    • Relationship between oral pain and ethanol concentration in mouthrinses
    • Bolanowski SJ, Gescheider GA, Sutton SVW. Relationship between oral pain and ethanol concentration in mouthrinses. J Periodontal Res 1995;30:192-197.
    • (1995) J Periodontal Res , vol.30 , pp. 192-197
    • Bolanowski, S.J.1    Gescheider, G.A.2    Sutton, S.V.W.3
  • 17
    • 0032253427 scopus 로고    scopus 로고
    • Efficacy of an alcohol-free chlorhexidine mouthrinse as an antimicrobial agent
    • Eldridge KR, Finnie SF, Stephens JA, et al. Efficacy of an alcohol-free chlorhexidine mouthrinse as an antimicrobial agent. J Prosthet Dent 1998;80:685-690.
    • (1998) J Prosthet Dent , vol.80 , pp. 685-690
    • Eldridge, K.R.1    Finnie, S.F.2    Stephens, J.A.3
  • 18
    • 0035256011 scopus 로고    scopus 로고
    • Alcohol-free mouthrinse solutions to reduce supragingival plaque regrowth and vitality. A controlled clinical study
    • Arweiler NB, Netuschil L, Reich E. Alcohol-free mouthrinse solutions to reduce supragingival plaque regrowth and vitality. A controlled clinical study. J Clin Periodontol 2001;28:168-174.
    • (2001) J Clin Periodontol , vol.28 , pp. 168-174
    • Arweiler, N.B.1    Netuschil, L.2    Reich, E.3
  • 20
    • 0023866553 scopus 로고
    • Side-effects and patient acceptance of 0.2% versus 0.1% chlorhexidine used as post-operative prophylactic mouthwash
    • Hepso HU, Björnland T, Skoglund LA. Side-effects and patient acceptance of 0.2% versus 0.1% chlorhexidine used as post-operative prophylactic mouthwash. Int J Oral Maxillofac Surg 1988;17:17-20.
    • (1988) Int J Oral Maxillofac Surg , vol.17 , pp. 17-20
    • Hepso, H.U.1    Björnland, T.2    Skoglund, L.A.3
  • 21
    • 0032109666 scopus 로고    scopus 로고
    • The effectiveness and side effects of 0.1% and 0.2% chlorhexidine mouthrinses: A clinical study
    • Ernst CP, Prockl K, Willershausen B. The effectiveness and side effects of 0.1% and 0.2% chlorhexidine mouthrinses: A clinical study. Quintessence Int 1998; 29:443-448.
    • (1998) Quintessence Int , vol.29 , pp. 443-448
    • Ernst, C.P.1    Prockl, K.2    Willershausen, B.3
  • 23
    • 0014155768 scopus 로고
    • The gingival index, the plaque index and the retention index system
    • Löe H. The gingival index, the plaque index and the retention index system. J Periodontol 1967;38:610-616.
    • (1967) J Periodontol , vol.38 , pp. 610-616
    • Löe, H.1
  • 24
    • 0024466196 scopus 로고
    • Interaction between chlorhexidine digluconate and sodium laurysulfate in vivo
    • Barkvoll P. Interaction between chlorhexidine digluconate and sodium laurysulfate in vivo. J Clin Periodontol 1989;16:593-595.
    • (1989) J Clin Periodontol , vol.16 , pp. 593-595
    • Barkvoll, P.1
  • 25
    • 0024381872 scopus 로고
    • Studies of the effect of toothpaste rinses on plaque regrowth. 1. Influence of surfactants on chlorhexidine efficiency
    • Addy M, Jenkins S, Newcombe R. Studies of the effect of toothpaste rinses on plaque regrowth. 1. Influence of surfactants on chlorhexidine efficiency. J Clin Periodontol 1989;16:380-384.
    • (1989) J Clin Periodontol , vol.16 , pp. 380-384
    • Addy, M.1    Jenkins, S.2    Newcombe, R.3
  • 26
    • 0031252529 scopus 로고    scopus 로고
    • A short-term clinical study design to investigate the chemical plaque inhibitory properties of mouthrinse when used as adjuncts to toothpastes: Applied to chlorhexidine
    • Owens J, Addy M, Faulkner J, Lockwood C, Adair R. A short-term clinical study design to investigate the chemical plaque inhibitory properties of mouthrinse when used as adjuncts to toothpastes: Applied to chlorhexidine. J Clin Periodontol 1997;24:732-737.
    • (1997) J Clin Periodontol , vol.24 , pp. 732-737
    • Owens, J.1    Addy, M.2    Faulkner, J.3    Lockwood, C.4    Adair, R.5
  • 27
    • 0035219641 scopus 로고    scopus 로고
    • The effect of toothpaste on the propensity of chlorhexidine and cetyl pyridinium chloride to produce staining in vitro: A possible predictor of inactivation
    • Sheen S, Owens J, Addy M. The effect of toothpaste on the propensity of chlorhexidine and cetyl pyridinium chloride to produce staining in vitro: A possible predictor of inactivation. J Clin Periodontol 2001; 28:46-51.
    • (2001) J Clin Periodontol , vol.28 , pp. 46-51
    • Sheen, S.1    Owens, J.2    Addy, M.3
  • 28
    • 0025781195 scopus 로고
    • Mouthwash use and oral conditions in the risk of oral and pharyngeal cancer
    • Winn DM, Blot WJ, McLaughlin JK, et al. Mouthwash use and oral conditions in the risk of oral and pharyngeal cancer. Cancer Res 1991;51:3044-3047.
    • (1991) Cancer Res , vol.51 , pp. 3044-3047
    • Winn, D.M.1    Blot, W.J.2    McLaughlin, J.K.3
  • 29
    • 0029831555 scopus 로고    scopus 로고
    • Alcohol-containing mouthwashes and oropharyngeal cancer: A spurious association due to underascertainment of confounders?
    • Shapiro S, Castellana JV, Sprafka JM. Alcohol-containing mouthwashes and oropharyngeal cancer: A spurious association due to underascertainment of confounders? Am J Epidemiol 1996;144:1091-1095.
    • (1996) Am J Epidemiol , vol.144 , pp. 1091-1095
    • Shapiro, S.1    Castellana, J.V.2    Sprafka, J.M.3
  • 30
    • 0018771178 scopus 로고
    • Mouthwash and oral cancer: Carcinogen or coincidence?
    • Weaver A, Fleming SM, Smith DB. Mouthwash and oral cancer: Carcinogen or coincidence? J Oral Surg 1979;37:250-253.
    • (1979) J Oral Surg , vol.37 , pp. 250-253
    • Weaver, A.1    Fleming, S.M.2    Smith, D.B.3
  • 31
    • 0038150160 scopus 로고    scopus 로고
    • Differences in antimicrobial activity of four commercial 0.12% chlorhexidine mouthrinse formulations: An in vitro contact test and salivary bacterial counts study
    • Herrera D, Roldan S, Santacruz I, et al. Differences in antimicrobial activity of four commercial 0.12% chlorhexidine mouthrinse formulations: An in vitro contact test and salivary bacterial counts study. J Clin Periodontol 2003;30:307-314.
    • (2003) J Clin Periodontol , vol.30 , pp. 307-314
    • Herrera, D.1    Roldan, S.2    Santacruz, I.3
  • 32
    • 0032177944 scopus 로고    scopus 로고
    • An outbreak of Serratia marcescens infections related to contaminated chlorhexidine
    • Vigeant P, Loo VG, Bertrand C, et al. An outbreak of Serratia marcescens infections related to contaminated chlorhexidine. Infect Control Hosp Epidemiol 1998;19:791-794.
    • (1998) Infect Control Hosp Epidemiol , vol.19 , pp. 791-794
    • Vigeant, P.1    Loo, V.G.2    Bertrand, C.3
  • 33
    • 0036366327 scopus 로고    scopus 로고
    • Evaluation of the safety and efficacy of over-the-counter oral hygiene products for the reduction and control of plaque and gingivitis
    • Wu CD, Savitt ED. Evaluation of the safety and efficacy of over-the-counter oral hygiene products for the reduction and control of plaque and gingivitis. Periodontol 2000 2002;28:91-105.
    • (2002) Periodontol 2000 , vol.28 , pp. 91-105
    • Wu, C.D.1    Savitt, E.D.2
  • 34
    • 2142825173 scopus 로고    scopus 로고
    • A randomized clinical trial on the short-term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care
    • Santos S, Herrera D, Lopez E, et al. A randomized clinical trial on the short-term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care. J Clin Periodontol 2004;31:45-51.
    • (2004) J Clin Periodontol , vol.31 , pp. 45-51
    • Santos, S.1    Herrera, D.2    Lopez, E.3
  • 35
    • 0031241765 scopus 로고    scopus 로고
    • Chlorhexidine: Is it still the gold standard?
    • Jones CG. Chlorhexidine: Is it still the gold standard? Periodontol 2000 1997;15:55-62.
    • (1997) Periodontol 2000 , vol.15 , pp. 55-62
    • Jones, C.G.1
  • 38
    • 0040372346 scopus 로고
    • The design of trials to test the efficacy of plaque control agents for periodontal disease in humans
    • Robertson PB, Armitage GA, Buchanan SA, Taggart EJ. The design of trials to test the efficacy of plaque control agents for periodontal disease in humans. J Dent Res 1989;68:1667-1671.
    • (1989) J Dent Res , vol.68 , pp. 1667-1671
    • Robertson, P.B.1    Armitage, G.A.2    Buchanan, S.A.3    Taggart, E.J.4
  • 39
    • 0030114981 scopus 로고    scopus 로고
    • Clinical assessment of bad breath: Current concepts
    • Rosenberg M. Clinical assessment of bad breath: Current concepts. J Am Dent Assoc 1996;127:475-482.
    • (1996) J Am Dent Assoc , vol.127 , pp. 475-482
    • Rosenberg, M.1
  • 40
    • 0036738967 scopus 로고    scopus 로고
    • Evaluation of non-surgical periodontal treatment using 2 time intervals
    • Eren KS, Gürgan CA, Bostanci HS. Evaluation of non-surgical periodontal treatment using 2 time intervals. J Periodontol 2002;73:1015-1019.
    • (2002) J Periodontol , vol.73 , pp. 1015-1019
    • Eren, K.S.1    Gürgan, C.A.2    Bostanci, H.S.3
  • 42
    • 0016341140 scopus 로고
    • Chlorhexidine in dental practice
    • Gjermo P. Chlorhexidine in dental practice. J Clin Periodontol 1974;1:143-152.
    • (1974) J Clin Periodontol , vol.1 , pp. 143-152
    • Gjermo, P.1
  • 43
    • 0020318187 scopus 로고
    • Effect of chlorhexidine mouthrinses on concentration of IgA in expectorates
    • Öydna J, Gjermo P. Effect of chlorhexidine mouthrinses on concentration of IgA in expectorates. Scand J Dent Res 1982;18:189-192.
    • (1982) Scand J Dent Res , vol.18 , pp. 189-192
    • Öydna, J.1    Gjermo, P.2
  • 44
    • 0034823101 scopus 로고    scopus 로고
    • Effects of chlorhexidine on human taste perception
    • Frank ME, Gent JF, Hettinger TP. Effects of chlorhexidine on human taste perception. Physiol Behav 2001; 74:85-99.
    • (2001) Physiol Behav , vol.74 , pp. 85-99
    • Frank, M.E.1    Gent, J.F.2    Hettinger, T.P.3
  • 45
    • 0024791576 scopus 로고
    • Chlorhexidine and related compounds
    • Gjermo P. Chlorhexidine and related compounds. J Dent Res 1989;68:1602-1608.
    • (1989) J Dent Res , vol.68 , pp. 1602-1608
    • Gjermo, P.1
  • 46
    • 0038548553 scopus 로고    scopus 로고
    • Improvement of taste sensitivity of the nursed elderly by oral care
    • Ohno T, Uematsu H, Nozaki S, Sugimoto K. Improvement of taste sensitivity of the nursed elderly by oral care. J Med Dent Sci 2003;50:101-107.
    • (2003) J Med Dent Sci , vol.50 , pp. 101-107
    • Ohno, T.1    Uematsu, H.2    Nozaki, S.3    Sugimoto, K.4
  • 47
    • 0001303785 scopus 로고
    • Mechanisms of stain formation on teeth, in particular associated with metal ions and antiseptics
    • Addy M, Moran J. Mechanisms of stain formation on teeth, in particular associated with metal ions and antiseptics. Adv Dent Res 1995;9:450-456.
    • (1995) Adv Dent Res , vol.9 , pp. 450-456
    • Addy, M.1    Moran, J.2
  • 48
    • 0018729653 scopus 로고
    • An in vitro study of the role of dietary factors in the etiology of tooth staining associated with the use of chlorhexidine
    • Addy M, Prayitno S, Taylo L, Cadogan S. An in vitro study of the role of dietary factors in the etiology of tooth staining associated with the use of chlorhexidine. J Periodontal Res 1979;14:403-410.
    • (1979) J Periodontal Res , vol.14 , pp. 403-410
    • Addy, M.1    Prayitno, S.2    Taylo, L.3    Cadogan, S.4
  • 49
    • 0018876987 scopus 로고
    • Light microscopic and color-television image analysis of the development of staining on chlorhexidine treated surface
    • Addy M, Praytino SW. Light microscopic and color-television image analysis of the development of staining on chlorhexidine treated surface. J Periodontol 1980;51:39-43.
    • (1980) J Periodontol , vol.51 , pp. 39-43
    • Addy, M.1    Praytino, S.W.2
  • 50
    • 0022431272 scopus 로고
    • Extrinsic tooth discoloration by metals and chlorhexidine. II. Clinical staining produced by chlorhexidine, iron and tea
    • Addy M, Moran J. Extrinsic tooth discoloration by metals and chlorhexidine. II. Clinical staining produced by chlorhexidine, iron and tea. Br Dent J 1985;159:331-334.
    • (1985) Br Dent J , vol.159 , pp. 331-334
    • Addy, M.1    Moran, J.2
  • 52
    • 0021875660 scopus 로고
    • Chemical plaque control and extrinsic tooth discolouration. A review of possible mechanisms
    • Eriksen HM, Nordbo H, Kantanen H, Ellingsen J. Chemical plaque control and extrinsic tooth discolouration. A review of possible mechanisms. J Clin Periodontol 1985;12:345-350.
    • (1985) J Clin Periodontol , vol.12 , pp. 345-350
    • Eriksen, H.M.1    Nordbo, H.2    Kantanen, H.3    Ellingsen, J.4
  • 53
    • 0021378652 scopus 로고
    • Auger electron spectroscopy of iron in dental pellicle from stainers and non-stainers
    • Nordbö H, Skjörland KK, Eriksen HM. Auger electron spectroscopy of iron in dental pellicle from stainers and non-stainers. Acta Odontol Scand 1984;42:37-40.
    • (1984) Acta Odontol Scand , vol.42 , pp. 37-40
    • Nordbö, H.1    Skjörland, K.K.2    Eriksen, H.M.3
  • 54
    • 0026090676 scopus 로고
    • The use of an oxidising mouthwash to reduce staining associated with chlorhexidine. Studies in vitro and in vivo
    • Addy M, Al-Arrayed F, Moran J. The use of an oxidising mouthwash to reduce staining associated with chlorhexidine. Studies in vitro and in vivo. J Clin Periodontol 1991;18:267-271.
    • (1991) J Clin Periodontol , vol.18 , pp. 267-271
    • Addy, M.1    Al-Arrayed, F.2    Moran, J.3
  • 56
    • 84985801148 scopus 로고
    • Iron staining of the acquired enamel pellicle after exposure to tannic acid or chlorhexidine: Preliminary report
    • Nordbö H, Eriksen HM, Rölla G, Attramadal A, Solheim H. Iron staining of the acquired enamel pellicle after exposure to tannic acid or chlorhexidine: Preliminary report. Scand Dent Res 1982;90:117-123.
    • (1982) Scand Dent Res , vol.90 , pp. 117-123
    • Nordbö, H.1    Eriksen, H.M.2    Rölla, G.3    Attramadal, A.4    Solheim, H.5
  • 57
    • 0019267987 scopus 로고
    • Chemical plaque control and extrinsic discoloration of teeth
    • Solheim H, Eriksen HM, Nordbö H. Chemical plaque control and extrinsic discoloration of teeth. Acta Odontol Scand 1980;38:303-309.
    • (1980) Acta Odontol Scand , vol.38 , pp. 303-309
    • Solheim, H.1    Eriksen, H.M.2    Nordbö, H.3
  • 58
    • 3142552642 scopus 로고    scopus 로고
    • Impact of tongue cleansers on microbial load and taste
    • Quirynen M, Avontroodt P, Soers C, et al. Impact of tongue cleansers on microbial load and taste. J Clin Periodontol 2004;31:506-510.
    • (2004) J Clin Periodontol , vol.31 , pp. 506-510
    • Quirynen, M.1    Avontroodt, P.2    Soers, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.