Effects of peripubertal exposure to triphenyltin on female sexual development of the rat

Toxicology

Volumn 222, Issue 1-2, 2006, Pages 17-24

  Grote, Konstanze ^a   Andrade, Anderson J M ^a   Grande, Simone Wichert ^a   Kuriyama, Sergio N ^a   Talsness, Chris E ^a   Appel, Klaus E ^b   Chahoud, Ibrahim ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Aromatase; Endocrine disruption; Female; Puberty; Reproduction; Triphenyltin chloride

Indexed keywords

AROMATASE; STEROID HORMONE; TRIPHENYLTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ESTRUS; FEMALE; HORMONE DETERMINATION; NONHUMAN; ORGAN WEIGHT; OVARY; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PUBERTY; RAT; SEXUAL DEVELOPMENT; VAGINA;

ANIMALS; AROMATASE; BIOLOGICAL ASSAY; BRAIN; ENDOCRINE DISRUPTORS; ESTRADIOL; FEMALE; FUNGICIDES, INDUSTRIAL; ORGAN SIZE; ORGANOTIN COMPOUNDS; OVARY; PROGESTERONE; RATS; RATS, WISTAR; SEXUAL DEVELOPMENT; VAGINA;

ANIMALIA; MAMMALIA; RATTUS NORVEGICUS; RODENTIA;

EID: 33646266481     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2006.01.008     Document Type: Article

References (39)

1. Adeeko A., Li D., Forsyth D.S., Casey V., Cooke G.M., Barthelemy J., Cyr D.G., Trasler J.M., Robaire B., and Hales B. Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcome. Toxicol. Sci. 74 (2003) 407-415
2. Amateau S.K., Alt J.J., Stamps C.L., and McCarthy M.M. Brain estradiol content in newborn rats: sex differences, regional heterogeneity, and possible de novo synthesis by the female telencephalon. Endocrinology 145 (2004) 2906-2917
3. Appel K.E. Organotin compounds: toxicokinetic aspects. Drug Metab. Rev. 36 (2004) 763-786
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
5. Cooke G.M. Effects of organotins on human aromatase activity in vitro. Toxicol. Lett. 126 (2002) 121-130
6. Doering D.D., Steckelbroeck S., Doering T., and Klingmüller D. Effects of butyltins on human 5α-reductase type 1 and type 2 activity. Steroids 67 (2002) 859-867
7. EDSTAC, 1998. Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) Final Report, August 1998. US Environmental Protection Agency, Internet access.
8. Ema M., Miyawaki E., and Kawashima K. Suppression of uterine decidualization as a cause of implantation failure induced by triphenyltin chloride in rats. Arch. Toxicol. 73 (1999) 175-179
9. Ema M., and Miyawaki E. Suppression of uterine decidualization correlated with reduction in serum progesterone levels as a cause of preimplantation embryonic loss induced by diphenyltin in rats. Reprod. Toxicol. 16 (2002) 309-317
10. Gibbs P.E., Bryan G.W., and Pascoe P.L. TBT-induced imposex in the dogwhelk Nucella lapillus: geographical uniformity of the response and effects. Mar. Environ. Res. 32 (1991) 79-87
11. Gibbs P.E., Pascoe P.L., and Bryan G.W. Tributyltin-induced imposex in stenoglossan gastropods: pathological effects on the female reproductive system. Comp. Biochem. Physiol. 100C (1991) 231-235
12. Goldman J.M., Laws S.C., Balchak S.K., Cooper R.L., and Kavlock R.J. Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid function in the female rat. A focus on the EDSTAC recommendations. Crit. Rev. Toxicol. 30 (2000) 135-196
13. Golub M.S., and Doherty J.D. Triphenyltin as a potential human endocrine disruptor. J. Toxicol. Environ. Health 7 (2004) 281-295
14. Grote K., Stahlschmidt B., Talsness C.E., Gericke C., Appel K.E., and Chahoud I. Effects of organotin compounds on pubertal male rats. Toxicology 202 (2004) 145-158
15. Hany J., Lilienthal H., Sarasin A., Roth-Harer A., Fastabend A., Dunemann L., Lichtensteiger W., and Winneke G. Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behavior. Toxicol. Appl. Pharmacol. 158 (1999) 231-243
16. Harazono A., and Ema M. Suppression of decidual cell response induced by dibutyltin dichloride in pseudopregnant rats: as a cause of early embryonic loss. Reprod. Toxicol. 17 (2003) 393-399
17. Heidrich D.D., Steckelbroeck S., and Klingmüller D. Inhibition of human cytochrome P450 aromatase activity by butyltins. Steroids 66 (2001) 763-769
18. Hirose A., Takagi A., Nishimura T., Kanno J., and Ema M. Review of reproductive and developmental toxicity induced by organotins in aquatic organisms and experimental animals. Organohalogen Compd. 66 (2004) 3042-3047
19. IPCS, 1990. Tributyl Compounds. Environmental Health Criteria 116, World Health Organization, Geneva.
20. Kannan K., and Falandysz J. Butyltin residues in sediment, fish, fish-eating birds, harbour porpoise and human tissues from the Polish coast of the Baltic Sea. Mar. Poll. Bull. 34 (1997) 203-207
21. Kannan K., Senthilukumar K., and Giesy J.P. Occurence of butyltin compounds in human blood. Environ. Sci. Technol. 33 (1999) 1776-1779
22. Lephart E.D., Simpson E.R., McPhaul M.J., Kilgore M.W., Wilson J.D., and Ojeda S.R. Brain aromatase cytochrome P-450 messenger RNA levels and enzyme activity during prenatal and perinatal development in the rat. Mol. Brain Res. 16 (1992) 187-192
23. Lo S., Allera A., Albers P., Heimbrecht J., Jantzen E., Klingmüller D., and Steckelbroeck S. Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism. J. Steroid Biochem. Mol. Biol. 84 (2003) 569-576
24. Matthiessen P., and Gibbs P. Critical appraisal of the evidence for tributyl-mediated endocrine disruption in mollusks. Environ. Toxicol. Chem. 17 (1998) 37-43
25. Nakanishi T., Kohroki J., Suzuki S., Ishizaki J., Hiromori Y., Takasuga S., Itoh N., Watanabe Y., Utoguchi N., and Tanaka K. Trialkyltin compounds enhance human CG secretion and aromatase activity in human placental choriocarcinome cells. J. Clin. Endocrinol. Metab. 87 (2002) 2830-2837
26. Oehlmann J., Fioroni P., Stroben E., and Markert B. Tributyltin (TBT) effects on Ocinebrina aciculata (Gastropoda: Muricida): imposex development, sterilization, sex change and population decline. Sci. Total Environ. 188 (1996) 205-223
27. Ogata R., Omura M., Shimasaki Y., Kubo K., Oshima Y., Aou S., and Inoue N. Two-generation reproductive toxicity study of tributyltin chloride in female rats. J. Toxicol. Environ. Health, Part A 63 (2001) 127-144
28. Ronis M.J.J., and Mason A.Z. The metabolism of testosterone by the periwinkle (Littorina littorea) in vitro and in vivo: effects of tributyltin. Mar. Environ. Res. 42 (1996) 161-166
29. Roselli C.E. Subcellular localization and kinetic properties of aromatase activity in rat brain. J. Steroid Biochem. Mol. Biol. 52 (1995) 469-477
30. Saitoh M., Yanase T., Morinaga H., Tanabe M., Mu Y.-M., Nishi Y., Nomura M., Okabe T., Goto K., Takayanagi R., and Nawata H. Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN. Biochem. Biophys. Res. Commun. 289 (2001) 198-204
31. Sanderson J.T., Boerma J., Lansbergen G.W.A., and van den Berg M. Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl. Pharmacol. 182 (2002) 44-54
32. Snoeij N.J., van Iersel A.A., Penninks A.H., and Seinen W. Toxicity of triorganotin compounds: comparative in vivo studies with a series of trialkyltin compounds and triphenyltin chloride in male trats. Toxicol. Appl. Pharmacol. 81 (1985) 274-286
33. Snoeij N.J., van Iersel A.A., Penninks A.H., and Seinen W. Triorganotin-induced cytotoxicity to rat thymus, bone marrow and red blood cells as determined by several in vitro assays. Toxicology 39 (1986) 71-83
34. Takahashi S., Mukai H., Tanabe S., Sakayama K., Miyazaki T., and Masuno H. Butyltin residues in livers of humans and wild terrestrial mammals and in plastic products. Environ. Pollut. 106 (1999) 213-218
35. Tian Z.Z., Zhao H., and Chen B.Y. Decreased hypothalamic aromatization in female rats of true precocious puberty. Neurosci. Lett. 366 (2004) 92-96
36. Tryphonas H., Cooke G., Caldwell D., Bondy G., Parenteau M., Hayward S., and Pulido O. Oral (gavage), in utero and post-natal exposure of Sprague-Dawley rats to low doses of tributyltin chloride. Part II: effects on the immune system. Food Chem. Toxicol. 42 (2004) 221-235
37. Tsuda T., Inoue T., Kojima M., and Aoki S. Daily intakes of tributyltin and triphenyltin compounds from meals. JAOAC Int. 78 (1995) 941-943
38. Vos J.G., De Klerk A., Krajnc E.I., Van Loveren H., and Rozing J. Immunotoxicity of bis(tributyltin) oxide in the rat: effect on the thymus-dependent immunity and on nonspecific resistance following long-term exposure in young versus aged rats. Toxicol. Appl. Pharmacol. 105 (1990) 144-155
39. Wester P.W., Krajnc E.I., van Leeuwen F.X., Loeber J.G., van der Heijden C.A., Vaessen H.A., and Helleman P.W. Chronic toxicity and carcinogenicity of bis(tri-n-butyltin) oxide (TBTO) in the rat. Food Chem. Toxicol. 28 (1990) 179-196