Immunostimulants revisited: Focus on the pharmacology of Ribomunyl®

BioDrugs

Volumn 20, Issue 2, 2006, Pages 81-84

  Portalès, Pierre ^a   Clot, Jacques ^a  

^a HÔPITAL SAINT ELOI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN A; IMMUNOSTIMULATING AGENT; OUTER MEMBRANE PROTEIN A; PROTEOGLYCAN; RIBOMUNYL; TOLL LIKE RECEPTOR;

B LYMPHOCYTE ACTIVATION; CELL ADHESION; CELL DIFFERENTIATION; CELL MATURATION; CLINICAL TRIAL; DENDRITIC CELL; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG POTENCY; EAR INFECTION; FRANCE; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; INTERFERON PRODUCTION; KLEBSIELLA PNEUMONIAE; NATURAL KILLER CELL; NONHUMAN; NOSE INFECTION; OTITIS MEDIA; PHAGOCYTOSIS; PHARYNGITIS; PRIORITY JOURNAL; RECURRENT DISEASE; REGULATORY MECHANISM; RESPIRATORY TRACT INFECTION; REVIEW; RHINOPHARYNGITIS; RIBOSOME; SINUSITIS; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

EID: 33646265735     PISSN: 11738804     EISSN: 11738804     Source Type: Journal    
DOI: 10.2165/00063030-200620020-00002     Document Type: Review

References (41)

1. Hoebe K, Janssen E, Beutler B. The interface between innate and adaptative immunity. Nat Immunol 2004; 5: 971-4
2. Rossi M, Young JW. Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptative immunity. J Immunol 2005; 175: 1373-81
3. Clot J. Pharmacology of ribosomal immunotherapy. Drugs 1997; 54 Suppl. 1: 33-6
4. Dussourd d'Hinterland L, Normier G, Durand I. Ribosomal vaccines: preparation of subcellular fractions. Arzneimittel Forschung 1980; 8: 126-32
5. Mechnikov I. Nobel lecture, 11 December 1908: on the present state of the question of immunity in infectious diseases. Nobleprize.org [online]. Available from URL: http://www.nobel.se/medicine/laureates/1908/mechnikov-lecture.html [Accessed 2006 Mar 20]
6. Medzhitov R, Janeway CA. Decoding the patterns of self and nonself by the innate immune system. Science 2002; 296: 298-300
7. Bellanti JA, Olivieri D, Seranno E. Ribosomal immunostimulation: assessment of studies evaluating its clinical relevance in the prevention of upper and lower respiratory tract infections in children and adults. BioDrugs 2003; 17 (5): 355-67
8. Boyle P, Bellanti JA, Robertson C. Meta-analysis of published clinical trials of a ribosomal vaccine (Ribomunyl®) in prevention of respiratory infections. BioDrugs 2000; 14: 389-408
9. Galioto GB, Galioto P, Mevio E, et al. Efficacy and tolerability of Immucytal® in the prevention and treatment of respiratory tract infections in adults: a randomized, placebo-controlled, double-blind study. Int J Immunother 2001; 17: 31-40
10. Gramiccioni E, Girbino G, Pelucco D. Efficacy and tolerability of Immucytal® in the prevention of upper respiratory tract infections: a randomized, placebo-controlled, double-blind study. J Clin Res 2001; 4: 53-63
11. Serrano E, Demanez JP, Morgon A, et al. Effectiveness of ribosomal fractions of Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and the membrane fraction of Kp (Ribomunyl) in the prevention of clinical recurrences of infectious rhinitis: results of a multicenter double-blind placebo-controlled study. Eur Arch Otorhinolaryngol 1997; 254: 372-5
12. Giovannini M, Fiocchi A, Sala M, et al. Immucytal in the prevention and treatment of recurrent upper respiratory tract infections in children: a randomized, placebo-controlled, double-blind study. Int J Immunother 2000; 16: 67-75
13. Mora R, Barbieri M, Passali G, et al. A preventive measure for otitis media in children with upper respiratory tract infections. Int J Pediatr Otorhinolaryngol 2002; 63: 111-8
14. Kerneis S, Bogdanova A, Kraehenbuhl JP, et al. Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 1997; 277: 949-52
15. Kraehenbuhl JP, Neutra MR. Epithelial M cells: differentiation and function. Annu Rev Cell Dev Biol 2000; 16: 301-32
16. Caliot E, Libon C, Kerneis S, et al. Translocation of ribosomal immunostimulant through an in vitro-reconstituted digestive barrier containing M-like cells. Scand J Immunol 2000; 52: 588-94
17. Brandtzaeg P, Farstad IN, Haraldsen G. Regional specialization in the mucosal immune system: primed cells do not always home along the same track. Immunol Today 1999; 20: 267-77
18. Roques C, Frayret MN, Luc J, et al. Effect of an in vivo immunostimulant treatment on PMN functions: interaction with antibiotics in vitro. Int J Immunopharmacol 1991; 13: 1051-7
19. Roques C, Frayret MN, Luc J, et al. Immunostimulant effects on granulocyte functions during an acute respiratory infection. Dev Biol Stand 1992; 77: 183-7
20. Hbabi L, Roques C, Michel G, et al. In vitro stimulation of polymorphonuclear cell adhesion by Ribomunyl and antibiotic + Ribomunyl combinations: effects on CD18, CD35 and CD16 expression. Int J Immunopharmacol 1993; 15: 163-73
21. Hbabi-Haddioui L, Roques C. Inhibition of Streptococcus pneumoniae adhesion by specific salivary IgA after oral immunisation with a ribosomal immunostimulant. Drugs 1997; 54: 29-32
22. Boccaccio C, Jacod S, Kaiser A, et al. Identification of a clinical-grade maturation factor for dendritic cells. J Immunother 2002; 25: 88-96
23. Jongmans W, Tiemessen DM, van Vlodrop IJ, et al. Th1-polarizing capacity of clinical-grade dendritic cells triggered by Ribomunyl but is compromised by PGE2. J Immunother 2005; 28: 480-7
24. Rauly I, Goetsch L, Haeuw JF, et al. Carriers properties of a protein derived from outer membrane protein A of Klebsiella pneumoniae. Infect Immun 1999; 67: 5547-51
25. Jeannin P, Renno T, Goetsch L, et al. OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway. Nat Immunol 2000; 1: 502-9
26. Goetsch L, Gonzalez A, Plotnicky-Gilquin H, et al. Targeting of nasal mucosa-associated antigen-presenting cells in vivo with an outer membrane protein A derived from Klebsiella pneumoniae. Infect Immun 2001; 69: 6434-44
27. Jeannin P, Magistrelli G, Goetsch L, et al. Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen presenting cells-impact on vaccine strategies. Vaccine 2002; 20: A23-7
28. Jeannin P, Bottazzi B, Sironi M, et al. Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors. Immunity 2005; 22: 551-60
29. Sironi M, Sica A, Riganti F, et al. Interleukin-6 gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae. Int J Immunopharmacol 1990; 12: 397-402
30. Luini W, De Rossi M, Licciardello L, et al. Chemotactic cytokine gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae. Int J Immunopharmacol 1991; 13: 631-7
31. Chalifour A, Jeannin P, Gauchat JF, et al. Direct bacterial protein PAMPs recognition by human NK cells involves TLRs and triggers α-defensin production. Blood 2004; 104: 1778-83
32. Hertzog PJ, O'Neil LA, Hamilton JA. The interferon in TLR signalling: more than just antiviral. Trends Immunol 2003; 24: 534-9
33. Zanin C, Béné MC, Perruchet AM, et al. Bacterial crude extracts or ribosomes are recognized similarly by peripheral and mucosal B cells. FEMS Immunol Med Microbiol 1994; 10: 11-8
34. Béné MC, Kahl L, Perruchet AM, et al. Bacterial lysates and ribosomes inducers of specific immune responses: a comparative study. Scand J Immunol 1993; 38: 496-8
35. Faure GC, Béné MC, Simon C, et al. Increase in specific antibody-forming cells in human tonsils after oral stimulation with D-53, a ribosomal vaccine. Int J Immunopharmacol 1990; 12: 315-20
36. Zanin C, Perrin P, Béné MC, et al. Antibody-producing cells in peripheral blood and tonsils after oral treatment of children with bacterial ribosomes. Int J Immunopharmacol 1994; 16: 497-505
37. Béné MC, Zanin C, Perrin P, et al. Specific antibody-producing cells in humans after oral immunization with a ribosomal vaccine Ribomunyl. Adv Exp Med Biol 1995; 371B: 1563-6
38. Kolopp-Sarda MN, Béné MC, Allaire JM, et al. Kinetics of specific salivary IgA responses in man after oral challenge by a ribosomal immunostimulant. Int J Immunopharmacol 1997; 19: 181-6
39. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145-73
40. Moine V, Corvaia N, Libon C. Inhibition of Immunoglobulin E synthesis by a membrane fraction from Klebsiella pneumoniae (FMKp). Int J Immunother 2002; 18: 73-81
41. Bystron J, Hermanova Z, Szotkovska J, et al. Effect of ribosomal immunotherapy on the clinical condition and plasma levels of cytokines IL-4, IL-5, IL-12 and IFN-γ and total IgE in patients with seasonal allergy during the pollen season. Clin Drug Invest 2004; 24: 761-4