Biosynthesis of imipramine glucuronide and characterization of imipramine glucuronidation catalyzed by recombinant UGT1A4

Acta Pharmacologica Sinica

Volumn 27, Issue 5, 2006, Pages 623-628

  Qian, Ming Rong ^a   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Baculovirus; Glucuronide; Imipramine; Solid phase extraction; Uridine 5 diphosphoglucuronosyltransferase 1A4

Indexed keywords

4 NITROPHENOL; DRUG METABOLITE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; IMIPRAMINE; IMIPRAMINE GLUCURONIDE; RECOMBINANT ENZYME; RECOMBINANT GLUCURONOSYLTRANSFERASE 1A4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; BIOSYNTHESIS; CATALYSIS; CELL FREE SYSTEM; CELL STRAIN; CELL STRAIN SF9; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DETERMINATION; DRUG GLUCURONIDATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME SUBSTRATE; IN VITRO STUDY; INSECT CELL; NONHUMAN; PHARMACOKINETICS; PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION;

ANIMALS; BACULOVIRIDAE; BIOTRANSFORMATION; CELLS, CULTURED; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; IMIPRAMINE; KINETICS; RECOMBINANT PROTEINS; SPODOPTERA;

EID: 33646234012     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00314.x     Document Type: Article

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