Evaluation of microbiological contamination of crude herbal drugs;Avaliação da contaminação microbiana em drogas vegetais

Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

Volumn 41, Issue 4, 2005, Pages 491-497

  Bugno, Adriana ^a   Buzzo, Adriana Aparecida ^a   Nakamura, Cristina Terumi ^a   Pereira, Tatiana Caldas ^a   De Matos, Dulcilena ^a   De Pinto, Terezinha Jesus Andreoli ^b  

^a INSTITUTO ADOLFO LUTZ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Herbal drugs; Microbiological contamination; Quality control

Indexed keywords

HERBACEOUS AGENT;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; EDUCATION; HERB; MEDICAL LITERATURE; MICROBIAL CONTAMINATION; NONHUMAN; PUBLIC HEALTH; QUALITY CONTROL;

EID: 33646229293     PISSN: 15169332     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1516-93322005000400012     Document Type: Article

References (40)

1. ABOU-ARAB, A. A. K.; KAWTHER, M. S.; EL TANTAWY, M. E.; BADEAA, R. I.; KHAYRIA, N. Quantity estimation of some contaminants in commonly used medicinal plants in the Egyptian market. Food Chem., Barking, v.67, p.357-363, 1999.
2. ABU-IRMAILEH, B. E.; AFIFI, F. U. Herbal medicine in Jordan with special emphasis on commonly used herbs. J. Ethnopharmacol., Lausanne, v.89, p.193-197, 2003.
3. ALEXANDER, R. G.; WILSON, D. A.; DAVIDSON, A. G. Medicines control agency investigation of the microbial quality of herbal products. Pharm. J. Verwoodburg, v.259, p.259-261, 1997.
4. AZIZ, N. H.; YOUSSEF, Y. A.; EL-FOULY, M. Z.; MOUSSA, L. A. Contamination of some common medicinal plant samples and spices by fungi and their mycotoxins. Bot. Bull. Acad. Sinica, Cairo, v.39, n.4, p.279-285, 1998.
5. BENT, S.; KO, R. Commonly used herbal medicines in the United States: a review. Am. J. Med., New York, v.116, p.478-485, 2004.
6. BERMUDEZ, A. D. M.; LECEA, J. R.; SOUS, F. M.; ESTERAS, T. S. Micoflora de matérias primas. Boll. Chim. Farm., Milano, v.123, p.123-129, 1983.
7. BRASIL. Resolução RDC n° 48, de 16 de março de 2004. Dispõe sobre o registro de medicamentos fitoterápicos. Diário Oficial [da] República Federativa do Brasil, Brasília, DF, 18 mar. 2004. Disponível em: 〈http://www. anvisa.gov.br/legis/resol/2004/48_04rdc.htm〉. Acesso em: 22 mar. 2004.
8. CALIXTO, J. B. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Braz. J. Med. Biol. Res., Ribeirão Preto, v.33, p.179-189, 2000.
9. CAPASSO, F. The medicinal plants in our time. Boll. Chim. Farm., Milano, v.125, n.9, p.322-327, 1986.
10. CHAN, K. Some aspects of toxic contaminants in herbal medicines. Chemosphere, Oxford, v.52, p.1361-1371, 2003.
11. CHOURASIA, H. K. Mycobiota and mycotoxins in herbal drugs of Indian pharmaceutical industries. Mycol. Res., Cambridge, v.99, n.6, p.697-703, 1995.
12. CZECH, E.; KNEIFEL, W.; KOPP, B. Microbiological status of commercially available medicinal herbal drugs - a screening study. Planta Med., Stuttgart, v.67, p.263-269, 2001.
13. DE SMET, P. A. G. M. Health risks of herbal remedies: an update. Clin. Pharmacol Ther., St. Louis, v.76, p.1-17, 2004.
14. EFUNTOYE, M. O. Fungi associated with herbal drug plants during storage. Mycopathologia, Den Haag, v.136, p. 115-118, 1996.
15. EL-KADY, I. A.; EL-MARAGHY, S. S. M.; MOSTAFA, E. Contribution of the mesophilic fungi of different spices in Egypt. Mycopathologia, Den Haag, v.120, p.93-101, 1992.
16. ELSHAFIE, A. E.; AL-LAWATIA, T.; AL-BAHRY, S. Fungi associated with black tea and tea quality in the Sultanate of Oman. Mycopathologia, Den Haag, v.145, p.89-93, 1999.
17. ELSHAFIE, A. E.; AL-RASHDI, T.; AL-BAHRY, S. N.; BAKHEIT, C. S. Fungi and aflatoxins ssociated with spices in the Sultanate of Oman. Mycopathogia, Den Haag, v.155, p.155-160, 2002.
18. ELVIN-LEWIS, M. Should we be concerned about herbal remedies? J. Ethnopharmacol., Clare, v.75, p.141-164, 2001.
19. FARMACOPÉIA Brasileira. 4. ed. São Paulo: Atheneu, 1988, Parte 1. p. V.5.1.6.-1-V.5.1.7.-6.
20. FENNELL, C. W.; LIGHT, M. E.; SPARG, S. G.; STAFFORD, G I.; VAN STADEN, J. Assessing African medicinal plants for efficacy and safety: agricultural and storage practices. J. Ethnopharmacol., Clare, v.95, p.113-121, 2004.
21. FISCHER, D. C. H.; OHARA, M. T.; SAITO, T. Contaminação microbiana em medicamentos fitoterápicos sob a forma sólida. Rev. Farm. Bioquim. Univ. S. Paulo, São Paulo, v.29, p.81-88, 1993.
22. FISCHER, D. C. H.; OHARA, M. T.; SAITO, T. Padrão microbiano em medicamentos não estéreis de uso oral. Rev. Bras. Farmacogn., São Paulo, v.1, p.29-54, 1996.
23. GARCIA, E. S.; SILVA, A. C. P.; GILBERT, B.; CORREA, C. B. V.; CAVALHEIRO, M. V. S.; SANTOS, R. R. E TOMASSINI, T. Biodiversidade: perspectivas e oportunidades tecnologicas. Fitoterápicos. Disponível em: 〈http://www.bdt.org.br/publicações/padct/bio/cap10/Eloi. html〉. Acesso em: 12 fev. 2003.
24. GARRIDO, D.; JODRAL, M.; POZO, R. Mold flora and aflatoxin-producing strains of Aspergillus flavus in spices and herbs. J. Food Prot., Des Moines, v.55, n.6, p.451-452, 1992.
25. GIVEON, S.M.; LIBERMAN, N.; KLANG, S.; KAHAN, E. Are people who use "natural drugs" aware of their potentially harmful side effects and reporting to family physician? Patient Educ. Couns., Princeton, v.53, p.5-11, 2004.
26. HALT, M. Moulds and mycotoxins in herb tea and medicinal plants. Eur. J. Epidemiol., New York, v.14, p.269-274, 1998.
27. KNEIFEL, W.; BERGER, E. Microbiological criteria of random samples of spices and herbs retailed on the Austrian market. J. Food Prot., Des Moines, v.57, n.10, p.893-901, 1994.
28. KOROLKOVAS, A. A riqueza potencial de nossa flora. Rev. Bras. Farmacognosia, São Paulo, v.1, p.1-7, 1996.
29. LUTOMSKI, J.; KEDZIA, B. Mycoflora of crude drugs. Estimation of mould contaminations and their toxicity. Planta Medica, Stuttgart, v.40, p.212-217, 1980.
30. MAHADY, G. B. Global Harmonization of Herbal Health Claims. J. Nutr., Philadelphia, v.131, p.1120S-1123S, 2001.
31. MANDEEL, Q. A. Fungal contamination of some imported spices. Mycopathologia, Den Haag, v.159, p.291-298, 2005
32. MARQUES, L. C. Vigilância de fitoterápicos - I: o caso da arnica. Rev. Bras. Farmacogn., São Paulo, v.1, p.8-19, 1996.
33. MARTINS, H. M.; MARTINS, M. L.; DIAS, M. I.; BERNARDO, F. Evaluation of microbiological quality of medicinal plants used in natural infusions. Int. J. Food Microbiol., Amsterdam, v.68. p.149-153, 2001.
34. PITT, J. I. The genus Penicillium. Sidney, Australia: Academic Press Inc., 1979.
35. RAPPER, K. B.; FENNEL, D.I. The genus Aspergillus. Baltimore: The Williams and Wilkins Company, 1965.
36. RATES, S. M. K. Plants as source of drugs. Toxicon, v.39, p. 603-613, 2001.
37. RHODEHAMEL, E.J.; HARMON, S.M. Bacillus cereus. In: Bacteriological Analytical Manual Online, 2001. FOOD AND DRUGS ADMINISTRATION - Center for Food Safety and Applied Nutrition. Disponivel em: 〈http://www.cfsan.fda.gov/ 〉. Acesso em: 10 Jan. 2003.
38. RIZZO, I.; VEDOYA, G.; MAURUTTO, S.; HAIDUKOWSKI, M.; VARSAVSKY, E. Assessment of toxigenic fungi on Argentinean medicinal herbs. Microbiol. Res., Buenos Aires, v.159, n.2, p.113-120, 2004.
39. SANTOS, P. R. V.; OLIVEIRA, A. C. X.; TOMASSINI, T. C. B. Controle microbiológico de produtos fitoterápicos. Rev. Farm. Bioquim. Univ. S. Paulo, São Paulo, v.31, p.35-38, 1995.
40. THE UNITED States Pharmacopeia. 28. ed. Rockville: United States Pharmacopeial Convention, 2005. 3013 p.