Inhibitory action of Vit C and mannitol on induced cytotoxic effect of glycated protein-metal ion on rat hepatocyte

International Journal of Pharmacology

Volumn 2, Issue 2, 2006, Pages 201-204

  Goodarzi, Mohammad Taghi ^a   Safari, Mohammad Reza ^b   Zal, Fatemeh ^c  

^a HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Ascorbic acid; Glycation; Mannitol; Rat hepatocytes

Indexed keywords

ASCORBIC ACID; GLUCOSE; GLYCOSYLATED ALBUMIN; GLYCOSYLATED PROTEIN; MALONALDEHYDE; MANNITOL; METAL ION; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CELL SUSPENSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; IN VITRO STUDY; LIVER CELL; NONHUMAN; OXIDATIVE STRESS; PROTEIN GLYCOSYLATION; RAT; STATISTICS; WILCOXON SIGNED RANKS TEST;

EID: 33646191435     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2006.201.204     Document Type: Article

References (22)

1. Akhilender, N. K., 2003. Vitamin C in human health and disease is still a mystery? An overview. Nutr. J., 2: 7-17.
2. Cheng, C.J., R.H. Hsieh, H.F. Wang, M.Y. Chin and S.Y. Huang, 2005. Effects of glucose and α-tocopherol on low-density lipoprotein oxidation and glycation. Ann. N.Y. Acad. Sci., 1042: 294-302.
3. Dickinson, P.J., A.L. Carrington, G.S. Frost and A.J. Boulton, 2002 Neurovascular disease, antioxidants and glycation in diabetes. Diabetes Metab. Res. Rev., 18: 260-272.
4. Furth, A.J., 1988. Methods for assaying nonenzymatic glycosylation. Anal. Biochem., 175: 347-360
5. Gutteride, J.U.C. and G.J. Quinlan, 1998. MDA formation from lipid peroxidation in the TBA test: The role of lipid radicals, iron salts and metal chelator. J. Biochem., 5: 293-299.
6. Goodarzi, M.T., M.R. Safari and F. Zal, 2005. Cytotoxic effect of "glycated albumin- transition metal ion" on rat hepatocytes. Iranian Biomed. J. (submitted).
7. Hess, J.R. and T.G. Greenwalt, 2002. Storage of red blood cells: New approaches. Transfus. Med. Rev., 16: 283-295.
8. Kim, H., J.Y. Seo and K.H. Kim, 2002. Effect of mannitol on Helicobacter pylori-induced cyclooxygenase-2 expression in gastric epithelial AGS cells. Pharmacology, 66: 182-189.
9. Knott, H.M., B.E. Brown, M.J. Davies, R.T. Dean, 2003. Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes. Formation of modified and oxidized particles. Eur. J. Biochem., 270: 3572-3582.
10. Lin, J., 1997. Pathophysiology of cataracts: copper ion and peroxidation in diabetics. Jpn. J. Ophtalmol., 41: 130-137.
11. Monnier, V.M., 1990. Non-enzymatic glycosylation: The Maillard reaction and the ageing process. J. Gerontol., 45: B105-111.
12. Meli, M., J. Frey and C. Perier 2003. Native protein glycoxidation and aging. J. Nutr. Health Aging, 7: 263-266.
13. Padayatty, S.J. and M. Levine, 2001. New insights into the physiology and pharmacology of Vitamin C. CMAJ., 164: 353-355.
14. Sajithlal, G.B., P. Chithra and G. Chandrakasan, 1998. The role of metal-catalyzed oxidation in the formation of advanced glycation end products: An in vitro study on collagen. Free Radic. Biol. Med., 28: 265-269.
15. Sigh, R., A. Barden, T. Mort and L. Bellin, 2001. Advanced glycation end-products: A review. Diabetologica, 44: 129-146.
16. Stitt, AW., 2001. Advanced glycation: An important pathological event in diabetic and related ocular disease. Br. J. Ophtalmol., 85: 746-753.
17. Sheetz, M.J. and G.I. King, 2003. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA., 289: 1779-1780.
18. Therond, P., D. Bonefont-Rousselot, Davit-Spraul, M. Conti and A. Legrand 2000. Biomarkers of oxidative stress: An analytical approach. Curr. Opin. Clin. Nutr. Metab. Care, 3: 373-384.
19. Valassar, H. and M.R. Palace, 2003. Glycoxidation: The menace of diabetes and aging. Mt. Sinai. J. Med., 70: 232-241.
20. Wendt, T., N. Tanji, J. Gou and B.I. Hudson, 2003. Glucose, Glycation and RAGE: Implication for amplification of cellular dysfunction in diabetic nephropathy. J. Am. Soc. Nephrol., 14: 1383-1395.
21. Wauteier J.L. and A.M. Schmidt, 2004. Protein glycation: A firm link to endothelial cell dysfunction. Circ. Res., 95: 233-238.
22. Yim, M., B. Yim, H.S. C. Lee, S.O. Kang and P.B. Chock, 2001. Protein glycation: creation of catalytic sites for free radical generation. Ann. N.Y. Acad. Sci., 928: 48-53.