Obesity induced by neonatal monosodium glutamate treatment in spontaneously hypertensive rats: An animal model of multiple risk factors

Hypertension Research

Volumn 21, Issue 1, 1998, Pages 1-6

  Iwase, Masanori ^a,b   Yamamoto, Misao ^a   Iino, Kenzo ^a   Ichikawa, Kojiro ^a   Shinohara, Noriyasu ^a   Yoshinari, Mototaka ^a   Fujishima, Masatoshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Animal model; Atherosclerosis; Diabetes mellitus; Insulin resistance; Syndrome X

Indexed keywords

CHOLESTEROL; DNA; GLUTAMATE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD LEVEL; BLOOD PRESSURE; CAROTID ARTERY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HYPERINSULINEMIA; HYPERLIPIDEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOTHALAMUS; IMPAIRED GLUCOSE TOLERANCE; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLIC DISORDER; NEWBORN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; RAT; RISK FACTOR; SPONTANEOUSLY HYPERTENSIVE RAT; SYNDROME X; VASCULAR DISEASE;

EID: 0031957393     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.21.1     Document Type: Article

References (28)

1. Reaven GM: Role of insulin resistance in human disease. Diabetes 1989; 37: 1595-1607.
2. Stout RW: Experimental atherosclerosis and diabetes mellitus, in Stout RW (ed): Diabetes and atherosclerosis. Netherlands, Kluwer Academic Publishers, 1992, pp 267-291.
3. Björntorp P: Visceral obesity. A civilization syndrome. Obesity Res 1993; 1: 206-222.
4. Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Tokunaga K: Pathophysiology and pathogenesis of visceral fat obesity. Diabetes Res Clin Pract 1994; 24 (Suppl): S111-S116.
5. Stern MP: Diabetes and cardiovascular disease. The common soil hypothesis. Diabetes 1995; 44: 369-374.
6. Godsland IF, Stevenson JC: Insulin resistance: syndrome or tendency? Lancet 1995; 346: 100-103.
7. Davidson MB: Clinical implications of insulin resistance syndromes. Am J Med 1995; 99: 420-426.
8. Wingard DL, Ferrara A, Barrett-Connor EL: Is insulin really a heart disease risk factor? Diabetes Care 1995; 18: 1299-1304.
9. Olney JW: Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 1969; 164: 719-721.
10. Folch J, Lees M, Sloane Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
11. Labarca C, Paigen K: A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 1980; 102: 344-352.
12. Paulson DJ, Tahiliani AG: Cardiovascular abnormalities associated with human and rodent obesity. Life Sci 1992: 51: 1557.
13. Kasiske BL, O'Donnell MP, Keane WF: The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 1992; 19 (Suppl I): I-110-I-115.
14. Yamakawa T, Tanaka S, Tamura K, et al: Wistar fatty rat is obese and spontaneously hypertensive. Hypertension 1995; 25: 146-150.
15. Armstrong ML, Heistad DD: Animal models of atherosclerosis. Atherosclerosis 1990; 85: 15-23.
16. Amy RM, Dolphin PJ, Pederson RA, Russell, JC: Atherogenesis in two strains of obese rats: the fatty Zucker and LA/N-corpulent. Atherosclerosis 1988; 69: 199.
17. Reisin E, Wilson JR, Frohlich ED: Hypertension and obesity in rats with ventromedial-hypothalamic lesions and low salt intake. J Hypertens 1987; 5: 173-178.
18. Weidmann P, Bohlen L, de Courten M: Insulin resistance and hyperinsulinemia in hypertension. J Hypertens 1995; 13 (Suppl): S65-S72.
19. Tsutsu N, Nunoi K, Kodama T, Nomiyama R, Iwase M, Fujishima M: Lack of association between blood pressure and insulin in patients with insulinoma. J Hypertens 1990; 8: 479-481.
20. Iwase M, Nunoi K, Wakisaka M, et al: Blood pressure changes associated with hyperinsulinemia or long-standing diabetes mellitus in spontaneously hypertensive rats. J Diabetes Complications 1990; 4: 184-187.
21. Katayama S, Abe M, Kashiwabara H, Kosegawa I, Ishii J: Evidence against a role of insulin in hypertension in spontaneously hypertensive rats. CS-045 does not lower blood pressure despite improvement of insulin resistance. Hypertension 1994; 23: 1071-1074.
22. Iwase M, Kodama T, Himeno H, et al: Effect of aging on glucose tolerance in spontaneously hypertensive rats. Clin Exp Hypertens 1994; 16: 67-76.
23. Meister B, Ceccatelli S, Hökfelt T, Andén N-E, Andén M, Theodorsson E: Neurotransmitters, neuropeptides and binding sites in the rat mediobasal hypothalamus: effects of monosodium glutamate (MSG) lesions. Exp Brain Res 1989; 76: 343-368.
24. Hall JE: Renal and cardiovascular mechanisms of hypertension in obesity. Hypertension 1994; 23: 381-394.
25. Chobanian AV: Adaptive and maladptive responses of the arterial wall to hypertension. Hypertension 1990; 15: 666-674.
26. De Mey JGR, Daemen MJAP, Boonen HCM, et al: In vivo DNA synthesis is not uniformly increased in arterial smooth muscle of young spontaneously hypertensive rats. J Hypertens 1991; 9: 695-701.
27. Owens GK, Schwartz SM: Alterations in vascular smooth muscle mass in the spontaneously hypertensive rat: role in cellular hypertrophy, hyperploidy and hyperplasia. Circ Res 1982; 51: 280-289.
28. Capron L, Philippe M, Guilmot J-L, Fiessinger J-N, Housset E: Effects of insulin exposure upon the metabolism of rat aortic media. Influence of hydrostatic forces. Arteriosclerosis 1981; 1: 345.