Eberconazole 1% cream is an effective and safe alternative for dermatophytosis treatment: Multicenter, randomized, double-blind, comparative trial with miconazole 2% cream

International Journal of Dermatology

Volumn 45, Issue 5, 2006, Pages 600-604

  Montero, Trinidad Repiso ^a,b,c,d,e,f   López, Sara ^a,b,c,d,e,f   Rodríguez, Carmen ^a,b,c,d,e,f   del Rio, Ruben ^a,b,c,d,e,f   Badell, Anna ^a,b,c,d,e,f   Gratacós, M Rosa ^a,b,c,d,e,f  

^a CAP Sant Andreu   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c HOSPITAL DO MEIXOEIRO   (Spain)

^d CAP Drassanes   (Spain)

^e CAP Cornellà ^*  (Spain)

^f CAP Dr Robert   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EBERCONAZOLE; MICONAZOLE;

ADULT; ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DERMATOMYCOSIS; DESQUAMATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ERADICATION THERAPY; ERYTHEMA; FEMALE; FUNGUS CULTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NONHUMAN; PHASE 3 CLINICAL TRIAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; TINEA CORPORIS; TINEA CRURIS; TINEA PEDIS; TREATMENT OUTCOME;

ADMINISTRATION, CUTANEOUS; ADULT; ANTIFUNGAL AGENTS; CYCLOHEPTANES; DERMATOMYCOSES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMIDAZOLES; MALE; MICONAZOLE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; SPAIN; TREATMENT OUTCOME;

EID: 33646181406     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/j.1365-4632.2006.02841.x     Document Type: Article

References (19)

1. Hay RJ. Fungi and fungal infections of the skin. In: Noble WC, ed. The Skin Microflora and Microbial Skin Disease. Cambridge: Cambridge University Press, 1992: 232-263.
2. Font E, Freixes J, Julve J. Perfil del nuevo antimicótico tópico eberconazol. Rev Iberoam 1995; 12: 16-17.
3. Tomas JM. Inhibition of two imidazole antimycotics, eberconazole and clotrimazole, by different components of Candida albicans serotype b membrane protoplasts. Int J Antimicrob Ther 1993; 3: 61-64.
4. Rabasseda X. Eberconazole nitrate. Drugs Future 1996; 21: 792-793.
5. Carrillo-Muñoz AJ, Pemán J, Gobernado M. Nuevos antifúngicos. Presente y futuro. Rev Esp Quimioterap 1999; 12: 181-204.
6. Rubin AI, Bagheri B, Scher RK. Six novel antimycotics. Am J Clin Dermatol 2002; 3: 71-81.
7. Font E. Actividades complementarias y perfil toxicológico del nuevo antifúngico tópico eberconazol. Farmacol Clin Exp 1993; 161: 26-A.
8. Del Palacio A, Cuétara S, Rodríguez A. Topical treatment of Tinea corporis and Tinea cruris with eberconazole (WAS 2160) cream 1% and 2% a phase II dose finding pilot study. Mycoses 1995; 38: 317-324.
9. Del Palacio A, Ortiz FJ, Pérez A, et al. A double-blind randomized comparative trial: Eberconazole 1% cream versus clotrimazole 1% cream twice daily in Candida and dermatophyte skin infections. Mycoses 2001; 44: 173-180.
10. Brennan B, Leyden JJ. Overview of topical therapy for common superficial fungal infections and the role of new topical agents. J Am Acad Dermatol 1997; 36: S3-S8.
11. Dooms-Goossens A, Matura M, Drieghe J, et al. Contact allergy to imidazoles used as antimycotic agents. Contact Dermatitis 1995; 33: 73-77.
12. Muller FMC. Eberconazole. Curr Opin Anti-Infect Invest Drugs 2000; 2: 416-419.
13. Kalis B, Grosshans E, Binet O, et al. Oxiconazole crème versus kétoconazole crème. Étude prospective, randomisée, en double insu, multicentrique, dans le traitement des dermatophytoses inguinocrurales. Ann Dermatol Venereol 1996; 123: 447-452.
14. Hart R, Bell-Syer SEM, Crawford F, et al. Systematic review of topical treatments for fungal infections of the skin and nails of the feet. Br Med J 1999; 319: 79-82.
15. Alomar A, Videla S, Delgadillo J, et al. Efficacy of flutrimazole 1% dermal cream in dermatomycoses (Report of a Working Group of the Catalan Flutrimazole Study Group). Dermatology 1995; 190: 295-300.
16. Fernández-Torres B, Inza I, Guarro J. In vitro activities of the new antifungal drug eberconazole and three other topical agents against 200 strains of dermatophytes. J Clin Microbiol 2003; 41: 5209-5211.
17. Leenutaphong V, Niumpradit N, Tangwiwat S, et al. Double-blind study of the efficacy of 1 week topical terbinafine cream compared to 4 weeks miconazole cream in patients with Tinea pedis. J Med Assoc Thai 1999; 82: 1006-1010.
18. Ibarra A, Carrera C, Saro G, et al. Las micosis superficiales. Med Int 1995; 25: 65-71.
19. Colomina J, Rodilla F, Giner S, et al. Actualidades terapéuticas en las infecciones por hongos. Farm Clin 1996; 13: 264-273.