The transport of manganese across the blood-brain barrier

NeuroToxicology

Volumn 27, Issue 3, 2006, Pages 311-314

  Aschner, Michael ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Blood brain barrier; Divalent metal transporter 1 (DMT 1); Manganese; Neurotoxicity; Transferrin; Transport

Indexed keywords

MANGANESE; METAL; TRANSFERRIN;

ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; DIFFUSION; ENDOTHELIUM CELL; HUMAN; MACROMOLECULE; MICROENVIRONMENT; NEUROTOXICITY; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; SOLUTE; TIGHT JUNCTION;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; HUMANS; MANGANESE;

MAMMALIA;

EID: 33646171934     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2005.09.002     Document Type: Article

References (28)

1. Aisen P., Aasa R., and Redfield A.G. The chromium, manganese, and cobalt complexes of transferring. J. Bio. Chem. 244 (1969) 4628-4633
2. Archibald F.S., and Tyree C. Manganese poisoning and the attack of trivalent manganese upon catecholamines. Arch. Biochem. Biophys. 256 (1987) 638-650
3. Aschner M., and Gannon M. Manganese transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms. Brain. Res. Bull. 33 (1994) 345-349
4. Chen J.Y., Tsao G.C., Zhao Q., and Zheng W. Differential cytotoxicity of Mn(II) and Mn(III): special reference to mitochondrial [Fe-S] containing enzymes. Toxicol. Appl. Pharmacol. 175 (2001) 160-168
5. Chua A.C., and Morgan E.H. Manganese metabolism is impaired in the Belgrade laboratory rat. J. Comp. Physiol. 167 (1997) 361-369
6. Cotzias G.C., Horiuchi K., Fuenzalida S., and Mena I. Chronic manganese poisoning. Clearance of tissue manganese concentrations with persistence of the neurological picture. Neurology 18 (1968) 376-382
7. Crossgrove J.S., and Yokel R.A. Manganese distribution across the blood-brain barrier III; the divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake. Neurotoxicology 25 (2004) 451-460
8. Davidsson L., Lonnerdal B., Sandstrom B., Kunz C., and Keen C.L. Identification of transferrin as the major plasma carrier protein for manganese introduced orally or intravenously or after in vitro addition in the rat. J Nutr 119 (1989) 1461-1464
9. Davson H., and Segal M.B. In: Davson H., and Segal MB. (Eds). Physiology of the CSF and blood-brain barriers (1996), CRC Press, New York
10. Dickinson T.K., Devenyi A.G., and Connor J.R. Distribution of injected iron-59 and manganese-54 in hypotransferrinemic mice. J Lab Clin Med 128 (1996) 270-278
11. Dorman D.C., Struve M.F., James R.A., McManus B.E., Marshall M.W., and Wong B.A. Influence of dietary manganese on the pharmacokinetics of inhaled manganese sulfate in male CD rats. Toxicol Sci 60 (2001) 242-251
12. Garrick M.D., and Dolan K.G. An expression system for a transporter of iron and other metals. Methods Mol Biol 196 (2002) 147-154
13. Gibbons R.A., Dixon S.N., Hallisk K., Russell A.M., Sansom B.F., and Symonds H.W. Manganese metabolism in cows and goats. Biochem Biophys Acta 444 (1976) 1-10
14. Gunter T.E., Miller L.M., Gavin C.E., Eliseev R., Salter J., Buntinas L., et al. Determination of the oxidation states of manganese in brain, liver, and heart mitochondria. J Neurochem 88 (2004) 266-280
15. Gunter K.K., Miller L.M., Aschner M., Eliseev R., Depuis D., Gavin C.E., et al. XANES spectroscopy: a promising tool for toxicology: a tutorial. Neurotoxicology 23 (2002) 127-146
16. HaMai D., Campbell A., and Bondy S.C. Modulation of oxidative events by multivalent manganese complexes in brain tissue. Free Radic Biol Med 31 (2001) 763-768
17. Jacobs J.N. Blood-brain and blood-nerve barriers and their relationships. In: Chang L.W. (Ed). Principles of neurotoxicology (1994), Marcel Dekker Inc., New York, NY 35-68
18. Kim R.B., Fromm M.F., Wandel C., Leake B., Wood A.J., Roden D.M., et al. The drug transporter p-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 101 (1998) 289-294
19. Newland M.C., Cox C., Hamada R., Oberdorster G., and Weiss B. The clearance of manganese chloride in the primate. Fund Appl Toxicol 9 (1987) 314-328
20. Rabin O., Hegedus L., Bourre J.M., and Smith Q.R. Rapid brain uptake of manganese(II) across the blood-brain barrier. J Neurochem 61 (1993) 509-517
21. Risau W. Differentiation of endothelium. FASEB J 9 (1995) 926-933
22. Roth J.A., and Garrick M.D. Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol 66 (2003) 1-13
23. Schinkel A.H., Wagenaar E., Mol C.A., and van Deemter L. p-Glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97 (1996) 2517-2524
24. St-Pierre M.V., Ugele B., Gambling L., and Shiverick K.T. Mechanisms of drug transfer across the human placenta-a workshop report. Placenta Suppl. A (2002) 159-164
25. Suzuki H., Terasaki T., and Sugiyama Y. Role of efflux transport across the blood-brain and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system. Adv Drug Deliv Rev 25 (1997) 257-285
26. Takeda A., Sawashita J., and Okada S. Biological half-lives of zinc and manganese in rat brain. Brain Res 695 (1985) 53-58
27. Yokel R.A., Crossgrove J.S., and Bukaveckas B.L. Manganese distribution across the blood-brain barrier. II. Manganese efflux from the brain does not appear to be carrier mediated. Neurotoxicology 24 (2003) 15-22
28. Yokel RA. Synopsis of Research Report 119. Manganese transport at the blood-brain barrier. The Health Effect Institute (HEI), 2004. http://www.healtheffects.org/Pubs/st119.htm.