Clopidogrel reduces the development of transplant arteriosclerosis

Journal of Thoracic and Cardiovascular Surgery

Volumn 131, Issue 5, 2006, Pages 1161-1166

  Abele, Silke ^a   Weyand, Michael ^a   Wollin, Martina ^a   Hiemann, Nicola E ^b   Harig, Frank ^a   Fischlein, Teddy ^a   Ensminger, Stephan M ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CLOPIDOGREL; SODIUM CHLORIDE;

ARTICLE; ATHEROSCLEROSIS; BLOOD ANALYSIS; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; GRAFT REJECTION; HISTOLOGY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; ISOGRAFT; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOTHERAPY; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; VASCULAR LESION;

ANIMALS; AORTA; ARTERIOSCLEROSIS; DISEASE MODELS, ANIMAL; GRAFT REJECTION; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE; TRANSPLANTATION, HOMOLOGOUS;

EID: 33646169594     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2006.01.010     Document Type: Article

References (34)

1. Hertz M.I., Taylor D.O., and Trulock E.P. The Registry of the International Society for Heart and Lung Transplantation. nineteenth official report-2002. J Heart Lung Transplant 21 (2002) 950-970
2. Weis M., and von Scheidt W. Coronary artery disease in the transplanted heart. Annu Rev Med 51 (2000) 81-100
3. Lietz K., and Miller L.W. Current understanding and management of allograft vasculopathy. Semin Thorac Cardiovasc Surg 16 (2004) 386-394
4. Ross R. The pathogenesis of atherosclerosis. a perspective for the 1990s. Nature 362 (1993) 801-809
5. Huo Y., and Ley K.F. Role of platelets in the development of atherosclerosis. Trends Cardiovasc Med 14 (2004) 18-22
6. Henn V., Slupsky J.R., Grafe M., et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391 (1998) 591-594
7. Gawaz M. Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium. Cardiovasc Res 61 (2004) 498-511
8. Fateh-Moghadam S., Bocksch W., Ruf A., et al. Changes in surface expression of platelet membrane glycoproteins and progression of heart transplant vasculopathy. Circulation 102 (2000) 890-897
9. Hognestad A., Michelsen A., Brosstad F., et al. Platelet activation in heart transplant recipients. Clin Transplant 18 (2004) 142-147
10. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348 (1996) 1329-1339
11. Investigators TC. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345 (2001) 494-502
12. Hollopeter G., Jantzen H.M., Vincent D., et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409 (2001) 202-207
13. Santa-Cruz R.A., and Steinhubl S.R. Clopidogrel. how good is it and how does it work?. Curr Cardiol Rep 6 (2004) 264-268
14. Savi P., Pereillo J.M., Uzabiaga M.F., et al. Identification and biological activity of the active metabolite of clopidogrel. Thromb Haemost 84 (2000) 891-896
15. Ensminger S.M., Billing J.S., Morris P.J., and Wood K.J. Development of a combined cardiac and aortic transplant model to investigate the development of transplant arteriosclerosis in the mouse. J Heart Lung Transplant 19 (2000) 1039-1046
16. Koulack J., McAlister V.C., Giacomantonio C.A., Bitter-Suermann H., MacDonald A.S., and Lee T.D. Development of a mouse aortic transplant model of chronic rejection. Microsurgery 16 (1995) 110-113
17. Ensminger S.M., Witzke O., Spriewald B.M., et al. CD8+ T cells contribute to the development of transplant arteriosclerosis despite cd154 blockade. Transplantation 69 (2000) 2609-2613
18. Ensminger S.M., Spriewald B.M., Witzke O., et al. Kinetics of transplant arteriosclerosis in MHC-Class I mismatched and fully allogeneic mouse aortic allografts. Transplantation 73 (2002) 1068-1074
19. Libby P., and Pober J.S. Chronic rejection. Immunity 14 (2001) 387-397
20. Lefer A.M. Platelets. unindicted coconspirators in inflammatory tissue injury. Circ Res 87 (2000) 1077-1078
21. Mayadas T.N., Johnson R.C., Rayburn H., Hynes R.O., and Wagner D.D. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74 (1993) 541-554
22. Kaplan D.R., Chao F.C., Stiles C.D., Antoniades H.N., and Scher C.D. Platelet alpha granules contain a growth factor for fibroblasts. Blood 53 (1979) 1043-1052
23. Khandoga A., Biberthaler P., Enders G., et al. Platelet adhesion mediated by fibrinogen-intercelllular adhesion molecule-1 binding induces tissue injury in the postischemic liver in vivo. Transplantation 74 (2002) 681-688
24. Yu G., Rux A.H., Ma P., Bdeir K., and Sachais B.S. Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner. Blood 105 (2005) 3545-3551
25. Stoica S.C., Goddard M., and Large S.R. The endothelium in clinical cardiac transplantation. Ann Thorac Surg 73 (2002) 1002-1008
26. Dietrich H., Hu Y., Zou Y., et al. Mouse model of transplant arteriosclerosis. role of intercellular adhesion molecule-1. Arterioscler Thromb Vasc Biol 20 (2000) 343-352
27. Koskinen P.K., and Lemstrom K.B. Adhesion molecule P-selectin and vascular cell adhesion molecule-1 in enhanced heart allograft arteriosclerosis in the rat. Circulation 95 (1997) 191-196
28. Lemstrom K., Sihvola R., and Koskinen P. Expression of platelet-derived growth factor in the development of cardiac allograft vasculopathy in the rat. Transplant Proc 29 (1997) 1045-1046
29. Larsen C.P., Alexander D.Z., Hollenbaugh D., et al. CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 61 (1996) 4-9
30. Ensminger S.M., Spriewald B.M., Sorensen H.V., et al. Critical role for IL-4 in the development of transplant arteriosclerosis in the absence of CD40-CD154 costimulation. J Immunol 167 (2001) 532-541
31. Graff J., Klinkhardt U., Schini-Kerth V.B., et al. Close relationship between the platelet activation marker CD62 and the granular release of platelet-derived growth factor. J Pharmacol Exp Ther 300 (2002) 952-957
32. Peters H., Eisenberg R., Daig U., et al. Platelet inhibition limits TGF-beta overexpression and matrix expansion after induction of anti-thy1 glomerulonephritis. Kidney Int 65 (2004) 2238-2248
33. Le Moine A., Flamand V., Demoor F.X., et al. Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection. J Clin Invest 103 (1999) 1659-1667
34. Molero L., Lopez-Farre A., Mateos-Caceres P.J., et al. Effect of clopidogrel on the expression of inflammatory markers in rabbit ischemic coronary artery. Br J Pharmacol 146 (2005) 419-424