Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit: Differences in structure and function relative to unliganded UL44

Journal of Biological Chemistry

Volumn 281, Issue 8, 2006, Pages 5224-5232

  Appleton, Brent A ^a,b   Brooks, Justin ^a,c   Loregian, Arianna ^a,d   Filman, David J ^a   Coen, Donald M ^a   Hogle, James M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b GENENTECH INC   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CRYSTAL STRUCTURE; CYTOLOGY; HYDROPHOBICITY; POLYMERS; PROTEINS; VIRUSES;

CELL NUCLEAR ANTIGEN; CYTOMEGALOVIRUS DNA POLYMERASE;

DNA;

DNA POLYMERASE; PROTEIN UL30; PROTEIN UL42; PROTEIN UL44; PROTEIN UL54; UNCLASSIFIED DRUG; VIRUS PROTEIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE; ICP36 PROTEIN, CYTOMEGALOVIRUS; LIGAND; PEPTIDE; UL54 PROTEIN, HUMAN HERPESVIRUS 5;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOMEGALOVIRUS; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ENZYMOLOGY; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; SIMPLEXVIRUS;

CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOMEGALOVIRUS; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; VIRAL PROTEINS;

EID: 33646167477     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M506900200     Document Type: Article

References (60)

1. Jeruzalmi, D., O'Donnell, M., and Kuriyan, J. (2002) Curr. Opin. Struct. Biol. 12, 217-224
2. Wu, C. A., Nelson, N. J., McGeoch, D. J., and Challberg, M. D. (1988) J. Virol. 62, 435-443
3. Pari, G. S., and Anders, D. G. (1993) J. Virol. 67, 6979-6988
4. Pari, G. S., Kacica, M. A., and Anders, D. G. (1993) J. Virol. 67, 2575-2582
5. Heilbronn, R., Jahn, G., Burkle, A., Freese, U. K., Fleckenstein, B., and zur Hausen, H. (1987) J. Virol. 61, 119-124
6. Kouzarides, T., Bankier, A. T., Satchwell, S. C., Weston, K., Tomlinson, P., and Barrell, B. G. (1987) J. Virol. 61, 125-133
7. Ertl, P. F., and Powell, K. L. (1992) J. Virol. 66, 4126-4133
8. Cihlar, T., Fuller, M. D., and Cherrington, J. M. (1997) Protein Expression Purif. 11, 209-218
9. Mar, E. C., Chiou, J. F., Cheng, Y. C., and Huang, E. S. (1985) J. Virol. 56, 846-851
10. Nishiyama, Y., Maeno, K., and Yoshida, S. (1983) Virology 124, 221-231
11. Gottlieb, J., Marcy, A. I., Coen, D. M., and Challberg, M. D. (1990) J. Virol. 64, 5976-5987
12. Loregian, A., Appleton, B. A., Hogle, J. M., and Coen, D. M. (2004) J. Virol. 78, 158-167
13. Weiland, K. L., Oien, N. L., Homa, F., and Wathen, M. W. (1994) Virus Res. 34, 191-206
14. Gibson, W., Murphy, T. L., and Roby, C. (1981) Virology 111, 251-262
15. Appleton, B. A., Loregian, A., Filman, D. J., Coen, D. M., and Hogle, J. M. (2004) Mol. Cell 15, 233-244
16. Zuccola, H. J., Filman, D. J., Coen, D. M., and Hogle, J. M. (2000) Mol. Cell 5, 267-278
17. Gulbis, J. M., Kelman, Z., Hurwitz, J., O'Donnell, M., and Kuriyan, J. (1996) Cell 87, 297-306
18. Krishna, T. S., Kong, X. P., Gary, S., Burgers, P. M., and Kuriyan, J. (1994) Cell 79, 1233-1243
19. Loregian, A., Appleton, B. A., Hogle, J. M., and Coen, D. M. (2004) J. Virol. 78, 9084-9092
20. Thornton, K. E., Chaudhuri, M., Monahan, S. J., Grinstead, L. A., and Parris, D. S. (2000) Virology 275, 373-390
21. Weisshart, K., Chow, C. S., and Coen, D. M. (1999) J. Virol. 73, 55-66
22. Parris, D. S., Cross, A., Haarr, L., Orr, A., Frame, M. C., Murphy, M., McGeoch, D. J., and Marsden, H. S. (1988) J. Virol. 62, 818-825
23. Gottlieb, J., and Challberg, M. D. (1994) J. Virol. 68, 4937-4945
24. Chen, X., Lin, K., and Ricciardi, R. P. (2004) J. Biol. Chem. 279, 28375-28386
25. Randell, J. C., and Coen, D. M. (2004) J. Mol. Biol. 335, 409-413
26. Crute, J. J., and Lehman, I. R. (1989) J. Biol. Chem. 264, 19266-19270
27. Gallo, M. L., Jackwood, D. H., Murphy, M., Marsden, H. S., and Parris, D. S. (1988) J. Virol. 62, 2874-2883
28. Digard, P., Bebrin, W. R., Weisshart, K., and Coen, D. M. (1993) J. Virol. 67, 398-406
29. Loregian, A., Rigatti, R., Murphy, M., Schievano, E., Palu, G., and Marsden, H. S. (2003) J. Virol. 77, 8336-8344
30. Bridges, K. G., Hua, Q., Brigham-Burke, M. R., Martin, J. D., Hensley, P., Dahl, C. E., Digard, P., Weiss, M. A., and Coen, D. M. (2000) J. Biol. Chem. 275, 472-478
31. Bridges, K. G., Chow, C. S., and Coen, D. M. (2001) J. Virol. 75, 4990-4998
32. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
33. Terwilliger, T. C., and Berendzen, J. (1999) Acta Crystallogr. Sect. D Biol. Crystallogr. 55, 849-861
34. Terwilliger, T. C. (2000) Acta Crystallogr. Sect. D Biol. Crystallogr. 56, 965-972
35. McRee, D. E. (1999) J. Struct. Biol. 125, 156-165
36. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect.D Biol. Crystallogr. 53, 240-255
37. Laskowski, R. A., MacAurthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
38. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
39. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
40. Lawrence, M. C., and Colman, P. M. (1993) J. Mol. Biol. 234, 946-950
41. Vivona, J. B., and Kelman, Z. (2003) FEBS Lett. 546, 167-172
42. Maga, G., and Hubscher, U. (2003) J. Cell Sci. 116, 3051-3060
43. Chapados, B. R., Hosfield, D. J., Han, S., Qiu, J., Yelent, B., Shen, B., and Tainer, J. A. (2004) Cell 116, 39-50
44. Bruning, J. B., and Shamoo, Y. (2004) Structure (Camb.) 12, 2209-2219
45. Sakurai, S., Kitano, K., Yamaguchi, H., Hamada, K., Okada, K., Fukuda, K., Uchida, M., Ohtsuka, E., Morioka, H., and Hakoshima, T. (2005) EMBO J. 24, 683-693
46. Matsumiya, S., Ishino, S., Ishino, Y., and Morikawa, K. (2002) Genes Cells 7, 911-922
47. Bowman, G. D., O'Donnell, M., and Kuriyan, J. (2004) Nature 429, 724-730
48. Shamoo, Y., and Steitz, T. A. (1999) Cell 99, 155-166
49. Kong, X. P., Onrust, R., O'Donnell, M., and Kuriyan, J. (1992) Cell 69, 425-437
50. Jeruzalmi, D., Yurieva, O., Zhao, Y., Young, M., Stewart, J., Hingorani, M., O'Donnell, M., and Kuriyan, J. (2001) Cell 106, 417-428
51. Bunting, K. A., Roe, S. M., and Pearl, L. H. (2003) EMBO J. 22, 5883-5892
52. Burnouf, D. Y., Olieric, V., Wagner, J., Fujii, S., Reinbolt, J., Fuchs, R. P., and Dumas, P. (2004) J. Mol. Biol. 335, 1187-1197
53. Pages, V., and Fuchs, R. P. (2002) Oncogene 21, 8957-8966
54. Coen, D. M., and Schaffer, P. A. (2003) Nat. Rev. Drug Discov. 2, 278-288
55. Ripalti, A., Boccuni, M. C., Campanini, F., and Landini, M. P. (1995) J. Virol. 69, 2047-2057
56. Digard, P., Williams, K. P., Hensley, P., Brooks, I. S., Dahl, C. E., and Coen, D. M. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1456-1460
57. Pilger, B. D., Cui, C., and Coen, D. M. (2004) Chem. Biol. 11, 647-654
58. Loregian, A., and Coen, D. M. (2006) Chem. Biol., in press
59. Hayward, S., and Berendsen, H. J. (1998) Proteins 30, 144-154
60. Makhov, A. M., Subramanian, D., Holley-Guthrie, E., Kenney, S. C., and Griffith, J. D. (2004) J. Biol. Chem. 279, 40358-40361