Characterization of the neuronal dopamine transporter DAT in human blood platelets

Neuroscience Letters

Volumn 399, Issue 3, 2006, Pages 197-201

  Frankhauser, Pascal ^a   Grimmer, Yvonne ^a   Bugert, Peter ^b   Deuschle, Michael ^a   Schmidt, Martin ^a   Schloss, Patrick ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Dopamine transporter (DAT); Expression; mRNA; Platelets; Protein

Indexed keywords

DOPAMINE TRANSPORTER;

ARTICLE; CONTROLLED STUDY; DRUG ABUSE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MENTAL DISEASE; MICROARRAY ANALYSIS; NERVE CELL; PERIPHERAL NERVE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE;

BLOOD PLATELETS; BLOTTING, NORTHERN; BLOTTING, WESTERN; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 33646163886     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.01.062     Document Type: Article

References (33)

1. Amenta F., Bronzetti E., Cantalamessa F., El-Assouad D., Felici L., Ricci A., and Tayebati S.K. Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. J. Neuroimmunol. 117 (2001) 133-142
2. Barkan T., Gurwitz D., Levy G., Weizman A., and Rehavi M. Biochemical and pharmacological characterization of the serotonin transporter in human peripheral blood lymphocytes. Eur. Neuropsychopharmacol. 14 (2004) 237-243
3. Benmansour S., Cecchi M., Morilak D.A., Gerhardt G.A., Javors M.A., Gould G.G., and Frazer A. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. J. Neurosci. 19 (1999) 10494-10501
4. Bjerggaard C., Fog J.U., Hastrup H., Madsen K., Loland C.J., Javitch J.A., and Gether U. Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions. J. Neurosci. 24 (2004) 7024-7036
5. Bugert P., Dugrillon A., Günaydin A., Eichler H., and Klüter H. Messenger RNA profiling of human platelets by microarray hybridisation. Thromb. Haemost. 90 (2003) 748-758
6. Caronti B., Antonini G., Calderaro C., Ruggieri S., Palladini G., Pontieri F.E., and Colosimo C. Dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. J. Neural. Transm. 108 (2001) 803-807
7. Chen N.H., Reith M.E., and Quick M.W. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflugers Arch. 447 (2004) 519-531
8. 3H]dopamine uptake mechanism. Life Sci. 50 (1992) 341-347
9. Dean B., McAdam A.J., Sundram S., Pavey G., Harrison L.C., and Copolov D.L. Identification of a dopamine-binding protein on the membrane of the human platelet. Biochem. J. 287 (1992) 45-50
10. Eshleman A.J., Neve R.L., Janowsky A., and Neve K.A. Characterization of a recombinant human dopamine transporter in multiple cell lines. J. Pharmacol. Exp. Ther. 274 (1995) 276-283
11. Horschitz S., Hummerich R., and Schloss P. Down-regulation of the rat serotonin transporter upon exposure to a selective serotonin reuptake inhibitor. Neuroreport 12 (2001) 2181-2184
12. Hummerich R., Reischl G., Ehrlichmann W., Machulla H.J., Heinz A., and Schloss P. DASB -in vitro binding characteristics on human recombinant monoamine transporters with regard to its potential as positron emission tomography (PET) tracer. J. Neurochem. 90 (2004) 1218-1226
13. 3H]-dopamine uptake displayed by native lymphocyte suspensions is mainly due to contaminating platelets. Pharmacopsychiatry 31 (1998) 193-198
14. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
15. Langer S.Z., and Galzin A.M. Studies on the serotonin transporter in platelets. Experientia 44 (1988) 127-130
16. Lesch K.P., Wolozin B.L., Murphy D.L., and Riederer P. Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J. Neurochem. 60 (1993) 2319-2322
17. Lingjaerde O., and Kildemo O. Dopamine uptake in platelets: two different low-affinity, saturable mechanisms. Agents Actions 11 (1981) 410-416
18. Little K.Y., Elmer L.W., Zhong H., Scheys J.O., and Zhang L. Cocaine induction of dopamine transporter trafficking to the plasma membrane. Mol. Pharmacol. 61 (2002) 436-445
19. 3H]WIN 35428 binding sites in human striatum. Brain Res. 628 (1993) 17-25
20. Little K.Y., Zhang L., Desmond T., Frey K.A., Dalack G.W., and Cassin B.J. Striatal dopaminergic abnormalities in human cocaine users. Am. J. Psychiatry 156 (1999) 238-245
21. Markwell M., Hass S.N., Brecker L., and Tolbert N. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Annal. Biochem. 87 (1978) 206-210
22. Miranda M., Sorkina T., Grammatopoulos T.N., Zawada W.M., and Sorkin A. Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum. J. Biol. Chem. 279 (2004) 30760-30770
23. Owens M.J., and Nemeroff C.B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin. Chem. 40 (1994) 288-295
24. Pandey G.N. Altered serotonin function in suicide. Evidence from platelet and neuroendocrine studies. Ann. N. Y. Acad. Sci. 836 (1997) 182-200
25. Pineyro G., Blier P., Dennis T., and de Montigny C. Desensitization of the neuronal 5-HT carrier following its long-term blockade. J. Neurosci. 14 (1994) 3036-3047
26. Purselle D.C., and Nemeroff C.B. Serotonin transporter: a potential substrate in the biology of suicide. Neuropsychopharmacology 28 (2003) 613-619
27. Rausch J.L., Johnson M.E., Li J., Hutcheson J., Carr B.M., Corley K.M., Gowans A.B., and Smith J. Serotonin transport kinetics correlated between human platelets and brain synaptosomes. Psychopharmacology 180 (2005) 391-398
28. Reith M.E.A. Neurotransmitter transporters. In: Reith M.E.A. (Ed). Structure, Function and Regulation. second ed. (2002), Humana Press, Totowa, NJ
29. 3H]WIN 35, 428) binding. Biochem. Pharmacol. 52 (1996) 1435-1446
30. Rolf N., Knoefler R., Suttorp M., Kluter H., and Bugert P. Optimized procedure for platelet RNA profiling from blood samples with limited platelet numbers. Clin. Chem. 51 (2005) 1078-1080
31. Rox J.M., Bugert P., Müller J., Schorr A., Hanfland P., Madlener P., Klüter H., and Pötzsch B. Gene expression analysis in single donor platelets: Evaluation of a PCR-based amplification technique. Clin. Chem. 50 (2004) 2271-2278
32. Shimada S., Kitayama S., Lin C.L., Patel A., Nanthakumar E., Gregor P., Kuhar M., and Uhl G. Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science 254 (1991) 576-578
33. Zhu M.Y., Blakely R.D., Apparsundaram S., and Ordway G.A. Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine. J. Neurochem. 70 (1998) 1547-1555