Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus

Circulation Research

Volumn 98, Issue 7, 2006, Pages 866-867

  Harder, David R ^a   Roman, Richard J ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

20 HETE; CYP450; CYP4A2; Endothelial dysfunction; Hypertension

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; CYTOCHROME P450 4A; CYTOCHROME P450 4A2; UNCLASSIFIED DRUG; 20 HYDROXY 5,8,11,14 EICOSATETRAENOIC ACID; 20-HYDROXY-5,8,11,14-EICOSATETRAENOIC ACID; ARACHIDONIC ACID; CYTOCHROME P 450 CYP4A2 (RAT); CYTOCHROME P-450 CYP4A2 (RAT); CYTOCHROME P450; HYDROXYICOSATETRAENOIC ACID;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARACHIDONIC ACID METABOLISM; CONTROLLED STUDY; EDITORIAL; ENDOTHELIAL DYSFUNCTION; GENE CLUSTER; GENETIC TRANSDUCTION; HYPERTENSION; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VIRUS INFECTION; ANIMAL; BIOLOGICAL MODEL; GENETICS; METABOLISM; NOTE; PHYSIOLOGY;

ADENOVIRIDAE; ANIMALS; ARACHIDONIC ACID; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIUM, VASCULAR; HYDROXYEICOSATETRAENOIC ACIDS; HYPERTENSION; MODELS, BIOLOGICAL; RATS; TRANSDUCTION, GENETIC;

EID: 33646145520     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000219822.06364.19     Document Type: Editorial

References (11)

1. Harder DR, Alkayed NJ, Lange AR, Gebremedhin D, Roman RJ. Functional hyperemia in the brain: hypothesis for astrocyte-derived vasodilator metabolites. Stroke. 1998;29:229-234.
2. Makita K, Falck JR, Capdevila JH. Cytochrome P-450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system. FASEB J. 1996;10:1456-1463.
3. McGiff JC, Quilley J. 20-HETE and the kidney: resolution of old problems and new beginnings. Am J Physiol Regulatory Integrative Comp Physiolo. 1999;277:R607-R623.
4. Roman RJ, Alonso-Galicia M. P-450 eicosanoids: a novel signaling pathway regulating renal function. News Physiol Sci. 1999;14:238-242.
5. Morrison AR, Pascoe N. Metabolism of arachidonate through NADPH-dependent oxygenase of renal cortex. Proc Nat Acad Sci USA. 1981;78:7375-7378.
6. Capdevila J, Chocos N, Werringloer J, Prough RA, Estabrook RW. Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid. Proc Natl Acad Sci U S A. 1981;78:5362-5366.
7. Oliw EH, Lawson JA, Brash AR, Oates JA. Arachidonic acid metabolism in rabbit renal cortex. Formation of two novel dihydroxyeicosatrienoic acids. J Biol Chem. 1981;256:9924-9931.
8. Escalante B, Sacerdoti D, Davidian MM, Laniado-Schwartzman M, McGiff JC. Chronic treatment with tin normalizes blood pressure in spontaneously hypertensive rats. Hypertension. 1991;17:776-779.
9. Levere RD, Martasek P, Escalante B, Schwartzman ML, Abraham NG. Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats. J Clin Invest. 1990;86:213-219.
10. Sacerdoti D, Escalante B, Abraham NG, McGiff JC, Levere RD, Schwartzman ML. Treatment with tin prevents the development of hypertension in spontaneously hypertensive rats. Science. 1989;243:388-390.
11. Wang J-S, Singh H, Zhang F, Ishizuka T, Deng H, Kemp R, Wolin MS, Hintze TH, Abraham NG, Nasjletti A, Laniado-Schwartzman M. Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. Circ Res. 2006;98:962-969.