Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice

Physiology and Behavior

Volumn 87, Issue 5, 2006, Pages 842-847

  Harvey, Deirdre ^a   Smith, Roisin ^a   English, Karen ^a   Mahon, Bernard ^a   Commins, Sean ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Balb c; Cytokine; Exploration; Habituation; Interleukin 10; Lipopolysaccharide

Indexed keywords

CYTOKINE; INTERLEUKIN 10; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; EXPLORATORY BEHAVIOR; FEEDING; HABITUATION; LEARNING; LEARNING DISORDER; MALE; MOTIVATION; MOTOR ACTIVITY; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TASK PERFORMANCE; WEIGHT REDUCTION;

EID: 33646140809     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2006.03.002     Document Type: Article

References (30)

1. Bluthé R.-M., Castanon N., Pousset F., Bristow A., Ball C., Lestage J., et al. Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats. Psychoneuroendocrinology 24 (1999) 301-311
2. Sparkman N.L., Kohman R.A., Garcia A.K., and Boehm G.W. Peripheral lipopolysaccharide administration impairs two-way active avoidance conditioning in C57BL/6J mice. Physiol Behav 85 (2005) 278-288
3. Hart B.L. Biological basis of the behaviour of sick animals. Neurosci Biobehav Rev 12 (1998) 123-137
4. Rivier C., Chizzonite R., and Vale W. In the mouse, activation of the hypothalamic-pituitary-adrenal axis by lipopolysaccharide (endotoxin) is mediated through Interleukin-1. Endocrinology 125 (1989) 2800-2805
5. Arai K., Matsuki N., Ikegaya Y., and Nishiyama N. Deterioration of spatial performance in lipopolysaccharide-treated mice. Jpn J Pharmacol 87 (2001) 195-201
6. Pugh C.R., Kumagawa K., Fleshner M., Watkins L.R., Maier S.F., and Rudy J.W. Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning. Brain Behav Immun 12 (1998) 212-229
7. Shaw K.N., Commins S., and O'Mara S.M. Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus. Behav Brain Res 124 (2001) 47-54
8. Hauss-Wegrzyniak B., Vannucchi M.G., and Wenk G.L. Behavioural and ultrastructural changes induced by chronic neuroinflammation in young rats. Brain Res 59 (2000) 157-166
9. Sell K.M., Crowe S.F., and Kent S. Lipopolysaccharide induces biochemical alterations in chicks trained on the passive avoidance learning task. Physiol Behav 78 (2003) 679-688
10. Sparkman N.L., Martin L.A., Calvert W.S., and Boehm G.W. Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and two-month-old female C57BL/6J mice. Behav Brain Res 159 (2005) 145-151
11. Yirmiya R., Winocur G., and Goshen I. Brain Interleukin-1 is involved in spatial memory and passive avoidance conditioning. Neurobiol Learn Mem 78 (2002) 370-389
12. Gahtan E., and Overmier J.B. Performance more than working memory disrupted by acute systemic inflammation in rats in appetitive tasks. Physiol Behav 73 (2001) 201-210
13. deWall Malefyt R., Haanen J., Spits H., Roncarolo M.G., deVelde A., Figdor C., et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down regulation of class II major histocompatibility complex expression. J Exp Med 174 (1991) 915-924
14. Fiorentino D.F., Zlotnik A., Mosmann J.R., Howard M., and O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 147 (1991) 3815-3822
15. Dinarello C.A. Modalities for reducing Interleukin 1 activity in disease. TiPS 14 (1993) 155-159
16. Moore K.W., deWaal Malefyt R., Coffman R.L., and O'Garra A. Interleukin-10 and the Interleukin-10 receptor. Annu Rev Immunol 19 (2001) 683-765
17. Smith E.M., Cadet P., Stefano G.B., Opp M.R., and Hughes T.K. IL-10 as a mediator in the HPA axis and brain. J Neuroimmunol 100 1-2 (1999) 140-148
18. Leon L.R., Kozak W., Rudolph K., and Kluger M.J. An antipyretic role for IL-10 in fever. Am J Physiol 276 (1999) 81-89
19. Nava F., Calapai G., Facciolá G., Cuzzocrea S., Marciano M.C., DeSarro A., et al. Effects of Interleukin-10 on water intake, locomotory activity, and rectal temperature in rat treated with endotoxin. Int J Immunopharmacol 19 (1997) 31-38
20. Opp M.R., Smith E.M., and Hughes T.K. Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep. J Neuroimmunol 60 (1995) 165-168
21. Granon S., Save E., and Buhot M.C. Effortful information processing in a spontaneous spatial situation by rats with medial prefrontal lesion. Behav Brain Res 78 (1996) 147-154
22. Poucet B. Object exploration, habituation, and response to a spatial change in rats following septal or medial frontal cortical damage. Behav Neurosci 103 5 (1989) 1009-1016
23. Galani R., Weiss I., Cassel J.C., and Kelche C. Spatial memory, habituation and reactions to spatial and nonspatial changes in rats with selective lesions of the hippocampus, the entorhinal cortex or the subiculum. Behav Brain Res 96 (1998) 1-12
24. Craig S., Cunningham L., Kelly L., and Commins S. Long-term retention and overshadowing of proximal and distal cues following habituation in an object exploration task. Behav Processes 68 (2005) 117-128
25. Kent S., Bluth R.M., Kelley K.W., and Dantzer R. Sickness behaviour as a new target for drug development. Trends Pharmacol Sci 13 (1992) 24-28
26. Barnett S.A. The rat: a study in behaviour (1963), Aldine, Chicago
27. Treit D., and Fundytus M. Thigmotaxis as a test for anxiolytic activity in rats. Pharmacol Biochem Behav 31 (1989) 959-962
28. Creed R.P., and Miller J.R. Interpreting animal wall-following behaviour. Experientia 46 (1990) 758-761
29. Webster D.G., Baumgardner D.J., and Dewsbury D.A. Open-field behaviour in eight taxa of muroid rodents. Bull Psychon Soc 13 (1979) 90-92
30. Wilson R.C., Vacek T., Lanier D.L., and Dewsbury D.A. Open-field behaviour in muroid rodents. Behav Biol 17 (1976) 495-506