Effect of intravenous amino acids on glutamine and protein kinetics in low-birth-weight preterm infants during the immediate neonatal period

American Journal of Physiology - Endocrinology and Metabolism

Volumn 290, Issue 4, 2006, Pages

  Kadrofske, Mark M ^a   Parimi, Prabhu S ^a   Gruca, Lourdes L ^a   Kalhan, Satish C ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

Glutamine metabolism; Neonates; Protein metabolism; Stable isotope tracers; Very low birth weight

Indexed keywords

AMINO ACID DERIVATIVE; GLUCOSE; GLUTAMINE; INSULIN; LEUCINE; PHENYLALANINE; TRACER; UREA; AMINO ACID; HYDROCORTISONE; OXYGEN; PROTEIN;

AMINO ACID BLOOD LEVEL; ARTICLE; CITRIC ACID CYCLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; INSULIN BLOOD LEVEL; ISOTOPE TRACING; LOW BIRTH WEIGHT; NEWBORN; NEWBORN PERIOD; PREMATURITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; UREA CYCLE; BLOOD; CROSSOVER PROCEDURE; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; METABOLISM;

AMINO ACIDS; BLOOD GLUCOSE; CROSS-OVER STUDIES; GLUTAMINE; HUMANS; HYDROCORTISONE; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INFANT, PREMATURE; INFUSIONS, INTRAVENOUS; INSULIN; KINETICS; LEUCINE; OXYGEN; PHENYLALANINE; PROTEINS; UREA;

EID: 33646118013     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00274.2005     Document Type: Article

References (31)

1. 13C]leucine exchange. Eur J Clin Invest 20: 41-50, 1990.
2. 13C]leucine. Clin Sci (Lond) 76: 447-454, 1989.
3. Biolo G, Fleming RY, Maggi SP, Nguyen TT, Herndon DN, and Wolfe RR. Inhibition of muscle glutamine formation in hypercatabolic patients. Clin Sci (Lond) 99: 189-194, 2000.
4. Blomqvist BI, Hammarqvist F, von der Decken A, and Wernerman J. Glutamine and α-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement. Metabolism 44: 1215-1222, 1995.
5. Bohé J, Aili Low JF, Wolfe RR, and Rennie MJ. Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids. J Physiol 532: 575-579, 2001.
6. Brosnan JT. Interorgan amino acid transport and its regulation. J Nutr 133: 2068S-2072S, 2003.
7. Denne SC, Karn CA, Ahlrichs JA, Dorotheo AR, Wang J, and Liechty EA. Proteolysis and phenylalanine hydroxylation in response to parenteral nutrition in extremely premature and normal newborns. J Clin Invest 97: 746-754, 1996.
8. Hammarqvist F, Wernerman J, Ali R, von der Decken A, and Vinnars E. Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance. Ann Surg 208: 455-461, 1989.
9. Kalhan SC and Iben S. Protein metabolism in the extremely low-birth weight infant. Clin Perinatol 27: 23-56, 2000.
10. Kalhan SC, Parimi PS, Gruca LL, and Hanson RW. Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants. J Pediatr 146: 642-647, 2005.
11. Kalhan SC, Rossi KQ, Gruca L, Super DM, and Savin RM. Relation between transamination of branched chain amino acids and urea synthesis: evidence from human pregnancy. Am J Physiol Endocrinol Metab 275: E423-E431, 1998.
12. Kuhn KS, Schuhmann K, Stehle P, Darmaun D, and Fürst P. Determination of glutamine in muscle protein facilitates accurate assessment of proteolysis and de novo synthesis-derived endogenous glutamine production. Am J Clin Nutr 70: 484-489, 1999.
13. Lacey JM and Wilmore DW. Is glutamine a conditionally essential amino acid? Nutr Rev 48: 2979-309, 1990.
14. Lacey JM, Crouch JB, Benfell K, Ringer SA, Wilmore CK, Maguire D, and Wilmore DW. The effects of glutamine-supplemented parenteral nutrition in premature infants. J Parent Ent Nutr 20: 74-80, 1996.
15. Mittendorfer B, Gore DC, Herndon DN, and Wolfe RR. Accelerated glutamine synthesis in critically ill patients cannot maintain normal intramuscular free glutamine concentrations. J Parent Ent Nutr 23: 243-252, 1999.
16. Neu J, Roig J, Meetze WH, Veerman M, Carter C, Millsaps M, Bowling D, Dallas MJ, Sleasman J, Knight T, and Auestad N. Enteral glutamine supplementation for very low birth weight infants decreases morbidity. J Pediatr 131: 691-699, 1997.
17. Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr 131: 2515S-2522S, 2001.
18. Owen OE, Kalhan SC, and Hanson RW. The key role of anaplerosis and cataplerosis for citric acid cycle function. J Biol Chem 277: 30409-30412, 2002.
19. Parimi PS, Devapatla S, Gruca L, O'Brien AM, Hanson RW, and Kalhan S. Glutamine and leucine nitrogen kinetics and their relation to urea nitrogen in newborn infants. Am J Physiol Endocrinol Metab 282: E618-E625, 2002.
20. Parimi PS, Devapatla S, Gruca L, Amini SB, Hanson RW, and Kalhan S. Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very low birth weight infants. Am J Clin Nutr 79: 402-409, 2004.
21. Parimi PS, Kadrofske MM, Gruca LL, Hanson RW, and Kalhan SC. Amino acids, glutamine and protein metabolism in very low birth weight infants. Pediatr Res 58: 1259-1264, 2005.
22. Poindexter BB, Ehrenkranz RA, Stoll BJ, Wright LL, Poole WK, Oh W, Bauer CR, Papile LA, Tyson JE, Carlo WA, Laptook AR, Narendran V, Stevenson DK, Farnaroff AA, Korones SB, Shankaran S, Finer NN, Lemons JA, and National Institute of Child Health and Human Development Neonatal Research Network. Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infants. Pediatrics 113: 1209-1215, 2004.
23. Poindexter BB, Karn CA, Ahlrichs JA, Wang J, Leitch CA, Liechty EA, and Denne SC. Amino acids suppress proteolysis independent of insulin throughout the neonatal period. Am J Physiol Endocrinol Metab 272: E592-E599, 1997.
24. Poindexter BB, Karn CA, Leitch CA, Liechty EA, and Denne SC. Amino acids do not suppress proteolysis in premature neonates. Am J Physiol Endocrinol Metab 281: E472-E478, 2001.
25. Reeds PJ and Burrin DG. Glutamine and the bowel. J Nutr 131: 2505S-2508S, 2001.
26. Reeds PJ, Fjeld CR, and Jahoor F. Do the differences between the amino acid compositions of acute-phase and muscle proteins have a bearing on nitrogen loss in traumatic states? J Nutr 124: 906-910, 1994.
27. Thompson SW, McClure BG, and Tubman TR. A randomized, controlled trial of parenteral glutamine in ill, very low birth-weight neonates. J Parent Ent Nutr 37: 550-553, 2003.
28. van Eijk HM, Rooyakkers DR, and Deutz NE. Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2-3 μm Spherisorb ODS II column. J Chromatogr 620: 143-148, 1993.
29. Vaughn P, Thomas P, Clark R, and Neu J. Enteral glutamine supplementation and morbidity in low birth weight infants. J Pediatr 142: 662-668, 2003.
30. Watford M. Glutamine and glutamate metabolism across the liver sinusoid. J Nutr 130: 983S-987S, 2000.
31. Young VR and Ajami AM. Glutamine: the emperor or his clothes? J Nutr 131: 2449S-2459S, 2001.