Increased expression of α- and β-globin mRNAs at the pituitary following exposure to estrogen during the critical period of neonatal sex differentiation in the rat

Journal of Steroid Biochemistry and Molecular Biology

Volumn 99, Issue 1, 2006, Pages 33-43

  Leffers, H ^b   Navarro, V M ^a   Nielsen, John E ^b   Mayen, A ^a   Pinilla, L ^a   Dalgaard, M ^b   Malagon, M M ^a   Castano J P ^a   Skakkebaek, N E ^b   Aguilar, E ^a   Tena Sempere, M ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

Author keywords

Endocrine disruption; Estrogen; Globin; Pituitary; Rat; Sex differentiation

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; BIOLOGICAL MARKER; ENDOCRINE DISRUPTOR; ESTRADIOL BENZOATE; ESTROGEN; FLUTAMIDE; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; CEREBELLUM; CONTROLLED STUDY; GENE EXPRESSION; HYPOPHYSIS; HYPOTHALAMUS; IN SITU HYBRIDIZATION; LIVER; NEWBORN PERIOD; NONHUMAN; PUBERTY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEX DIFFERENTIATION; TESTIS; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL MARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS; FEMALE; GENITALIA, FEMALE; GENITALIA, MALE; GLOBINS; MALE; ORGAN SPECIFICITY; PITUITARY GLAND; RATS; RATS, WISTAR; RNA, MESSENGER; SEX DETERMINATION (GENETICS);

ANIMALIA;

EID: 33646117497     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2005.11.012     Document Type: Article

References (35)

1. Clark J.H., and Mani S.K. Actions of ovarian steroids. In: Knobil E., and Neill J.D. (Eds). The Physiology of Reproduction (1994), Raven Press, New York 1011-1062
2. Sharpe R.M. The roles of oestrogen in the male. Trends Endocrinol. Metab. 9 (1998) 371-377
3. Green S., Walter P., Kumar V., Krust A., Bornert J.-M., Argos P., and Chambon P. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320 (1986) 134-139
4. Kuiper G.G.J.M., Shughrue P.J., Merchenthaler I., and Gustafsson J.-A. The estrogen receptor β subtype: a novel mediator of estrogen actions in neuroendocrine systems. Front. Neuroendocrinol. 19 (1998) 253-286
5. White R., and Parker M.G. Molecular mechanisms of steroid hormone action. Endocr. Relat. Cancer 5 (1998) 1-14
6. Nadal A., Alonso-Magdalena P., Ripoll C., and Fuentes E. Disentangling the molecular mechanisms of action of endogenous and environmental estrogens. Pflugers Arch. 449 (2005) 335-343
7. McLachlan J.A., Burow M., Chiang T.-C., and Li S.F. Gene imprinting in developmental toxicology: a possible interface between physiology and pathology. Toxicol. Lett. 120 (2001) 161-164
8. Döhler K.D., and Hancke J.L. Thoughts on the mechanisms of sexual brain differentiation. In: Dorner G., and Kawakami M. (Eds). Hormones and Brain Development (1978), Elsevier, Amsterdam 153-158
9. MacLusky N.J., and Naftolin F. Sexual differentiation of the central nervous system. Science 211 (1981) 1294-1302
10. Tena-Sempere M., Pinilla L., Gonzalez L.C., and Aguilar E. Reproductive disruption by exposure to exogenous estrogenic compounds during sex differentiation: lessons from the neonatally estrogenized male rat. Curr. Topics Steroid Res. 3 (2000) 23-37
11. Toppari J., Larsen J.C., Christiansen P., Giwercman A., Grandjean P., Guillette Jr. L.J., Jegou B., Jensen T.K., Jouannet P., Keiding N., Leffers H., McLachlan J.A., Meyer O., Muller J., Rajpert-De Meyts E., Scheike T., Sharpe R., Sumpter J., and Skakkebaek N.E. Male reproductive health and environmental xenoestrogens. Environ. Health Perspect. 104 (1996) 741-803
12. Sharpe R.M. Lifestyle and environmental contribution to male infertility. Br. Med. Bull. 56 (2000) 630-642
13. Sikka S.C., and Naz R.K. Endocrine disruptors and male infertility. In: Naz R.K. (Ed). Endocrine Disruptors. Effects on Male and Female Reproductive Systems (1999), CRC Press, Boca Raton 225-246
14. Kelce W.R., and Gray L.E. Environmental antiandrogens as endocrine disruptors. In: Naz R.K. (Ed). Endocrine Disruptors. Effects on Male and Female Reproductive Systems (1999), CRC Press, Boca Raton 247-277
15. Boisen K.A., Main K.M., Rajpert-De Meyts E., and Skakkebaek N.E. Are male reproductive disorders a common entity? The testicular dysgenesis syndrome. Ann. N.Y. Acad. Sci. 948 (2001) 90-99
16. Skakkebaek N.E. Testicular dysgenesis syndrome. Horm. Res. 60 (2003) 49
17. Pinilla L., Tena-Sempere M., Gonzalez D., and Aguilar E. Mechanisms of altered LH secretion in neonatally oestrogenized male rats. J. Endocrinol. 147 (1995) 43-50
18. Williams K., McKinnell C., Saunders P.T., Walker M., Fisher J.S., Turner K.J., Atanassova N., and Sharpe R.M. Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of the androgen-oestrogen balance and assessment of the relevance to man. Hum. Reprod. Update 7 (2001) 236-247
19. Rivas A., Fisher J.S., McKinnell C., Atanassova N., and Sharpe R.M. Induction of reproductive tract developmental abnormalities in the male rat by lowering androgen production or action in combination with a low dose of diethylstilbestrol: evidence for importance of the androgen-estrogen balance. Endocrinology 143 (2002) 4794-4808
20. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
21. Jorgensen M., Bérvort M., Kledal T.S., Hansen B.V., Dalgaard M., and Leffers H. Differential display competitive polymerase chain reaction: an optimal tool for assaying gene expression. Electrophoresis 20 (1999) 230-240
22. Tena-Sempere M., Barreiro M.L., Gonzalez L.C., Pinilla L., and Aguilar E. Differential neonatal imprinting and regulation by estrogen of estrogen receptor subtypes α and β and of the truncated estrogen receptor product (TERP-1) mRNA expression in the male rat pituitary. Neuroendocrinology 74 (2001) 347-358
23. Tena-Sempere M., Navarro V.M., Mayen A., Bellido C., and Sanchez-Criado J.E. Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary. Biol. Reprod. 70 (2004) 671-678
24. Higuchi R., Fockler C., Dollinger G., and Watson R. Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology 11 (1993) 1026-1030
25. Nielsen J.E., Hansen M.A., Jørgensen M., Tanaka M., Almstrup K., Skakkebæk N.E., and Leffers H. Germ cell differentiation-dependent and stage-specific expression of LANC1 in rodent testis. Eur. J. Histochem. 47 (2003) 215-222
26. Liang P., and Pardee A.B. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257 (1992) 967-971
27. Singal R., vanWert J.M., and Ferdinand L. Methylation of α-type embryonic globin gene represses transcription in primary erythroid cells. Blood 100 (2002) 4217-4222
28. Bottardi S., Aumont A., Grosveld F., and Milot E. Developmental stage-specific epigenetic control of human beta-globin gene expression is potentiated in hematopoietic progenitor cells prior to their transcriptional activation. Blood 102 (2003) 3989-3997
29. Hashimshony T., Zhang J., Keshet I., Bustin M., and Cedar H. The role of DNA methylation in setting up chromatin structure during development. Nat. Genet. 34 (2003) 187-192
30. Li S., Washburn K.A., Moore R., Uno T., Teng C., Newbold R.R., McLachlan J.A., and Negishi M. Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus. Cancer Res. 57 (1997) 4356-4359
31. Pentecost B.T., Newbold R.R., Teng C.T., and McLachlan J.A. Prenatal exposure of male mice to diethylstilbestrol alter the expression of the lactotransferrin gene in seminal vesicles. Mol. Endocrinol. 2 (1988) 1243-1248
32. Xu R.K., Wu X.M., Di A.K., Xu J.N., Pang C.S., and Pang S.F. Pituitary prolactin-secreting tumor formation: recent developments. Biol. Sign. Recept. 9 (2000) 1-20
33. Bombail V., Moggs J.G., and Orphanides G. Perturbation of epigenetic status by toxicants. Toxicol. Lett. 149 (2004) 51-58
34. Tabb M.M., and Blumberg B. New modes of action for endocrine disrupting chemicals. Mol. Endocrinol. 20 (2005) 475-482
35. Hsieh Y.C., Yang S., Choudhry M.A., Yu H.P., Bland K.L., Schwacha M.G., and Chaudry I.H. Flutamide restores cardiac functions following trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1. Am. J. Physiol. Heart Circ. Physiol. 290 (2006) H416-H423