New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure

Journal of Perinatology

Volumn 26, Issue 2, 2006, Pages 93-99

  Attridge, J T ^a   Clark, R ^b   Walker, M W ^b,c   Gordon, P V ^a  

^a UNIVERSITY OF VIRGINIA CHILDREN S HOSPITAL   (United States)

^b PEDIATRIX MEDICAL GROUP   (United States)

^c GREENVILLE HOSPITAL SYSTEM   (United States)

Author keywords

Indomethacin; Intestinal perforation; Necrotizing enterocolitis; Neonate; Steroids

Indexed keywords

DEXAMETHASONE; HYDROCORTISONE; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GASTROINTESTINAL SURGERY; HUMAN; HYPOTHESIS; INTESTINE PERFORATION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NECROTIZING ENTEROCOLITIS; NEWBORN; PATENT DUCTUS ARTERIOSUS; PERINATAL DRUG EXPOSURE; PERINATAL PERIOD; PRENATAL CARE; RETROSPECTIVE STUDY; ANALYSIS OF VARIANCE; COMPARATIVE STUDY; FACTUAL DATABASE; FOLLOW UP; PREMATURITY; PREVALENCE; PROBABILITY; REGISTER; RISK ASSESSMENT; UNITED STATES;

ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COHORT STUDIES; DATABASES, FACTUAL; ENTEROCOLITIS, NECROTIZING; FEMALE; FOLLOW-UP STUDIES; HUMANS; INDOMETHACIN; INFANT, NEWBORN; INFANT, PREMATURE, DISEASES; INTESTINAL PERFORATION; MALE; MULTIVARIATE ANALYSIS; PREVALENCE; PROBABILITY; REGISTRIES; RETROSPECTIVE STUDIES; RISK ASSESSMENT; UNITED STATES;

EID: 33646092076     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/sj.jp.7211429     Document Type: Article

References (15)

1. Alpan G, Eyal F, Vinograd I, Udassin R, Amir G, Mogle P et al. Localized intestinal perforations after enteral administration of indomethacin in premature infants. J Pediatr 1985; 106: 277-281.
2. Aschner JL, Deluga KS, Metlay LA, Emmens RW, Hendricks-Munoz KD. Spontaneous focal gastrointestinal perforation in very low birth weight infants. J Pediatr 1988; 113: 364-367.
3. Scholz TD, McGuinness GA. Localized intestinal perforation following intravenous indomethacin for patent ductus arteriosus. J Pediatr Gastroenterol Nutr 1988; 7: 773-775.
4. Meyer CL, Payne NR, Roback SA. Spontaneous, isolated intestinal perforations in neonates with birth weight less than 1000 g not associated with necrotizing enterocolitis. J Pediatr Surg 1991; 26: 714-717.
5. Nagaraj HS, Sandhu AS, Cook LN, Buchino JJ, Groff DB. Gastrointestinal perforation following indomethacin therapy in very low birth weight infants. J Pediatr Surg 1981; 16: 1003-1007.
6. Schmidt B, Davis P, Moddemann D, Ohlsson A, Roberts RS, Saigal S et al. Long-term effects of indomethacin prophylaxis in extremely-low-birthweight infants. N Engl J Med 2001; 344: 1966-1972.
7. Stark AR, Carlo WA, Tyson JE, Papile LA, Wright LL, Shankaran S et al. Adverse effects of early dexamethasone in extremely-low birth-weight infants. National institute of child health and human development neonatal research network. N Engl J Med 2001; 344: 95-101.
8. Watterberg KL, Gerdes JS, Cole CH, Aucott SW, Thilo EH, Mammel MC et al. Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: A multicenter trial. Pediatrics 2004; 114: 1649-1657.
9. Guthrie SO, Gordon PV, Thomas V, Thorp JA, Peabody J, Clark RH. Necrotizing enterocolitis among neonates in the United States. J Perinatol 2003; 23: 278-285.
10. Fujii AM, Brown E, Mirochnick M, O'Brien S, Kaufman G. Neonatal necrotizzing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus. J Perinatol 2002; 22: 535-540.
11. Garland JS, Alex CP, Pauly TH, Whitehead VL, Brand J, Winston JF et al. A three-day course of dexamethasone therapy to prevent chronic lung disease in ventilated neonates: A randomized trial. Pediatrics 1999; 104: 91-99.
12. Vermont Oxford Network Steroid Study Group. Early postnatal dexamethasone therapy for the prevention of chronic lung disease. Pediatrics 2001; 108: 741-748.
13. Gordon P, Rutledge J, Sawin R, Thomas S, Woodrum D. Early postnatal dexamethasone increases the risk of focal small bowel perforation in extremely low birth weight infants. J Perinatol 1999; 19: 573-577.
14. Gordon PV, Young ML, Marshall DD. Focal small bowel perforation: An adverse effect of early postnatal dexamethasone therapy in extremely low birth weight infants. J Perinatol 2001; 21: 156-160.
15. Watterberg KL. Weighing statistical certainty against ethical, clinical, and biologic expediency: The contributions of the Watterberg trial tip the scales in the right direction: In reply. Pediatrics 2005; 115: 1447.