Tumour regression and mesorectal lymph node changes after intensified neoadjuvant chemoradiation for carcinoma of the rectum

APMIS

Volumn 114, Issue 3, 2006, Pages 201-210

  Prall, Friedrich ^a,b   Wöhlke, Michael ^a   Klautke, Gunther ^b   Schiffmann, Leif ^b   Fietkau, Rainer ^b   Barten, Malte ^a  

^a Institute of Pathology   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Mature dendritic cells; Mesorectal lymph nodes; Neoadjuvant chemoradiation; Rectal cancer

Indexed keywords

CAPECITABINE; CD4 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; CD83 ANTIGEN; FLUOROURACIL; IRINOTECAN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER STAGING; CD8+ T LYMPHOCYTE; CELL DENSITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; HELPER CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; RECTUM CARCINOMA; TUMOR IMMUNITY; TUMOR REGRESSION;

ADENOCARCINOMA; ANTIGENS, CD; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; DENDRITIC CELLS; DEOXYCYTIDINE; FEMALE; FLUOROURACIL; HUMANS; IMMUNOGLOBULINS; LYMPH NODES; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEOADJUVANT THERAPY; RECTAL NEOPLASMS;

EID: 33646088148     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2006.apm_304.x     Document Type: Article

References (25)

1. Kapiteijn E Marijnen CA Nagtegaal ID Putter H Steup WH Wiggers T et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. New Engl J Med 2001 345 638 46.
2. Sauer R Becker H Hohenberger W Rodel C Wittekind C Fietkau R et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. New Engl J Med 2004 351 1731 40.
3. Minsky BD. Adjuvant radiation therapy for rectal cancer: is there finally an answer? Lancet 2001 358 1285 6.
4. Titu LV Monson JR Greenman J. The role of CD8+ T cells in immune responses to colorectal cancer. Cancer Immunol Immunother 2002 51 235 74.
5. Banchereau J Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 245 52.
6. Whiteside TL Herberman RB. The role of natural killer cells in immune surveillance of cancer. Curr Opin Immunol 1995 7 704 10.
7. Klautke G Feyerherd P Ludwig K Prall F Foitzik T Fietkau R. Intensified concurrent chemoradiotherapy with 5-fluorouracil and irinotecan as neoadjuvant treatment in patients with locally advanced rectal cancer. Br J Cancer 2005 92 1215 20.
8. Sauter B Albert ML Francisco L Larsson M Somersan S Bhardwaj N. Consequences of cell death: exposure to necrotic tumor cells but not primary tissue cells or apoptotic cells induces the maturation of immunostimulatory dendritic cells. J Exp Med 2000 191 423 34.
9. Pihl E Nairn RC Milne BJ Cuthbertson AM Hughes ES Rollo A. Lymphoid hyperplasia. A major prognostic feature in 519 cases of colorectal carcinoma. Am J Pathol 1980 100 469 80.
10. Jass JR Atkin WS Cuzick J Bussey HJ Morson BC Northover JM et al. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology 1986 10 437 59.
11. Harrison JC Dean PJ El-Zeky F Vander Zwaag R. From Dukes through Jass: pathological indicators in rectal cancer. Hum Pathol 1994 25 498 505.
12. Naito Y Saito K Shiiba K Ohuchi A Saigenji K Nagura H et al. CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 1998 58 3491 4.
13. Prall F Dührkop T Weirich V Ostwald C Lenz P Nizze H et al. Prognostic role of CD8+ tumor-infiltrating lymphocytes in stage III colorectal cancer with and without microsatellite instability.. Hum Pathol 2004 35 808 18.
14. Huang FP Platt N Wykes M Major JR Powell TJ Jenkins CD et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med 2000 191 435 44.
15. Wichmann MW Meyer G Adam M Hochtlen-Vollmar W Angele MK Schalhorn A et al. Detrimental immunologic effects of preoperative chemoradiotherapy in advanced rectal cancer. Dis Colon Rectum 2003 46 875 87.
16. Koda K Saito N Oda K Seike K Kondo E Ishizuka M et al. Natural killer cell activity and distant metastasis in rectal cancers treated surgically with and without neoadjuvant chemoradiotherapy. J Am Coll Surg 2003 197 254 60.
17. Colorectal Cancer Collaborative Group. Adjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patients from 22 randomised trials. Lancet 2001 358 1291 304.
18. Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N Engl J Med 1997 336 980 7.
19. Douglass HO Jr. Moertel CG Mayer RF Thomas PR Lindblad AS Mittleman A et al. Survival after postoperative combination treatment of rectal cancer. N Engl J Med 1986 315 1294 5.
20. Krook JE Moertel CG Gunderson LL Wieand HS Collins RT Beart RW et al. Effective surgical adfuvant therapy for high-risk rectal carcinoma. N Engl J Med 1991 324 709 15.
21. NIH Consensus Conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA 1990 264 1444 50.
22. Petersen VC Baxter KJ Love SB Shepherd NA. Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer. Gut 2001 51 65 9.
23. Ueno H Murphy J Jass JR Mochizuki H Talbot IC. Tumour "budding" as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 2002 40 127 32.
24. Prall F Nizze H Barten M. Tumour budding as prognostic factor in stage I/II colorectal carcinoma. Histopathology 2005 47 17 24.
25. Bouzourene H Bosman FT Matter M Coucke P. Predictive factors in locally advanced rectal cancer treated with preoperative hyperfractionated and accelerated radiotherapy. Hum Pathol 2003 34 541 8.