A Single Administration of Testosterone Reduces Fear-Potentiated Startle in Humans

Biological Psychiatry

Volumn 59, Issue 9, 2006, Pages 872-874

  Hermans, Erno J ^a   Putman, Peter ^a   Baas, Johanna M ^a   Koppeschaar, Hans P ^b   van Honk, Jack ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

anxiety; benzodiazepines; fear; fear potentiated startle; startle reflex; Testosterone

Indexed keywords

TESTOSTERONE;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEAR; FEMALE; HUMAN; NORMAL HUMAN; PHYSIOLOGY; PRIORITY JOURNAL; STARTLE REFLEX; TIME SERIES ANALYSIS; TREATMENT DURATION; TREATMENT RESPONSE; VERBAL BEHAVIOR;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ANDROGENS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTROMYOGRAPHY; ELECTROSHOCK; FEAR; FEMALE; HUMANS; REACTION TIME; STARTLE REACTION; TESTOSTERONE;

EID: 33646080345     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.11.015     Document Type: Article

References (33)

1. Aikey J.L., Nyby J.G., Anmuth D.M., and James P.J. Testosterone rapidly reduces anxiety in male house mice (Mus musculus). Horm Behav 42 (2002) 448-460
2. Archer J. Risk-taking, fear, dominance, and testosterone. Behav Brain Sci 22 (1999) 214-215
3. Baas J.M., Grillon C., Böcker K.B., Brack A.A., Morgan III C.A., Kenemans J.L., et al. Benzodiazepines have no effect on fear-potentiated startle in humans. Psychopharmacology (Berl) 161 (2002) 233-247
4. Bing O., Heilig M., Kakoulidis P., Sundblad C., Wiklund L., and Eriksson E. High doses of testosterone increase anticonflict behaviour in rat. Eur Neuropsychopharmacol 8 (1998) 321-323
5. Bitran D., Kellogg C.K., and Hilvers R.J. Treatment with an anabolic-androgenic steroid affects anxiety-related behavior and alters the sensitivity of cortical GABAA receptors in the rat. Horm Behav 27 (1993) 568-583
6. Bitsios P., Philpott A., Langley R.W., Bradshaw C.M., and Szabadi E. Comparison of the effects of diazepam on the fear-potentiated startle reflex and the fear-inhibited light reflex in man. J Psychopharmacol 13 (1999) 226-234
7. Blumenthal T.D., Cuthbert B.N., Filion D.L., Hackley S., Lipp O.V., and van Boxtel A. Committee report. Guidelines for human startle eyeblink electromyographic studies. Psychophysiology 42 (2005) 1-15
8. Boissy A., and Bouissou M.F. Effects of androgen treatment on behavioral and physiological responses of heifers to fear-eliciting situations. Horm Behav 28 (1994) 66-83
9. Bouissou M.F., and Vandenheede M. Long-term effects of androgen treatment on fear reactions in ewes. Horm Behav 30 (1996) 93-99
10. Burris A.S., Banks S.M., Carter C.S., Davidson J.M., and Sherins R.J. A long-term, prospective study of the physiologic and behavioral effects of hormone replacement in untreated hypogonadal men. J Androl 13 (1992) 297-304
11. Campbell A. Staying alive. Evolution, culture, and women's intrasexual aggression. Behav Brain Sci 22 (1999) 203-214 discussion 214-252
12. Cooper M.A., and Ritchie E.C. Testosterone replacement therapy for anxiety. Am J Psychiatry 157 (2000) 1884
13. Davis M., Gendelman D.S., Tischler M.D., and Gendelman P.M. A primary acoustic startle circuit. Lesion and stimulation studies. J Neurosci 2 (1982) 791-805
14. Davis M., and Whalen P.J. The amygdala. Vigilance and emotion. Mol Psychiatry 6 (2001) 13-34
15. Edinger K.L., and Frye C.A. Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5alpha-reduced metabolites in the hippocampus. Psychoneuroendocrinology 30 (2005) 418-430
16. Fernandez-Guasti A., and Martinez-Mota L. Anxiolytic-like actions of testosterone in the burying behavior test. Role of androgen and GABA-benzodiazepine receptors. Psychoneuroendocrinology 30 (2005) 762-770
17. Frye C.A., and Seliga A.M. Testosterone increases analgesia, anxiolysis, and cognitive performance of male rats. Cogn Affect Behav Neurosci 1 (2001) 371-381
18. Graham S.J., Scaife J.C., Langley R.W., Bradshaw C.M., Szabadi E., Xi L., et al. Effects of lorazepam on fear-potentiated startle responses in man. J Psychopharmacol 19 (2005) 249-258
19. Grillon C. Startle reactivity and anxiety disorders. Aversive conditioning, context, and neurobiology. Biol Psychiatry 52 (2002) 958-975
20. Grillon C., Ameli R., Woods S.W., Merikangas K., and Davis M. Fear-potentiated startle in humans. Effects of anticipatory anxiety on the acoustic blink reflex. Psychophysiology 28 (1991) 588-595
21. Grillon C., Cordova J., Levine L.R., and Morgan III C.A. Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans. Psychopharmacology (Berl) 168 (2003) 446-454
22. Kasanin J., and Biskind G.R. Personality changes following substitution therapy in preadolescent eunuchoidism. JAMA 121 (1943) 1319-1321
23. Marks I.M. Fears, Phobias, and Rituals. Panic, Anxiety, and Their Disorders (1987), Oxford University Press, London
24. O'Connor D.B., Archer J., Hair W.M., and Wu F.C. Exogenous testosterone, aggression, and mood in eugonadal and hypogonadal men. Physiol Behav 75 (2002) 557-566
25. O'Connor D.B., Archer J., and Wu F.C. Effects of testosterone on mood, aggression, and sexual behavior in young men. A double-blind, placebo-controlled, cross-over study. J Clin Endocrinol Metab 89 (2004) 2837-2845
26. Pope Jr. H.G., Cohane G.H., Kanayama G., Siegel A.J., and Hudson J.I. Testosterone gel supplementation for men with refractory depression. A randomized, placebo-controlled trial. Am J Psychiatry 160 (2003) 105-111
27. Rosen J.B., and Schulkin J. From normal fear to pathological anxiety. Psychol Rev 105 (1998) 325-350
28. Scaife J.C., Langley R.W., Bradshaw C.M., and Szabadi E. Diazepam suppresses the acquisition but not the expression of 'fear-potentiation' of the acoustic startle response in man. J Psychopharmacol 19 (2005) 347-356
29. Shacham S. A shortened version of the Profile of Mood States. J Pers Assess 47 (1983) 305-306
30. Tuiten A., Van Honk J., Koppeschaar H., Bernaards C., Thijssen J., and Verbaten R. Time course of effects of testosterone administration on sexual arousal in women. Arch Gen Psychiatry 57 (2000) 149-153
31. Van Honk J., Peper J.S., and Schutter D.J. Testosterone reduces unconscious fear but not consciously experienced anxiety. Implications for the disorders of fear and anxiety. Biol Psychiatry 58 (2005) 218-225
32. Viau V., and Meaney M.J. The inhibitory effect of testosterone on hypothalamic-pituitary-adrenal responses to stress is mediated by the medial preoptic area. J Neurosci 16 (1996) 1866-1876
33. Wang C., Alexander G., Berman N., Salehian B., Davidson T., McDonald V., et al. Testosterone replacement therapy improves mood in hypogonadal men-a clinical research center study. J Clin Endocrinol Metab 81 (1996) 3578-3583