Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome

Cancer Genetics and Cytogenetics

Volumn 166, Issue 2, 2006, Pages 163-165

  Jekic, Biljana ^a   Novakovic, Ivana ^a   Lukovic, Ljiljana ^a   Kuzmanovic, Milos ^b   Popovic, Branka ^c   Milasin, Jelena ^c   Bunjevacki, Gordana ^b   Damnjanovic, Tatjana ^a   Cvjeticanin, Suzana ^a   Bunjevacki, Vera ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Institute for Mother and Child Health   (Serbia)

^c INSTITUTE FOR BASIC SCIENCE   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CODON; CONTROLLED STUDY; EXON; FEMALE; FMS GENE; GENE; GENE MUTATION; GENE SEQUENCE; HUMAN; MALE; MOLECULAR DYNAMICS; MYELODYSPLASTIC SYNDROME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; TP53 GENE;

EID: 33646073109     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2005.11.003     Document Type: Article

References (15)

1. Panizo C., Patino A., Lecumberri R., Calasanz M.J., Odero M.D., Bendandi M., and Rocha E. Secondary myelodysplastic syndrome after treatment for promyelocytic leukemia: clinical and genetic features of two cases. Cancer Genet Cytogenet 143 (2003) 178-181
2. Hofmann W.K., and Koeffler H.P. Important features of myelodysplastic syndrome. Int J Hematol 76 Suppl 2 (2002) 222-227
3. Jonveaux P., Fenaux P., Quiquandon I., Pignon J.M., Lai J.L., Loucheux-Lefebvre M.H., Goossens M., Bauters F., and Berger R. Mutations in the p53 gene in myelodysplastic syndromes. Oncogene 6 (1991) 2243-2247
4. Kaneko H., Misawa S., Horiike S., Nakai H., and Kashima K. TP53 mutations emerge at early phase of myelodysplastic syndrome and are associated with complex chromosomal abnormalities. Blood 85 (1995) 2189-2193
5. Sugimoto K., Hirano N., Toyoshima H., Chiba S., Mano H., Takaku F., Yazaki Y., and Hirai H. Mutations of the p53 gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia. Blood 81 (1993) 3022-3026
6. Baker A., Cachia P., Ridge S., McGlynn H., Clarke R., Whittaker J., Jacobs A., and Padua R.A. FMS mutations in patients following cytotoxic therapy for lymphoma. Leuk Res 19 (1995) 309-318
7. Tobal K., Pagliuca A., Bhatt B., Bailey N., Layton D.M., and Mufti G.J. Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 4 (1990) 486-489
8. Padua R.A., Guinn B.A., Al-Sabah A.I., Smith M., Taylor C., Pettersson T., Ridge S., Carter G., White D., Oscier D., Chevret S., and West R. RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-up. Leukemia 12 (1998) 887-892
9. Martinez-Ramirez A., Urioste M., Alvarez S., Vizmanos J.L., Calasanz M.J., Cigudosa J.C., and Benitez J. Cytogenetic profile of myelodysplastic syndromes with complex karyotypes: an analysis using spectral karyotyping. Cancer Genet Cytogenet 153 (2004) 39-47
10. Nakai H., Misawa S., Toguchida J., Yandell D.W., and Ishizaki K. Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p. Cancer Res 52 (1992) 6588-6593
11. Hollstein M., Sidransky D., Vogelstein B., and Harris C.C. p53 mutations in human cancers. Science 53 (1991) 49-53
12. Levine A.J., Momand J., and Finlay C.A. The p53 tumour suppressor gene. Nature 351 (1991) 453-456
13. Jekic B., Novakovic I., Lukovic L., Kuzmanovic M., Popovic B., Pastar I., Milasin J., Bunjevacki G., and Bunjevacki V. Low frequency of NRAS and KRAS gene mutations in childhood myelodysplastic syndromes. Cancer Genet Cytogenet 154 (2004) 180-182
14. Kikukawa M., Aoki N., and Mori M. A case of myelodysplastic syndrome with an intronic point mutation of the p53 tumor suppressor gene at the splice donor site. Br J Haematol 100 (1998) 564-566
15. Bueso-Ramos C.E., Yang Y., deLeon E., McCown P., Stass S.A., and Albitar M. The human MDM-2 oncogene is overexpressed in leukemias. Blood 82 (1993) 2617-2623