Editorial: Klinefelter's syndrome - A microcosm of male reproductive health

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 4, 2006, Pages 1220-1222

  Handelsman, David J ^a,b   Liu, Peter Y ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ANZAC RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN DEFICIENCY; AZOOSPERMIA; BREAST CANCER; CANCER MORTALITY; CHROMOSOME ANALYSIS; CLINICAL FEATURE; COHORT ANALYSIS; EDITORIAL; HODGKIN DISEASE; HUMAN; KARYOTYPE; KLINEFELTER SYNDROME; LIFE EXPECTANCY; LUNG CANCER; MALE INFERTILITY; MEN'S HEALTH; PRIORITY JOURNAL; PROSTATE CANCER; REPRODUCTIVE HEALTH; SPERMATOGENESIS; DENMARK; DISEASE COURSE; GENETIC LINKAGE; GENETICS; HEALTH; MALE; MORTALITY; NOTE; PATHOLOGY; PHYSIOLOGY; REPRODUCTION;

ANDROGEN;

ANDROGENS; DENMARK; DISEASE PROGRESSION; HEALTH; HUMANS; KLINEFELTER SYNDROME; LINKAGE (GENETICS); MALE; REPRODUCTION;

EID: 33646060757     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-0156     Document Type: Editorial

References (20)

1. Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E 2004 Klinefelter's syndrome. Lancet 364:273-283
2. Aksglaede L, Wikstrom AM, Rajpert-De Meyts E, Dunkel L, Skakkebaek NE, Juul A 2006 Natural history of seminiferous tubule degeneration in Klinefelter syndrome. Hum Reprod Update 12:39-48
3. Ratcliffe S 1999 Long-term outcome in children of sex chromosome abnormalities. Arch Dis Child 80:192-195
4. Bojesen A, Juul S, Gravholt CH 2003 Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study. J Clin Endocrinol Metab 88:622-626
5. Bojesen A, Juul S, Birkebaek N, Gravholt CH 2004 Increased mortality in Klinefelter syndrome. J Clin Endocrinol Metab 89:3830-3834
6. Swerdlow AJ, Schoemaker MJ, Higgins CD, Wright AF, Jacobs PA 2005 Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study. J Natl Cancer Inst 97:1204-1210
7. Swerdlow AJ, Higgins CD, Schoemaker MJ, Wright AF, Jacobs PA 2005 Mortality in patients with Klinefelter syndrome in Britain: a cohort study. J Clin Endocrinol Metab 90:6516-6522
8. Swerdlow AJ, Hermon C, Jacobs PA, Alberman E, Beral V, Daker M, Fordyce A, Youings S 2001 Mortality and cancer incidence in persons with numerical sex chromosome abnormalities: a cohort study. Ann Hum Genet 65:177-188
9. Bojeæn A, Juul S, Birkebæk NH, Gravholt CH 2006 Morbidity in Klinefelter syndrome: a Danish register study based on hospital discharge diagnoses. J Clin Endocrinol Metab 91:1254-1260
10. Abramsky L, Chapple J 1997 47, XXY (Klinefelter syndrome) and 47,XYY: estimated rates of and indication for postnatal diagnosis with implications for prenatal counselling. Prenat Diagn 17:363-368
11. Price WH, Clayton JF, Collyer S, de Mey R 1985 Mortality ratios and life expectancy in X chromatin positive males. J Epidemiol Community Health 39:33-38
12. Nieschlag E, Nieschlag S, Behre HM 1993 Lifespan and testosterone. Nature 366:215
13. Simpson JL, de la Cruz F, Swerdloff RS, Samango-Sprouse C, Skakkebaek NE, Graham Jr JM, Hassold T, Aylstock M, Meyer-Bahlburg HF, Willard HF, Hall JG, Salameh W, Boone K, Staessen C, Geschwind D, Giedd J, Dobs AS, Rogol A, Brinton B, Paulsen CA 2003 Klinefelter syndrome: expanding the phenotype and identifying new research directions. Genet Med 5:460-468
14. Aminorroaya A, Kelleher S, Conway AJ, Ly LP, Handelsman DJ 2005 Adequacy of androgen replacement influences bone density response to testosterone in androgen-deficient men. Eur J Endocrinol 152:881-886
15. Liu PY, Death AK, Handelsman DJ 2003 Androgens and cardiovascular disease. Endocr Rev 24:313-340
16. Handelsman DJ, Liu PY 2005 Andropause: invention, prevention, rejuvenation. Trends Endocrinol Metab 16:39-45
17. Liverman CT, Blazer DG, eds. 2004 Testosterone and aging: clinical research directions. Washington, DC: Institute of Medicine, The National Academies Press
18. Hasle H, Jacobsen BB, Asschenfeldt P, Andersen K 1992 Mediastinal germ cell tumour associated with Klinefelter syndrome. A report of case and review of the literature. Eur J Pediatr 151:735-739
19. Hasle H, Mellemgaard A, Nielsen J, Hansen J 1995 Cancer incidence in men with Klinefelter syndrome. Br J Cancer 71:416-420
20. Holden CA, McLachlan RI, Pitts M, Cumming R, Wittert G, Agius PA, Handelsman DJ, de Kretser DM 2005 Men in Australia Telephone Survey (MATeS): a national survey of the reproductive health and concerns of middle-aged and older Australian men. Lancet 366:218-224