NK1 antagonists based on seven membered lactam scaffolds

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 11, 2006, Pages 2929-2932

  Elliott, Jason M ^a   Carlson, Emma J ^a   Chicchi, Gary G ^b   Dirat, Olivier ^a   Dominguez, Maria ^a   Gerhard, Ute ^a   Jelley, Richard ^a   Jones, A Brian ^a   Kurtz, Marc M ^b   Tsao, Kwei lan ^b   Wheeldon, Alan ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Emesis; Lactam; NK1

Indexed keywords

NEUROKININ 1 RECEPTOR ANTAGONIST; TRIAZOLE DERIVATIVE; LACTAM; NEUROKININ 1 RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG IDENTIFICATION; EMBRYO; HUMAN; HUMAN CELL; METHYLATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM;

ANIMALIA;

CELL LINE; HUMANS; LACTAMS; MOLECULAR STRUCTURE; RECEPTORS, NEUROKININ-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646058539     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.080     Document Type: Article

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