A facile, KF/Al2O3 mediated method for the preparation of functionalized pyrido[2,3-d]pyrimidin-7(8H)-ones

Tetrahedron Letters

Volumn 47, Issue 18, 2006, Pages 3177-3180

  Blass, Benjamin E ^a   Coburn, Keith ^a   Fairweather, Neil ^a   Sabat, Mark ^a   West, Laura ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; ALUMINUM OXIDE; ESTER DERIVATIVE; FUNCTIONAL GROUP; POTASSIUM FLUORIDE; PYRIMIDINONE DERIVATIVE;

ARTICLE; POLYMERIZATION; SYNTHESIS;

EID: 33646033175     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.02.155     Document Type: Article

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28. 2, and the combined organic solvents are stripped to a solid. Purification by flash chromatography with 3/1 hexane/EtOAc on silica gel provided 131 mg (85%) of the desired product, 8-methyl-2-(methylthio)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-one.