Erectile potentials of a new phosphodiesterase type 5 inhibitor, DA-8159, in diet-induced obese rats

Asian Journal of Andrology

Volumn 8, Issue 3, 2006, Pages 325-329

  Yu, Jae Young ^a   Kang, Kyung Koo ^a   Yoo, Moohi ^a  

^a Dong A Pharmaceutical Company   (South Korea)

Author keywords

DA 8159; Intracavernous pressure; Obesity; Penile erection; Phosphodiesterase type 5 inhibitor

Indexed keywords

CHOLESTEROL; GLUCOSE; PHOSPHODIESTERASE V INHIBITOR; TRIACYLGLYCEROL; UDENAFIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET; DRUG EFFICACY; ELECTROSTIMULATION; ERECTILE DYSFUNCTION; GLUCOSE BLOOD LEVEL; MALE; NONHUMAN; OBESITY; PENIS ERECTION; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ANIMAL FEED; ANIMALS; DIET; IMPOTENCE; MALE; OBESITY; PENILE ERECTION; PHOSPHODIESTERASE INHIBITORS; PYRIMIDINES; RATS;

EID: 33646032996     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1111/j.1745-7262.2006.00136.x     Document Type: Article

References (20)

1. Ayta IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999; 84: 50-6.
2. Chung WS, Sohn JH, Park YY. Is obesity an underlying factor in erectile dysfunction? Eur Urol 1999; 36: 68-70.
3. Derby CA, Mohr BA, Goldstein I, Feldman HA, Johannes CB, McKinlay JB. Modifiable risk factors and erectile dysfunction: Can lifestyle changes modify risk? Urol 2000; 56: 302-6.
4. Shiri R, Koskimaki J, Hakama M, Hakkinen J, Huhtala H, Tammela TL, et al. Effect of life-style factors on incidence of erectile dysfunction. Int J Impot Res 2004; 16: 389-94.
5. Gunduz MI, Gumus BH, Sekuri C. Relationship between metabolic syndrome and erectile dysfunction. Asian J Androl 2004; 6: 355-8.
6. Kuan J, Brock G. Selective phosphodiesterase type 5 inhibition using tadalafil for the treatment of erectile dysfunction. Expert Opin Investig Drugs 2002; 11: 1605-13.
7. Padma-Nathan H, Paick JS, Ahn BO, Kang KK, Bahng MY, Kim WB. Phase 1, double-blind, placebo-controlled study in healthy male subjects to investigate the safety, tolerability, and pharmacokinetics of DA-8159. J Urol 2004; 171: S234.
8. Kang KK, Ahn GJ, Ahn BO, Yoo M, Kim WB. DA-8159, a new PDE5 inhibitor, induces penile erection in conscious and acute spinal cord injured rabbits. Eur Urol 2003; 43: 689-95.
9. Kang KK, Choi SM, Ahn GJ, Kwon JW, Kim WB. The effect of DA-8159 on corpus cavernosal smooth muscle relaxation and penile erection in diabetic rabbits. Urol Res 2004; 32: 107-11.
10. Levin BE, Triscari J, Sullivan AC. Relationship between sympathetic activity and diet-induced obesity in two rat strains. Am J Physiol 1983; 245: 364-71.
11. Lauterio TJ, Bond JP, Ulman EA. Development and characterization of a purified diet to identify obesity-susceptible and resistant rat populations. J Nutr 1994; 124: 2172-8.
12. Levin BE, Keesey RE. Defense of differing body weight set points in diet-induced obese and resistant rats. Am J Physiol 1998; 274 (2 Pt2): R412-9.
13. Levin BE, Dunn-Meynell AA. Defense of body weight against chronic caloric restriction in obesity-prone and -resistant rats. Am J Physiol Regul Integr Comp Physiol 2000; 278: R231-7.
14. Levin BE, Hogan S, Sullivan AC. Initiation and perpetuation of obesity and obesity resistance in rats. Am J Physiol 1989; 256 (3 Pt1): R766-71.
15. Jung R. Endocrinological aspects of obesity. Clin Endocrinol Metab 1984; 13: 579-612.
16. Esposito K, Giugliano D. Obesity, the metabolic syndrome, and sexual dysfunction. Int J Impot Res 2005; 17: 391-8.
17. Dobrian AD, Davies MJ, Prewitt RL, Lauterio TJ. Development of hypertension in a rat model of diet-induced obesity. Hypertension 2000; 35: 1009-15.
18. Wei M, Macera CA, Davis DR, Hornung CA, Nankin HR, Blair SN. Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction. Am J Epidemiol 1994; 140: 930-7.
19. Gemalmaz H, Waldeck K, Chapman TN, Tuttle JB, Steers WD, Andersson KE. In vivo and in vitro investigation of the effects of sildenafil on rat cavernous smooth muscle. J Urol 2001; 165: 1010-4.
20. Angulo J, Bischoff E, Gabancho S, Cuevas, P, Saenz de Tejada, I. Vardenafil reverses erectile dysfunction induced by paroxetine in rats. Int J Impot Res 2003; 15: 90-3.