Genome-wide analysis of deoxyribonucleic acid in endometrial cancer using comparative genomic hybridization microarrays

International Journal of Gynecological Cancer

Volumn 16, Issue 2, 2006, Pages 834-842

  O'Toole, S A ^a   Dunn, E ^a   Sheppard, B L ^a   Klocker, H ^b   Bektic, J ^b   Smyth, P ^c   Martin, C ^c   Sheils, O ^c   O'Leary, J J ^c  

^a ST JAMES S HOSPITAL   (Ireland)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Array CGH; Endometrium; Oncogene

Indexed keywords

ANDROGEN RECEPTOR; DNA; FIBROBLAST GROWTH FACTOR 3; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR RECEPTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; SCATTER FACTOR RECEPTOR;

ADENOSQUAMOUS CARCINOMA; ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CARCINOGENESIS; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DNA MICROARRAY; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CANCER; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LEIOMYOSARCOMA; MENOPAUSE; MIXED MULLERIAN TUMOR; MUCINOUS CARCINOMA; ONCOGENE; ONCOGENE H RAS; ONCOGENE MYC; ONCOGENE N RAS; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RNA EXTRACTION; SEROUS PAPILLARY ADENOCARCINOMA; STATISTICAL ANALYSIS;

ADENOCARCINOMA; ADENOCARCINOMA, PAPILLARY; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, ADENOSQUAMOUS; CASE-CONTROL STUDIES; CYSTADENOCARCINOMA, SEROUS; DNA; DNA, NEOPLASM; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENES; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 33646032742     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2006.00530.x     Document Type: Article

References (46)

1. Parkin DM Pisani P Ferlay J Estimates of the worldwide incidence of twenty-five major cancers in 1990 Int J Cancer 1999 80 827 41
2. National Cancer Registry Ireland 1998-2001 Available at
3. Malkasian GD Jr. Carcinoma of the endometrium: effect of stage and grade on survival Cancer 1978 41 996 1001
4. Connelly PJ Alberhasky RC Christopherson WM Carcinoma of the endometrium. III. Analysis of 865 cases of adenocarcinoma and adenoacanthoma Obstet Gynecol 1982 59 569 75
5. Coleman MP Babb P Damiecki P et al Cancer survival trends in England and Wales 1971-1995. Deprivation and NHS Region In Studies in medical and population subjects No. 61 London The Stationery Stores Publications Center 1999 355 84
6. Bokhman JV Two pathogenetic types of endometrial carcinoma Gynecol Oncol 1983 15 10 7
7. Lax SF Kendall B Tashiro H Slebos RJ Hedrick L The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways Cancer 2000 88 814 24
8. Horvath G Leser G Hahlin M Henriksson M Exon deletions and variants of human estrogen receptor mRNA in endometrial hyperplasia and adenocarcinoma Int J Gynecol Cancer 2000 10 128 36
9. De Vivo I Huggins GS Hankinson SE et al A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk Proc Natl Acad Sci U S A 2002 99 12263 8
10. Matias-Guiu X Catasus L Bussaglia E et al Molecular pathology of endometrial hyperplasia and carcinoma Hum Pathol 2001 32 569 77
11. Kallioniemi A Kallioniemi OP Sudar D et al Comparative genomic hybridization for molecular cytogenetic analysis of solid tumor Science 1992 258 818 21
12. du Manoir S Schrock E Bentz M et al Quantitative analysis of comparative genomic hybridization Cytometry 1995 19 27 41
13. Solinas-Toldo S Lampel S Stilgenbauer S et al Matrix-based comparative genomic hybridization: biochips to screen for genomic imbalances Genes Chromosomes Cancer 1997 20 399 407
14. Pinkel D Segraves R Sudar D et al High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays Nat Genet 1998 20 207 11
15. Albertson DG Ylstra B Segraves R et al Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene Nat Genet 2000 25 144 6
16. Miller N Bedard YC Cooter NB Shaul DL Histological changes in the genital tract in transsexual women following androgen therapy Histopathology 1986 10 661 9
17. Futterweit W Deligdisch L Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals J Clin Endocrinol Metab 1986 62 16 21
18. Maia H Jr. Maltez A Fahel P Athayde C Coutinho E Detection of testosterone and estrogen receptors in the postmenopausal endometrium Maturitas 2001 38 179 88
19. Taylor AH Guzail M Wahab M Thompson JR Al-Azzawi F Quantitative histomorphometric analysis of gonadal steroid receptor distribution in the normal human endometrium through the menstrual cycle Histochem Cell Biol 2005 123 4-5 463 74
20. Shayesteh L Lu Y Kuo WL et al PIK3CA is implicated as an oncogene in ovarian cancer Nat Genet 1999 21 99 102
21. Pere H Tapper J Wahlstrom T Knuutila S Butzow R Distinct chromosomal imbalances in uterine serous and endometrioid carcinomas Cancer Res 1998 58 892 5
22. Shayesteh L Lu Y Kuo WL et al PIK3CA is implicated as an oncogene in ovarian cancer Nat Genet 1999 21 99 102
23. Massion PP Kuo WL Stokoe D et al Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway Cancer Res 2002 62 3636 40
24. Hui AB Lo KW Teo PM To KF Huang DP Genome wide detection of oncogene amplifications in nasopharyngeal carcinoma by array based comparative genomic hybridization Int J Oncol 2002 20 467 73
25. Redon R Muller D Caulee K Wanherdrick K Abecassis J du Manoir S A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains Cancer Res 2001 61 4122 9
26. Estilo CL O-Charoenrat P Ngai I et al The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue Clin Cancer Res 2003 9 2300 6
27. Hui AB Lo KW Yin XL Poon WS Ng HK Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization Lab Invest 2001 81 717 23
28. Ma YY Wei SJ Lin YC et al PIK3CA as an oncogene in cervical cancer Oncogene 2000 19 2739 44
29. Nelson P Kiriakidou M Sharma A Maniataki E Mourelatos Z The microRNA world: small is mighty Trends Biochem Sci 2003 28 534 40
30. Castoria G Lombardi M Barone MV Rapid signalling pathway activation by androgens in epithelial and stromal cells Steroids 2004 69 517 22
31. Bottaro DP Rubin JS Faletto DL et al Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product Science 1991 251 802 4
32. Bussolino F Di Renzo MF Ziche M et al Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth J Cell Biol 1992 119 629 41
33. Stoker M Gherardi E Perryman M Gray J Scatter factor is a fibroblast-derived modulator of epithelial cell mobility Nature 1987 327 239 42
34. Nakamura T Teramoto H Ichihara A Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures Proc Natl Acad Sci U S A 1986 83 6489 93
35. Rubin JS Chan AM Bottaro DP et al A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor Proc Natl Acad Sci U S A 1991 88 415 9
36. Weidner KM Behrens J Vandekerckhove J Birchmeier W Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells J Cell Biol 1990 111 2097 108
37. Jeffers M Rong S Vande Woude GF Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network Mol Cell Biol 1996 16 1115 25
38. Montesano R Matsumoto K Nakamura T Orci L Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor Cell 1991 67 901 8
39. Brinkmann V Foroutan H Sachs M Weidner KM Birchmeier W Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells J Cell Biol 1995 131 1573 86
40. Negami A Sasaki H Kawakami Y et al Serum human hepatocyte growth factor in human menstrual cycle and pregnancy: a novel serum marker of regeneration and reconstruction of human endometrium Horm Res 1995 44 42 6
41. Wagatsuma S Konno R Sato S Yajima A Tumor angiogenesis, hepatocyte growth factor, and c-Met expression in endometrial carcinoma Cancer 1998 82 520 30
42. Sonoda G du Manoir S Godwin AK et al Detection of DNA gains and losses in primary endometrial carcinomas by comparative genomic hybridization Genes Chromosomes Cancer 1997 18 115 25
43. Micci F Teixeira MR Haugom L Kristensen G Abeler VM Heim S Genomic aberrations in carcinomas of the uterine corpus Genes Chromosomes Cancer 2004 40 229 46
44. Salvesen HB Akslen LA Molecular pathogenesis and prognostic factors in endometrial carcinoma APMIS 2002 110 673 89
45. Garnis C Campbell J Zhang L Rosin MP Lam WL OCGR array: an oral cancer genomic regional array for comparative genomic hybridization analysis Oral Oncol 2004 40 511 9
46. Holzmann K Kohlhammer H Schwaenen C et al Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes Cancer Res 2004 64 4428 33