Exon deletions and variants of human estrogen receptor mRNA in endometrial hyperplasia and adenocarcinoma

International Journal of Gynecological Cancer

Volumn 10, Issue 2, 2000, Pages 128-136

  Horvath, G ^a   Leser, G ^a   Hahlin, M ^a   Henriksson, M ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; MESSENGER RNA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; EXON; FEMALE; GENE DELETION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0034034197     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1438.2000.00009.x     Document Type: Article

References (21)

1. McDonald TW, Malkasian GD, Gaffey TA. Endometrial cancer associated with feminizing ovarian tumor and polycystic ovarian disease. Obstet Gynecol 1977;49:654-8.
2. Baker VV. The molecular biology of endometrial adenocarcinoma. Clin Obstet Gynecol 1996;39:707-15.
3. van Leeuwen FE, Benraadt J, Coebergh JW et al. Risk of endometrial cancer after tamoxifen treatment of breast cancer [see comments]. Lancet 1994;343:448-52.
4. Beato M. Gene regulation by steroid hormones. Cell 1989;56:335-44.
5. Kumar V, Green S, Stack G, Berry M, Jin JR, Chambon P. Functional domains of the human estrogen receptor. Cell 1987;51:941-51.
6. Wang Y, Miksicek RJ. Identification of a dominant negative form of the human estrogen receptor. Mol Endocrinol 1991;5:1707-15.
7. Fuqua SA, Chamness GC, McGuire WL. Estrogen receptor mutations in breast cancer. J Cell Biochem 1993;51: 135-9.
8. Gotteland M, May E, May-Levin F, Contesso G, Delarue JC, Mouriesse H. Estrogen receptors (ER) in human breast cancer. The significance of a new prognostic factor based on both ER protein and ER mRNA contents. Cancer 1994;74:864-71.
9. Gotteland M, Desauty G, Delarue JC, Liu L, May E. Human estrogen receptor messenger RNA variants in both normal and tumor breast tissues. Mol Cell Endocrinol 1995;112:1-13.
10. Rice WL, Jazaeri AA, Shupnik MA. Estrogen receptor mRNA splice variants in pre- and postmenopausal human endometriam and endometrial carcinoma. Gynecol Oncol 1997;65:149-57.
11. Daffada AA, Dowsett M. Tissue-dependent expression of a novel splice variant of the human oestrogen receptor. J Steroid Biochem Mol Biol 1995;55:413-21.
12. Zhang QX, Hilsenbeck SG, Fuqua AW, Borg Å. Multiple splicing variants of the estrogen receptor are present in individual human breast tumors. J Steroid Biochem Molec Biol 1996;59:251-60.
13. Green S, Walter P, Greene G et al. Cloning of the human oestrogen receptor cDNA. J Steroid Biochem 1986;24:77-83.
14. Raam S, Robert N, Pappas CA, Tamura H. Defective estrogen receptors in human mammary cancers: their significance in defining hormone dependence. J Natl Cancer Inst 1988;80:756-61.
15. Fuqua SA, Fitzgerald SD, Allred DC et al. Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Res 1992;52:483-6.
16. Andersson C, Forsberg JG. Induction of estrogen receptor, peroxidase activity, and epithelial abnormalities in the mouse uterovaginal epithelium after neonatal treatment with diethylstilbestrol. Teratog Carcinog Mutagen 1988;8:347-61.
17. Castles CG, Fuqua SA, Klotz DM, Hill SM. Expression of a constitutively active estrogen receptor variant in the estrogen receptor-negative BT-20 human breast cancer cell line. Cancer Res 1993;53:5934-9.
18. Leygue E, Huang A, Murphy LC, Watson PH. Prevalence of estrogen receptor variant messenger RNAs in human breast cancer. Cancer Res 1996;56:4324-7.
19. Madsen MW, Reiter BE, Lykkesfeldt AE. Differential expression of estrogen receptor mRNA splice variants in the tamoxifen resistant human breast cancer cell line, MCF-7/TAMR-1 compared to the parental MCF-7 cell line. Mol Cell Endocrinol 1995;109:197-207.
20. Horwitz KB, McGuire WL. Specific progesterone receptors in human breast cancer. Steroids 1975;25:497-505.
21. Scott GK, Kushner P, Vigne JL, Benz CC. Truncated forms of DNA-binding estrogen receptors in human breast cancer. J Clin Invest 1991;88:700-6.