Cytokines in aging and exercise

International Journal of Sports Medicine, Supplement

Volumn 21, Issue 1, 2000, Pages

  Pedersen, Bente Klarlund ^a   Bruunsgaard, H ^a   Ostrowski, K ^a   Krabbe, K ^a   Hansen, H ^a   Krzywkowski, K ^a   Toft, A ^a   Sondergaard S R ^a   Petersen, E W ^a   Ibfelt, T ^a   Schjerling, P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CHEMOKINE; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ACUTE PHASE RESPONSE; AGING; ARTICLE; ATHEROSCLEROSIS; BLOOD LEVEL; BLOOD PRESSURE; CORRELATION FUNCTION; CYTOKINE RELEASE; DEMENTIA; EXERCISE; HUMAN; INFECTION;

ADULT; AGED; AGED, 80 AND OVER; AGING; CYTOKINES; DISEASE SUSCEPTIBILITY; EXERCISE; HUMANS; INFECTION; MIDDLE AGED; MODELS, IMMUNOLOGICAL; WOUNDS AND INJURIES;

EID: 0034034678     PISSN: 0943917X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Bagby GJ, Crouch LD, Shepherd RE. Exercise and cytokines: Spontaneous and elicited responses. In: Hoffman-Goetz L (ed). Exercise and Immune Function. New York: CRC Press, 1996: 55
2. Bosenberg AT, Brock Utne JG, Gaffin SL, Wells MT, Blake GT. Strenuous exercise causes systemic endotoxemia. J Appl Physiol 1988; 65: 106-108
3. Brock Utne JG, Gaffin SL, Wells MT, Gathiram P, Sohar E, James MF, Morrell DF, Norman RJ. Endotoxemia in exhausted runners after a long-distance race. S Afr Med J 1988; 73: 533-536
4. Bruunsgaard H, Andersen-Ranberg K, Jeune B, Pedersen AN, Skinhj P, Pedersen BK. A high plasma concentration of TNF-α is associated with dementia in centenarians. J Gerontology 1999; 54 (7): 357-364
5. Bruunsgaard H, Galbo H, Halkjaer-Kristensen J, Johansen TL, Mac Lean DA, Pedersen BK. Exercise-induced increase in interleukin-6 is related to muscle damage. J Physiol Lond 1997; 499: 833-841
6. Bruunsgaard H, Skinhoj P, Qvist J, Pedersen BK. Elderly human show prolonged in vivo inflammatory activity during pneumococcal infections. J Inf Dis 1999; 180 (2): 551-554
7. Cannon JG, Evans WJ, Hughes VA, Meredith CN, Dinarello CA. Physiological mechanisms contributing to increased interleukin-1 secretion. J Appl Physiol 1986; 61: 1869-1874
8. Cannon JG, Kluger MJ. Endogenous pyrogen activity in humans plasma after exercise. Science 1983; 220: 617-619
9. Castell LM, Poortmans JR, Leclercq R, Brasseur M, Duchateau J, Newsholme EA. Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. Eur J Appl Physiol 1997; 75: 47-53
10. Catania A, Airagi L, Motta P, Manfredi MG, Annoni G, Pettenati C, Brambilla F, Lipton JM. Cytokine antagonists in aged subjets and their relation with cellular immunity. J Gerontol A Biol Sci Med Sci 1997; 52: B93-B97
11. Croisier JL, Camus G, Venneman I, Deby-Dupont G, Juchmes-Ferir A, Lamy M, Crielaard JM, Deby C, Duchateau J. Effects of training on execise-induced muscle damage and interleukin 6 production. Muscle Nerve 1999; 22: 208-212
12. DeRijk RH, Boelen A, Tilders FJ, Berkenbosch F. Induction of plasma interleukin-6 by circulating adrenaline in the rat. Psychoneuroendocrinology 1994; 19: 155-163
13. Dinarello CA. Role of interleukin-1 in infectious diseases. Immunol Rev 1992; 127: 119-146
14. Drenth JP, van Uum SH, van Deuren M, Pesman GJ, van der ven Jongekrug J, van der Meer JW. Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-α and IL-1β production. J Appl Physiol 1995; 79: 1497-1503
15. Ershler WB, Sun WH, Binkley N, Gravenstein S, Volk MJ, Kamoske G, Klopp RG, Roecker EB, Daynes RA, Weindruch R. Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production in modifiable by dietary restriction. Lymphokine Cytokine Res 1993; 12: 225-230
16. Evans WJ, Meredith CN, Cannon JG, Dinarello CA, Frontera WR, Hughes VA, Jones BH, Knuttgen HG. Metabolic changes following eccentric exercise in trained and untrained men. J Appl Physiol 1986; 61: 1864-1868
17. Hellsten Y, Frandsen U, Orthenblad N, Sjodin N, Richter EA. Xanthine oxidase in human skeletal muscle following eccentric exercise: a role of inflammation. J Physiol (London) 1997; 498: 239-248
18. Kania DM, Binkley N, Checovich M, Havighurst T, Schilling M, Ershler WB. Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density. J Am Geriatr Soc 1995; 43: 236-239
19. Klausen T, Richalet JP, Olsen NV, Pedersen BK. Hypoxemia increases serum interleukin-6 in humans. Eur J Appl Physiol 1997; 76: 480-482
20. Martin C, Boisson C, Haccoun M, Thomacot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor-a and interleukin-6) after septic shock, and severe trauma. Crit Care Med 1997; 25: 1813-1819
21. Moore GE, Holbein ME, Knochel JP. Exercise-associated collapse in cyclists is unrelated to endotoxemia. Med Sci Sports Exerc 1995; 27: 1238-1242
22. Nehlsen Cannarella SL, Fagoaga OR, Nieman DC, Henson DA, Butterworth DE, Schmitt RL, Bailey EM, Warren BJ, Utter A, Davis JM. Carbohydrate and the cytokine response to 2.5 h of running. J Appl Physiol 1997; 82: 1662-1667
23. Nielsen SV, Henrichsen J. Incidence of invasive pneumococcal disease and distribution of capsular types of pneumococci in Denmark. Epidemiology and Infection 1996; 117: 411-416
24. Northoff H, Berg A. Immunologic mediators as parameters of the reaction to strenuous exercise. Int J Sports Med 1991; 12: S9-S15
25. Ostrowski K, Hermann C, Bangash A, Schjerling P, Nielsen JN, Pedersen BK. A trauma-like elevation in plasma cytokines in humans in response to treadmill running. J Physiol (London) 1998; 508: 949-953
26. Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. The cytokine balance and strenuous exercise: TNF-α, IL-2β, IL-6, IL-1ra, sTNF-r1, sTNF-r2, and IL-10. J Physiol (London) 1999; 515: 287-291
27. Ostrowski K, Rohde T, Zacho M, Asp S, Pedersen BK. Evidence that IL-6 is produced in skeletal muscle during intense long-term muscle activity. J Physiol (London) 1998; 508: 949-953
28. Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H. The cytokine response to strenuous exercise. Can J Physiol Pharmacol 1998; 76: 505-511
29. Richards C, Gauldie J. Role of cytokines in acute-phase response. In: Aggarwal BB, Puri RK (eds). Human Cytokines: Their roles in disease and therapy. Cambridge, Massachusetts, USA: Blackwell Science, 1995: 253
30. Rohde T, McLean DA, Richter EA, Kiens B, Pedersen BK. Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6. Am J Physiol 1997; 273: E85-E91
31. Ross R. Atherosclerosis-An inflammatory disease. New Engl J Med 1999; 340: 115-126
32. Sprenger H, Jacobs C, Nain M, Gressner AM, Prinz H, Wesemann W, Gemsa D. Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. Clin Immunol Immunopathol 1992; 63: 188-195
33. Torres JM, Cardenas O, Vasquez A, Schlossberg D. Streptococcus pneumoniae bacteremia in a community hospital. Chest 1998; 113: 387-390
34. Ullum H, Haahr PM, Diamant M, Palmo J, Halkjaer-Kristensen J, Pedersen BK. Bicycle exercise enhances plasma IL-6 but does not change IL-1α, IL-1β, IL-6, or TNFα pre-mRNA in BMNC. J Appl Physiol 1994; 77: 93-97
35. Vandenabeele P, Fiers W. Is amyloidogenesis during Alzheimer's disease due to an IL-1/1L-6 mediated 'acute phase response' in the brain? Immunology Today 1991; 12: 217-219
36. Waage A, Halstensen A, Shalaby R, Brandtæg P, Kierullf P, Espevik T. Local production of tumour necrosis factor-α, interleukin 1, and interleukin 6 in meningococcal meningitis. J Exp Med 1989; 170: 1859-1867
37. Wei J, Xu H, Davies JL, Hemmings GP. Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci 1992; 51: 1953-1956