The fragile X-cerebellum connection

Trends in Neurosciences

Volumn 29, Issue 4, 2006, Pages 183-185

  Huber, Kimberly M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; METABOTROPIC RECEPTOR;

CEREBELLUM; DEPOLARIZATION; FRAGILE X SYNDROME; GENE FUNCTION; HUMAN; KNOCKOUT MOUSE; LEARNING DISORDER; LONG TERM DEPRESSION; MENTAL DEFICIENCY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; SHORT SURVEY; STEADY STATE; SYNAPSE;

ANIMALS; ASSOCIATION LEARNING; CEREBELLUM; CONDITIONING, EYELID; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; HUMANS; MICE; MICE, KNOCKOUT; SYNAPSES;

EID: 33646001722     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2006.02.001     Document Type: Short Survey

References (15)

1. O'Donnell W.T., and Warren S.T. A decade of molecular studies of fragile X syndrome. Annu. Rev. Neurosci. 25 (2002) 315-338
2. The Dutch-Belgian Fragile X Consortium. Fmr1 knockout mice: a model to study fragile X mental retardation. Cell 78 (1994) 23-33
3. Chen L., and Toth M. Fragile X mice develop sensory hyperreactivity to auditory stimuli. Neuroscience 103 (2001) 1043-1050
4. Dobkin C., et al. Fmr1 knockout mouse has a distinctive strain-specific learning impairment. Neuroscience 100 (2000) 423-429
5. Paradee W., et al. Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function. Neuroscience 94 (1999) 185-192
6. Koekkoek S.K., et al. Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron 47 (2005) 339-352
7. Medina J.F., et al. Mechanisms of cerebellar learning suggested by eyelid conditioning. Curr. Opin. Neurobiol. 10 (2000) 717-724
8. Bagni C., and Greenough W.T. From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nat. Rev. Neurosci. 6 (2005) 376-387
9. Jin P., et al. RNA and microRNAs in fragile X mental retardation. Nat. Cell Biol. 6 (2004) 1048-1053
10. Antar L.N., and Bassell G.J. Sunrise at the synapse: the FMRP mRNP shaping the synaptic interface. Neuron 37 (2003) 555-558
11. Weiler I.J., et al. Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 5395-5400
12. Huber K.M., et al. Altered synaptic plasticity in a mouse model of fragile-X mental retardation. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 7746-7750
13. Bear M.F., et al. The mGluR theory of fragile X mental retardation. Trends Neurosci. 27 (2004) 370-377
14. Karachot L., et al. Induction of long-term depression in cerebellar Purkinje cells requires a rapidly turned over protein. J. Neurophysiol. 86 (2001) 280-289
15. Aizenman C.D., and Linden D.J. Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. J. Neurophysiol. 82 (1999) 1697-1709