Epstein-Barr viremia levels after pediatric liver transplantation as measured by real-time polymerase chain reaction

Pediatric Transplantation

Volumn 10, Issue 1, 2006, Pages 83-89

  Kullberg Lindh, Carola ^a   Ascher, Henry ^a   Saalman, Robert ^a   Olausson, Michael ^b   Lindh, Magnus ^c  

^a QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Epstein Barr virus; Pediatric liver transplantation; Post transplant lymphoproliferative disorder; Real time PCR

Indexed keywords

ANTIVIRUS AGENT; AZATHIOPRINE; CIDOFOVIR; CYCLOSPORIN A; CYTOMEGALOVIRUS ANTIBODY; GANCICLOVIR; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PREDNISOLONE; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY; VIRUS DNA;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; DIAGNOSTIC VALUE; DRUG EFFICACY; EPSTEIN BARR VIRUS; FEMALE; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFANT; INFECTION PREVENTION; LIVER TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; MALE; NONHUMAN; PEDIATRICS; POSTOPERATIVE COMPLICATION; PRECANCER; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; RISK FACTOR; SWEDEN; SYMPTOMATOLOGY; VIREMIA; VIRUS INFECTION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DNA, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; INFANT; LIVER DISEASES; LIVER TRANSPLANTATION; MALE; POLYMERASE CHAIN REACTION; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; RETROSPECTIVE STUDIES; VIREMIA;

EID: 33645996356     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2005.00404.x     Document Type: Article

References (24)

1. H o M J affe R M iller G et al. The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation and its manifestations in children Transplantation 1988 45 719 727
2. M anez R B reinig MC L inden P et al. Posttransplant lymphoproliferative disease in primary Epstein-Barr virus infection after liver transplantation: the role of cytomegalovirus disease J Infect Dis 1997 176 1462 1467
3. H urwitz M D esai DM C ox KL B erquist WE E squivel CO M illan MT Complete immunosuppressive withdrawal as a uniform approach to post-transplant lymphoproliferative disease in pediatric liver transplantation Pediatr Transplant 2004 8 267 272
4. M c D iarmid SV J ordan S K im GS et al. Prevention and preemptive therapy of posttransplant lymphoproliferative disease in pediatric liver recipients Transplantation 1998 66 1604 1611
5. C ollins MH M ontone KT L eahey AM et al. Post-transplant lymphoproliferative disease in children Pediatr Transplant 2001 5 250 257
6. C acciarelli TV R eyes J J affe R et al. Primary tacrolimus (FK506) therapy and the long-term risk of post-transplant lymphoproliferative disease in pediatric liver transplant recipients Pediatr Transplant 2001 5 359 364
7. B odeus M S mets F R eding R et al. Epstein-Barr virus infection in sixty pediatric liver graft recipients: diagnosis of primary infection and virologic follow-up Pediatr Infect Dis J 1999 18 698 702
8. N ewell KA A lonso EM W hitington PF et al. Posttransplant lymphoproliferative disease in pediatric liver transplantation. Interplay between primary Epstein-Barr virus infection and immunosuppression Transplantation 1996 62 370 375
9. S mets F B odeus M G oubau P et al. Characteristics of Epstein-Barr virus primary infection in pediatric liver transplant recipients J Hepatol 2000 32 100 104
10. A vitzur Y D e L uca E C antos M et al. Health status ten years after pediatric liver transplantation-looking beyond the graft Transplantation 2004 78 566 573
11. N iesters HG van E sser J F ries E W olthers KC C ornelissen J O sterhaus AD Development of a real-time quantitative assay for detection of Epstein-Barr virus J Clin Microbiol 2000 38 712 715
12. R owe DT Q u L R eyes J et al. Use of quantitative competitive PCR to measure Epstein-Barr virus genome load in the peripheral blood of pediatric transplant patients with lymphoproliferative disorders J Clin Microbiol 1997 35 1612 1615
13. W agner HJ J abs W S mets F et al. Real-time polymerase chain reaction (RQ-PCR) for the monitoring of Epstein-Barr virus (EBV) load in peripheral blood mononuclear cells Klin Padiatr 2000 212 206 210
14. K ullberg -L indh C A scher H K rantz M L indh M Quantitative analysis of CMV DNA in children the first year after liver transplantation Pediatr Transplant 2003 7 296 301
15. K ogan -L iberman D B urroughs M E mre S M oscona A S hneider BL The role of quantitative Epstein-Barr virus polymerase chain reaction and preemptive immunosuppression reduction in pediatric liver transplantation: a preliminary experience J Pediatr Gastroenterol Nutr 2001 33 445 449
16. Y ounes BS A ment ME M c D iarmid SV M artin MG V argas JH The involvement of the gastrointestinal tract in posttransplant lymphoproliferative disease in pediatric liver transplantation J Pediatr Gastroenterol Nutr 1999 28 380 385
17. C ao S C ox K E squivel CO et al. Posttransplant lymphoproliferative disorders and gastrointestinal manifestations of Epstein-Barr virus infection in children following liver transplantation Transplantation 1998 66 851 856
18. C ox KL L awrence -M iyasaki LS G arcia -K ennedy R et al. An increased incidence of Epstein-Barr virus infection and lymphoproliferative disorder in young children on FK506 after liver transplantation Transplantation 1995 59 524 529
19. M atsukura T Y okoi A E gawa H et al. Significance of serial real-time PCR monitoring of EBV genome load in living donor liver transplantation Clin Transplant 2002 16 107 112
20. C ampe H J aeger G A bou -A jram C et al. Serial detection of Epstein-Barr virus DNA in sera and peripheral blood leukocyte samples of pediatric renal allograft recipients with persistent mononucleosis-like symptoms defines patients at risk to develop post-transplant lymphoproliferative disease Pediatr Transplant 2003 7 46 52
21. O rii T O hkohchi N K ikuchi H et al. Usefulness of quantitative real-time polymerase chain reaction in following up patients with Epstein-Barr virus infection after liver transplantation Clin Transplant 2000 14 308 317
22. B rengel -P esce K M orand P S chmuck A et al. Routine use of real-time quantitative PCR for laboratory diagnosis of Epstein-Barr virus infections J Med Virol 2002 66 360 369
23. R ose C G reen M W ebber S E llis D R eyes J R owe D Pediatric solid-organ transplant recipients carry chronic loads of Epstein-Barr virus exclusively in the immunoglobulin D-negative B-cell compartment J Clin Microbiol 2001 39 1407 1415
24. H olmes RD S okol RJ Epstein-Barr virus and post-transplant lymphoproliferative disease Pediatr Transplant 2002 6 456 464