Expression of human soluble complement receptor 1 by a pig endothelial cell line inhibits lysis by human serum

Xenotransplantation

Volumn 13, Issue 1, 2006, Pages 75-79

  Manzi, Lorna ^a   Montaño, Ramón ^a   Abad, María Jesús ^a   Arsenak, Miriam ^a   Romano, Egidio ^a   Taylor, Peter ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Complement; Complement receptor type 1; Endothelial cells; Pig; Xenotransplantation

Indexed keywords

CD59 ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT REGULATORY PROTEIN; DECAY ACCELERATING FACTOR; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL PROTECTION; COMPLEMENT ACTIVATION; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; ENDOTHELIUM CELL; GENETIC MANIPULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPERACUTE GRAFT REJECTION; NONHUMAN; PRIORITY JOURNAL; SERUM; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL DEATH; CELL LINE; COMPLEMENT ACTIVATION; ENDOTHELIAL CELLS; GRAFT REJECTION; HUMANS; RECEPTORS, COMPLEMENT; RECEPTORS, COMPLEMENT 3B; SERUM; SWINE; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 33645992107     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2005.00265.x     Document Type: Article

References (27)

1. Galili U Rachmilewitz EA Peleg A Flechner I. A unique natural human IgG antibody with anti-alpha-galactosyl specificity J Exp Med 1984 160 1519
2. Dalmasso AP Vercellotti GM Fischel RJ et al Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients Am J Pathol 1992 140 1157
3. Dalmasso AP Vercellotti GM Platt JL Bach FH. Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Potential for prevention of xenograft hyperacute rejection Transplantation 1991 52 530
4. Kolber-Simonds D Lai L Watt SR et al Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations Proc Natl Acad Sci U S A 2004 101 7335
5. Kuwaki K Tseng YL Dor FJ et al Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors initial experience Nat Med 2005 11 29
6. Cozzi E White DJ. The generation of transgenic pigs as potential organ donors for humans Nat Med 1995 1 964
7. Diamond LE Quinn CM Martin MJ et al A human CD46 transgenic pig model system for the study of discordant xenotransplantation Transplantation 2001 71 132
8. Fodor WL Williams BL Matis LA et al Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection Proc Natl Acad Sci U S A 1994 91 11153
9. Yeh CG Marsh HC Jr. Carson GR et al Recombinant soluble human complement receptor type 1 inhibits inflammation in the reversed passive arthus reaction in rats J Immunol 1991 146 250
10. Piddlesden SJ Storch MK Hibbs M et al Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis J Immunol 1994 152 5477
11. Dreja H Annenkov A Chernajovsky Y. Soluble complement receptor 1 (CD35) delivered by retrovirally infected syngeneic cells or by naked DNA injection prevents the progression of collagen-induced arthritis Arthritis Rheum 2000 43 1698
12. Heckl-Ostreicher B Wosnik A Kirschfink M. Protection of porcine endothelial cells from complement-mediated cytotoxicity by the human complement regulators CD59, C1 inhibitor, and soluble complement receptor type 1 analysis in a pig-to-human in vitro model relevant to hyperacute xenograft rejection Transplantation 1996 62 1693
13. Azimzadeh A Zorn GL 3rd. Blair KSA et al Hyperacute lung rejection in the pig-to-human model. 2. Synergy between soluble and membrane complement inhibition Xenotransplantation 2003 10 120
14. Pruitt SK Kirk AD Bollinger RR et al The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts Transplantation 1994 57 363
15. Candinas D Lesnikoski BA Robson SC et al Effect of repetitive high-dose treatment with soluble complement receptor type 1 and cobra venom factor on discordant xenograft survival Transplantation 1996 62 336
16. Candinas D Lesnikoski BA Robson SC et al Soluble complement receptor type 1 and cobra venom factor in discordant xenotransplantation Transplant Proc 1996 28 581
17. Cooper DK. Xenoantigens and xenoantibodies Xenotransplantation 1998 5 6
18. Schaapherder AF Wolvekamp MC Te Bulte MT et al Porcine islet cells of Langerhans are destroyed by human complement and not by antibody-dependent cell-mediated mechanisms Transplantation 1996 62 29
19. Kroshus TJ Bolman RM 3rd. Dalmasso AP et al Expression of human CD59 in transgenic pig organs enhances organ survival in an ex vivo xenogeneic perfusion model Transplantation 1996 61 1513
20. Fecke W Long J Richards A Harrison R. Protection of hDAF-transgenic porcine endothelial cells against activation by human complement role of the membrane attack complex Xenotransplantation 2002 9 97
21. Mccurry KR Kooyman DL Alvarado CG et al Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury [see comments] Nat Med 1995 1 423
22. Mollnes TE Fiane AE. Perspectives on complement in xenotransplantation Mol Immunol 2003 40 135
23. Dalmasso AP Platt JL. Prevention of complement-mediated activation of xenogeneic endothelial cells in an in vitro model of xenograft hyperacute rejection by C1 inhibitor Transplantation 1993 56 1171
24. Lam TT Hausen B Hook L et al The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts Xenotransplantation 2005 12 20
25. Yazdanbakhsh K Kang S Tamasauskas D Sung D Scaradavou A. Complement receptor 1 inhibitors for prevention of immune-mediated red cell destruction potential use in transfusion therapy Blood 2003 101 5046
26. Makrides SC. Therapeutic inhibition of the complement system Pharmacol Rev 1998 50 59
27. Rioux P. TP-10 (AVANT Immunotherapeutics) Curr Opin Invest Drugs 2001 2 364