Alpha-tocopherol (Vitamin E) induces rapid, nonsustained proliferation in cultured rat microglia

GLIA

Volumn 53, Issue 6, 2006, Pages 669-674

  Flanary, Barry E ^a   Streit, Wolfgang J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Alpha lipoic acid; GM CSF; Senescence; Telomerase; Telomere

Indexed keywords

ALPHA TOCOPHEROL; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1BETA; TELOMERASE; THIOCTIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN FUNCTION; CELL ACTIVATION; CELL PROLIFERATION; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVITY; IMMUNE RESPONSE; MICROGLIA; MITOSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TELOMERE; VITAMIN SUPPLEMENTATION;

ALPHA-TOCOPHEROL; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; BRAIN; BRAIN INJURIES; CELL AGING; CELL DIVISION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; GLIOSIS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-1; MICROGLIA; MITOGENS; RATS; RATS, SPRAGUE-DAWLEY; TELOMERASE; TELOMERE; THIOCTIC ACID; UP-REGULATION;

EID: 33645968972     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20313     Document Type: Article

References (39)

1. Abdel-Aziz W, Jiang HY, Hickey RJ, Malkas LH. 2000. Ara-C affects formation of cancer cell DNA synthesome replication intermediates. Cancer Chemother Pharmacol 45:312-319.
2. Azzi A, Gysin R, Kempna P, Munteanu A, Negis Y, Villacorta L, Visarius T, Zingg JM. 2004. Vitamin E mediates cell signaling and regulation of gene expression. Ann NY Acad Sci 1031:86-95.
3. Behl C, Moosmann B. 2002. Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach. Free Radic Biol Med 33:182-191.
4. Bendich A. 1988. Vitamin E and immune functions. Basic Life Sci 49:615-620.
5. Devi SA, Kiran TR. 2004. Regional responses in antioxidant system to exercise training and dietary vitamin E in aging rat brain. Neurobiol Aging 25:501-508.
6. Flanary BE, Streit WJ. 2003. Telomeres shorten with age in rat cerebellum and cortex in vivo. J Anti-Aging Med 6:299-308.
7. Flanary BE, Streit WJ. 2004. Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes. Glia 45:75-88.
8. Geller HM, Cheng KY, Goldsmith NK, Romero AA, Zhang AL, Morris EJ, Grandison L. 2001. Oxidative stress mediates neuronal DNA damage and apoptosis in response to cytosine arabinoside. J Neurochem 78:265-275.
9. Giulian D, Ingeman JE. 1988. Colony-stimulating factors as promoters of ameboid microglia. J Neurosci 8:4707-4717.
10. Graeber MB, Tetzlaff W, Streit WJ, Kreutzberg GW. 1988. Microglial cells but not astrocytes undergo mitosis following facial nerve axotomy. Neurosci Lett 85:317-321.
11. Halliwell B, Gutteridge JMC. 1985. Oxygen radicals in the nervous system. Trends Neurosci 8:22-26.
12. Heppner FL, Roth K, Nitsch R, Hailer NP. 1998. Vitamin E induces ramification and downregulation of adhesion molecules in cultured microglial cells. Glia 22:180-188.
13. Kanno S, Higurashi A, Watanabe Y, Shouji A, Asou K, Ishikawa M. 2004. Susceptibility to cytosine arabinoside (Ara-C)-induced cytotoxicity in human leukemia cell lines. Toxicol Lett 152:149-158.
14. Lassmann H, Bancher C, Breitschopf H, Wegiel J, Bobinski M, Jellinger K, Wisniewski HM. 1995. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol 89:35-41.
15. Leeds P, Leng Y, Chalecka-Franaszek E, Chuang DM. 2005. Neurotrophins protect against cytosine arabinoside-induced apoptosis of immature rat cerebellar neurons. Neurochem Int 46:61-72.
16. Li Y, Liu L, Barger SW, Mrak RE, Griffin WS. 2001. Vitamin E suppression of microglial activation is neuroprotective. J Neurosci Res 66:163-170.
17. McGeer PL, Itagaki S, Tago H, McGeer EG. 1987. Reactive microglia in patients with senile dementia of the Alzheimer's type are positive for the histocompatibility glycoprotein HLA-DR. Neurosci Lett 79:195-200.
18. McGeer PL, McGeer EG. 2001. Inflammation, autotoxicity and Alzheimer disease. Neurobiol Aging 22:799-809.
19. Meydani SN, Meydani M, Verdon CP, Shapiro AA, Blumberg JB, Hayes KC. 1986. Vitamin E supplementation suppresses prostaglandin E1(2) synthesis and enhances the immune response of aged mice. Mech Ageing Dev 34:191-201.
20. Miller JS, Gavino VC, Ackerman GA, Sharma HM, Milo GE, Geer JC, Cornwell DG. 1980. Triglycerides, lipid droplets, and lysosomes in aorta smooth muscle cells during the control of cell proliferation with polyunsaturated fatty acids and vitamin E. Lab Invest 42:495-506.
21. Ogru E, Libinaki R, Gianello R, West S, Munteanu A, Zingg JM, Azzi A. 2004. Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammation. Ann NY Acad Sci 1031:405-411.
22. Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ, the Alzheimer's Disease Cooperative Study Group. 2005. Vitamin E, donepezil for the treatment of mild cognitive impairment. N Engl J Med 352:2379-2388.
23. Raivich G, Gehrmann J, Kreutzberg GW. 1991. Increase of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor receptors in the regenerating rat facial nucleus. J Neurosci Res 30:682-686.
24. Raivich G, Moreno-Flores MT, Moller JC, Kreutzberg GW. 1994. Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse. Eur J Neurosci 6:1615-1618.
25. Rimbach G, Minihane AM, Majewicz J, Fischer A, Pallauf J, Virgli F, Weinberg PD. 2002. Regulation of cell signalling by vitamin E. Proc Nutr Soc 61:415-425.
26. Rogers J, Luber-Narod J, Styren SD, Civin WH. 1988. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol Aging 9:339-349.
27. Roy RM, Petrella M, Ross WM. 1991. Modification of mitogen-induced proliferation of murine splenic lymphocytes by in vitro tocopherol. Immunopharmacol Immunotoxicol 13:531-550.
28. Sakai S, Moriguchi S. 1997. Long-term feeding of high vitamin E diet improves the decreased mitogen response of rat splenic lymphocytes with aging. J Nutr Sci Vitaminol (Tokyo) 43:113-122.
29. Saleen A, Datta R, Yuan ZM, Kharbanda S, Kufe D. 1995. Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents. Cell Growth Differ 6:1651-1658.
30. Scholich H, Murphy ME, Sies H. 1989. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol. Biochem Biophys Acta 1101:256-261.
31. Sheng JG, Mrak RE, Griffin WS. 1998. Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol 95:229-234.
32. Socci DJ, Crandall BM, Arendash GW. 1995. Chronic antioxidant treatment improves the cognitive performance of aged rats. Brain Res 693:88-94.
33. Stoyanovsky DA, Goldman R, Darrow RM, Organisciak DT, Kagan VE. 1995. Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with exogenous dihydrolipoic acid. Curr Eye Res 14:181-189.
34. Streit WJ. 2002. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40:133-139.
35. Streit WJ. 2005. Microglia and neuroprotection: implications for Alzheimer's disease. Brain Res Brain Res Rev 48:234-239.
36. Streit WJ, Hurley SD, McGraw TS, Semple-Rowland SL. 2000. Comparative evaluation of cytokine profiles and reactive gliosis supports a critical role for interleukin-6 in neuron-glia signaling during regeneration. J Neurosci Res 61:10-20.
37. Streit WJ, Sammons NW, Kuhns AJ, Sparks DL. 2004. Dystrophic microglia in the aging human brain. Glia 45:208-212.
38. Streit WJ, Sparks DL. 1997. Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits. J Mol Med 75:130-138.
39. Tengerdy RP. 1989. Vitamin E, immune response, and disease resistance. Ann NY Acad Sci 570:335-344.