Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia

Clinical Toxicology

Volumn 44, Issue 2, 2006, Pages 173-175

  Chen, Chun Yu ^a   Wang, Feng Lin ^a   Lin, Chih Chuan ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NONE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYCHLOROQUINE; ISOPRENALINE; LIDOCAINE; MAGNESIUM SULFATE; PREDNISOLONE; THEOPHYLLINE; ANTIRHEUMATIC AGENT;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; DISEASE COURSE; ELECTROCARDIOGRAM; FEMALE; HEART VENTRICLE ARRHYTHMIA; HUMAN; QT PROLONGATION; SYSTEMIC LUPUS ERYTHEMATOSUS; TORSADE DES POINTES; AGED; CHEMICALLY INDUCED DISORDER; ELECTROCARDIOGRAPHY; HEART VENTRICLE EXTRASYSTOLE; LONG QT SYNDROME; TIME;

AGED; ANTIRHEUMATIC AGENTS; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; HYDROXYCHLOROQUINE; LONG QT SYNDROME; LUPUS ERYTHEMATOSUS, SYSTEMIC; TIME FACTORS; VENTRICULAR PREMATURE COMPLEXES;

EID: 33645960953     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650500514558     Document Type: Article

References (8)

1. Yap YG, Camm J. Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause QT prolongation. Br Med J 2000; 320(7243):1158-1159.
2. Curtis LH, Ostbye T, Sendersky V, Hutchison S, Allen LaPointe NM, Al-Khatib SM, Usdin Yasuda S, Dans PE, Wright A, Califf RM, Woosley RL, Schulman KA. Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients. Am J Med 2003; 114(2):135-141.
3. Marquardt K, Albertson TE. Treatment of hydroxychloroquine overdose. Am J Emerg Med 2001; 19(5):420-424.
4. Jordan P, Brookes JG, Nikolic G, Le Couteur DG. Hydroxychloroquine overdose: toxicokinetics and management. J Toxicol, Clin Toxicol 1999; 37(7):861-864.
5. Isbister GK, Dawson A, Whyte IM. Hydroxychloroquine overdose: a prospective case series. Am J Emerg Med 2002; 20(4):377-378.
6. Tett S, Cutler D, Day R. Antimalarials in rheumatic diseases. Clin Rheumatol 1990; 4(3):467-489.
7. Furst DE. Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases. Lupus 1996; 5(Suppl 1): S11-S15.
8. Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Car diovascular Care. Part 6: advanced cardiovascular life support: section 1: Introduction to ACLS 2000: overview of recommended changes in ACLS from the guidelines 2000 conference. The American Heart Association in collaboration with the International Liaison Committee on Resuscitation. Circulation 2000; 102(8 Suppl):I86-189.