Hydroxychloroquine overdose: Toxicokinetics and management

Journal of Toxicology - Clinical Toxicology

Volumn 37, Issue 7, 1999, Pages 861-864

  Jordan, Peter ^a   Brookes, Jennifer G ^a   Nikolic, George ^a   Le Couteur, David G ^b  

^a CANBERRA HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; DIAZEPAM; HYDROXYCHLOROQUINE; MAGNESIUM SULFATE; POLYGELINE; POTASSIUM;

ADULT; ARTICLE; CASE REPORT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG OVERDOSE; ENDOTRACHEAL INTUBATION; FEMALE; HEART VENTRICLE TACHYCARDIA; HUMAN; HYPOKALEMIA; HYPOTENSION; SUICIDE ATTEMPT; TOXICOKINETICS;

ADOLESCENT; ANTIMALARIALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROCARDIOGRAPHY; FEMALE; HALF-LIFE; HUMANS; HYDROXYCHLOROQUINE; LUPUS ERYTHEMATOSUS, SYSTEMIC; OVERDOSE; SUICIDE, ATTEMPTED; VENTRICULAR PREMATURE COMPLEXES;

EID: 0033400269     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.1081/CLT-100102466     Document Type: Article

References (17)

1. McChesney EW. Animal toxicity and pharmacokinetics of hydroxychloroquine sulfate. Am J Med 1983;75(suppl 1A):11-18.
2. Bonnichsen R, Maehly AC. Two fatal poisonings by chloroquine and by hydroxychloroquine. J Forensic Sci Soc 1965;5:201-202.
3. Dalley RA, Hainsworth D. Fatal Plaquenil poisoning. J Forensic Sci Soc 1965;5:99-101.
4. de Jong-Strakova Z, Blaauw AA, van der Linden S, Ferweda J. Acute hydroxychloroquine poisoning: Recommendations for treatment. Tijdschr Geneesk 1990;134: 2445-2446.
5. Kemmenoe AV. An infant fatality due to hydroxychloroquine poisoning. J Anal Toxicol 1990;14:186-188.
6. Graham JD. An overdose of "Plaquenil." Br Med J 1960;i:1256.
7. Miller D, Fiechtner J. Hydroxychloroquine overdosage. J Rheumatol 1989;16:142.
8. Palatnick W, Meatherall R, Sitar D, Tenebein M. Hydroxychloroquine kinetics after overdose (abstract). J Toxicol Clin Toxicol 1997;35:496.
9. Pruchnicki SA, Good TF, Walson PD. Severe hydroxychloroquine poisoning reversed with diazepam (abstract). J Toxicol Clin Toxicol 1997;34:582.
10. Anonymous. Overdose of hydroxychloroquine. Pharm J 1963;June:504.
11. Riou B, Barriot P, Rimailho A, Baud FL. Treatment of severe chloroquine poisoning. N Engl J Med 1988;318:1-6.
12. Clemessy JL, Taboulet P, Hoffman JR et al. Treatment of acute chloroquine poisoning: A 5-year experience. Crit Care Med 1996;24:1189-1195.
13. Miller DR, Shoukry KW, Khalil KW, Nygard GA. Steady state pharmacokinetics of hydroxychloroquine in rheumatoid arthritis patients. DICP Ann Pharmacother 1991; 25:1302-1305.
14. Tett SE, Cutler DJ, Day RO, Brown KF. Bioavailability of hydroxychloroquine tablets in healthy volunteers. Br J Clin Pharmacol 1989;27:771-779.
15. Jaeger A, Sauder P, Kopfershmitt J, Flesch F. Clinical features and management of poisoning due to antimalarial drugs. Med Toxicol 1987;2:242-273.
16. Clemessy JL, Favier C, Borron SW, Hantson PE, Vicaut E, Baud FJ. Hypokalemia related to acute chloroquine ingestion. Lancet 1995;346:877-880.
17. Kunze K, Kauerz V, Scholdt A. Drug induced myopathy by hydroxychloroquine. Vet Hum Toxicol 1987;29(suppl 2):59-60.