Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage II and III rectal adenocarcinoma: The Freiburg experience (1989-2002)

World Journal of Gastroenterology

Volumn 12, Issue 12, 2006, Pages 1849-1858

  Weissenberger, Christian ^a   Geissler, Michael ^b   Otto, Florian ^a   Barke, Annette ^a   Henne, Karl ^a   von Plehn, Georg ^a   Rein, Alex ^a   Müller, Christine ^a   Bartelt, Susanne ^a   Henke, Michael ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b KLINIKUM ESSLINGEN   (Germany)

Author keywords

Adjuvant radiochemotherapy; Adjuvant radiotherapy; Anemia; Prognostic factor; Rectal cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CARCINOEMBRYONIC ANTIGEN; FLUOROURACIL; FOLINIC ACID; MITOMYCIN C;

ADULT; AGED; ANEMIA; ARTICLE; CANCER ADJUVANT THERAPY; CANCER PATIENT; CANCER RELAPSE; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DIARRHEA; DISEASE FREE SURVIVAL; DYSURIA; EXPERIENCE; FEMALE; FOLLOW UP; HUMAN; HYPERHEMOGLOBINEMIA; KAPLAN MEIER METHOD; LOG RANK TEST; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; POSTOPERATIVE PERIOD; PREDICTION; PREOPERATIVE PERIOD; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; QUANTITATIVE ANALYSIS; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM CARCINOMA; SEX DIFFERENCE; SKIN MANIFESTATION; STANDARDIZATION; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; UNIVARIATE ANALYSIS;

EID: 33645957916     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i12.1849     Document Type: Article

References (45)

1. Saltz LB, Minsky B. Adjuvant therapy of cancers of the colon and rectum. Surg Clin North Am 2002; 82: 1035-1058
2. Kachnic LA, Willett CG. Radiation therapy in the management of rectal cancer. Curr Opin Oncol 2001; 13: 300-306
3. Radiation therapy and fluorouracil with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. Gastrointestinal Tumor Study Group. J Clin Oncol 1992; 10: 549-557
4. Krook JE, Moertel CG, Gunderson LL, Wieand HS, Collins RT, Beart RW, Kubista TP, Poon MA, Meyers WC, Mailliard JA. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 1991; 324: 709-715
5. Henke M, Sindlinger F, Ikenberg H, Gerds T, Schumacher M. Blood hemoglobin level and treatment outcome of early breast cancer. Strahlenther Onkol 2004; 180: 45-51
6. Frommhold H, Guttenberger R, Henke M. The impact of blood hemoglobin content on the outcome of radiotherapy. The Freiburg experience. Strahlenther Onkol 1998; 174 Suppl 4: 31-34
7. Kwok H, Bissett IP, Hill GL. Preoperative staging of rectal cancer. Int J Colorectal Dis 2000; 15: 9-20
8. Phang PT, MacFarlane JK, Taylor RH, Cheifetz RE, Davis N, Hay JH, McGregor G, Speers C, Sullivan BJ, Pitts J, Coldman AJ. Effects of positive resection margin and tumor distance from anus on rectal cancer treatment outcomes. Am J Surg 2002; 183: 504-508
9. Van Cutsem E. Report of the expert opinion on the treatment of rectal cancer. 5th International Congress: Perspectives in Colorectal Cancer, 2003
10. Boyle P, McArdle CS and Kerr DJ. Colorectal Cancer, 2002
11. Kline RW, Smith AR, Coia LR, Owen JB, Hanlon A, Wallace M, Hanks G. Treatment planning for adenocarcinoma of the rectum and sigmoid: a patterns of care study. PCS Committee. Int J Radiat Oncol Biol Phys 1997; 37: 305-311
12. NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA 1990; 264: 1444-1450
13. Coia LR, Gunderson LL, Haller D, Hoffman J, Mohiuddin M, Tepper JE, Berkey B, Owen JB, Hanks GE. Outcomes of patients receiving radiation for carcinoma of the rectum. Results of the 1988-1989 patterns of care study. Cancer 1999; 86: 1952-1958
14. Deutsche Krebsgesellschaft. Colon carcinoma and rectal carcinoma. Interdisciplinary guidelines. Onkologe 1999; 5: 348-358
15. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457-481
16. Peto R, Peto J. Asymptocally efficient rank invariant test procedures. J R Stat Soc 1972; A 135: 185-206
17. Cox DR. Regression models and life tables. J R Stat Soc 1972; B 34: 187-220
18. Nakayama T, Watanabe M, Teramoto T, Kitajima M. Slope analysis of CA19-9 and CEA for predicting recurrence in colorectal cancer patients. Anticancer Res 1997; 17: 1379-1382
19. Gunderson LL, Sargent DJ, Tepper JE, O'Connell MJ, Allmer C, Smalley SR, Martenson JA, Haller DG, Mayer RJ, Rich TA, Ajani JA, Macdonald JS, Goldberg RM. Impact of T and N substage on survival and disease relapse in adjuvant rectal cancer: a pooled analysis. Int J Radiat Oncol Biol Phys 2002; 54: 386-396
20. Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004; 351: 1731-1740
21. Gnant M. Impact of participation in randomized clinical trials on survival of women with early-stage breast cancer - an analysis of 7985 patients. Proc Am Soc Oncol 2000; 19: 287 [http://www.asco.org/ac/ 1,1003,_12-002636-00_18-002-00_19-00201906,00.asp]
22. Lee JH, Lee JH, Ahn JH, Bahng H, Kim TW, Kang YK, Lee KH, Kim JC, Yu CS, Kim JH, Aln SD, Kim WK, Kim SH, Lee JS. Randomized trial of postoperative adjuvant therapy in stage II and III rectal cancer to define the optimal sequence of chemotherapy and radiotherapy: a preliminary report. J Clin Oncol 2002; 20: 1751-1758
23. Arnaud JP, Nordlinger B, Bosset JF, Boes GH, Sahmoud T, Schlag PM, Pene F. Radical surgery and postoperative radiotherapy as combined treatment in rectal cancer. Final results of a phase III study of the European Organization for Research and Treatment of Cancer. Br J Surg 1997; 84: 352-357
24. McCall JL, Cox MR, Wattchow DA. Analysis of local recurrence rates after surgery alone for rectal cancer. Int J Colorectal Dis 1995; 10: 126-132
25. Phillips RK, Hittinger R, Blesovsky L, Fry JS, Fielding LP. Local recurrence following 'curative' surgery for large bowel cancer: I. The overall picture. Br J Surg 1984; 71: 12-16
26. Harnsberger JR, Vernava VM 3rd, Longo WE. Radical abdominopelvic lymphadenectomy: historic perspective and current role in the surgical management of rectal cancer. Dis Colon Rectum 1994; 37: 73-87
27. Enker WE, Merchant N, Cohen AM, Lanouette NM, Swallow C, Guillem J, Paty P, Minsky B, Weyrauch K, Quan SH. Safety and efficacy of low anterior resection for rectal cancer: 681 consecutive cases from a specialty service. Ann Surg 1999; 230: 544-52; discussion 552-554
28. MacFarlane JK, Ryall RD, Heald RJ. Mesorectal excision for rectal cancer. Lancet 1993; 341: 457-460
29. Tang R, Wang JY, Chen JS, Chang-Chien CR, Lin SE, Leung S, Fan HA. Postoperative adjuvant radiotherapy in Astler-Coller stages B2 and C rectal cancer. Dis Colon Rectum 1992; 35: 1057-1065
30. Stocchi L, Nelson H, Sargent DJ, O'Connell MJ, Tepper JE, Krook JE, Beart R Jr. Impact of surgical and pathologic variables in rectal cancer: a United States community and cooperative group report. J Clin Oncol 2001; 19: 3895-3902
31. Martijn H, de Neve W, Lybeert ML, Crommelin MA, Ribot JG. Adjuvant postoperative radiotherapy for adenocarcinoma of the rectum and rectosigmoid. A retrospective analysis of locoregional control, survival, and prognostic factors on 178 patients. Am J Clin Oncol 1995; 18: 277-281
32. Kuru B, Camlibel M, Dinc S, Erdem E, Alagol H. Prognostic factors affecting local recurrence and survival for operable rectal cancers. J Exp Clin Cancer Res 2002; 21: 329-335
33. Luna-Perez P, Rodriguez-Ramirez S, Vega J, Sandoval E, Labastida S. Morbidity and mortality following abdominoperineal resection for low rectal adenocarcinoma. Rev Invest Clin 2001; 53: 388-395
34. Rinkus KM, Russell GB, Levine EA. Prognostic significance of nodal disease following preoperative radiation for rectal adenocarcinoma. Am Surg 2002; 68: 482-487
35. Link KH, Staib L, Schatz M, Suhr P, Rottinger E, Beger HG. Adjuvant radiochemotherapy - what is the patients benefit? Langenbecks Arch Surg 1998; 383: 416-426
36. Kapiteijn E, van de Velde CJ. Developments and quality assurance in rectal cancer surgery. Eur J Cancer 2002; 38: 919-936
37. Tepper JE, O'Connell M, Niedzwiecki D, Hollis DR, Benson AB 3rd, Cummings B, Gunderson LL, Macdonald JS, Martenson JA, Mayer RJ. Adjuvant therapy in rectal cancer: analysis of stage, sex, and local control - final report of intergroup 0114. J Clin Oncol 2002; 20: 1744-1750
38. Moynihan C. Men, women, gender and cancer. Eur J Cancer Care (Engl) 2002; 11: 166-172
39. Sargent DJ, Goldberg RM, Jacobson SD, Macdonald JS, Labianca R, Haller DG, Shepherd LE, Seitz JF, Francini G. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 2001; 345: 1091-1097
40. Popescu RA, Norman A, Ross PJ, Parikh B, Cunningham D. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 1999; 17: 2412-2418
41. Reiter W, Stieber P, Reuter C, Nagel D, Lau-Werner U, Pahl H, Fateh-Moghadam A. Preoperative serum levels of CEA and CA 19-9 and their prognostic significance in colorectal carcinoma. Anticancer Res 1997; 17: 2935-2938
42. Nelson RL. The usefulness of carcinoembryonic antigen in postoperative colorectal cancer patients. Dis Colon Rectum 1997; 40: 866-867
43. Behbehani AI, Al-Sayer H, Farghaly M, Kanawati N, Mathew A, al-Bader A, Van Dalen A. Prognostic significance of CEA and CA 19-9 in colorectal cancer in Kuwait. Int J Biol Markers 2000; 15: 51-55
44. Frykholm GJ, Glimelius B, Pahlman L. Preoperative or postoperative irradiation in adenocarcinoma of the rectum: final treatment results of a randomized trial and an evaluation of late secondary effects. Dis Colon Rectum 1993; 36: 564-572
45. Pahlman L, Glimelius B Pre-operative and post-operative radiotherapy and rectal cancer. World J Surg 1992; 16: 858-865