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Volumn 20, Issue SUPPL. 3, 2005, Pages

CYP2C19 genotype and the PPIs - Focus on rabeprazole

Author keywords

Acid related disorders; Consistent inhibition; CYP4502C19 genetic polymorphism; Rabeprazole

Indexed keywords

AMOXICILLIN; CLARITHROMYCIN; CYTOCHROME P450 2C19; METRONIDAZOLE; PROTON PUMP INHIBITOR; RABEPRAZOLE; 2 [[(2 PYRIDYL)METHYL]SULFINYL]BENZIMIDAZOLE DERIVATIVE; ADENOSINE TRIPHOSPHATASE; ANTIULCER AGENT; BENZIMIDAZOLE DERIVATIVE; CYP2C19 PROTEIN, HUMAN; DRUG DERIVATIVE; MIXED FUNCTION OXIDASE; OMEPRAZOLE; PROTON PUMP; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNSPECIFIC MONOOXYGENASE;

EID: 33645923112     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2005.04167.x     Document Type: Conference Paper
Times cited : (41)

References (40)
  • 1
    • 23844468166 scopus 로고    scopus 로고
    • Proton pump inhibitors: Update on their role in acid-related gastrointestinal diseases
    • Robinson M. Proton pump inhibitors: update on their role in acid-related gastrointestinal diseases. Int. J. Clin. Pract. 2005; 59: 709-15.
    • (2005) Int. J. Clin. Pract. , vol.59 , pp. 709-715
    • Robinson, M.1
  • 2
    • 0034792584 scopus 로고    scopus 로고
    • Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
    • Goldstein JA. Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br. J. Clin. Pharmacol. 2001; 52: 349-55.
    • (2001) Br. J. Clin. Pharmacol. , vol.52 , pp. 349-355
    • Goldstein, J.A.1
  • 3
    • 0032807774 scopus 로고    scopus 로고
    • Review article: Cytochrome P450 and the metabolism of proton pump inhibitors - Emphasis on rabeprazole
    • Ishizaki T, Horai Y. Review article: cytochrome P450 and the metabolism of proton pump inhibitors - emphasis on rabeprazole. Aliment. Pharmacol. Ther. 1999; 13 (Suppl. 3): 27-36.
    • (1999) Aliment. Pharmacol. Ther. , vol.13 , Issue.SUPPL. 3 , pp. 27-36
    • Ishizaki, T.1    Horai, Y.2
  • 4
    • 0034958073 scopus 로고    scopus 로고
    • New-generation proton pump inhibitors: Overcoming the limitations of early-generation agents
    • Robinson M. New-generation proton pump inhibitors: overcoming the limitations of early-generation agents. Eur J. Gastroenterol. Hepatol. 2001; 13 (Suppl. 1): S43-7.
    • (2001) Eur J. Gastroenterol. Hepatol. , vol.13 , Issue.SUPPL. 1
    • Robinson, M.1
  • 5
    • 0034950961 scopus 로고    scopus 로고
    • Shortcomings of the first-generation proton pump inhibitors
    • Tytgat GN. Shortcomings of the first-generation proton pump inhibitors. Eur. J. Gastroenterol. Hepatol. 2001; 13 (Suppl. 1): S29-33.
    • (2001) Eur. J. Gastroenterol. Hepatol. , vol.13 , Issue.SUPPL. 1
    • Tytgat, G.N.1
  • 7
    • 0030444707 scopus 로고    scopus 로고
    • Genotyping of Smephenytoin 4′-hydroxylation in an extended Japanese population
    • Kubota T, Chiba K, Ishizaki T. Genotyping of Smephenytoin 4′-hydroxylation in an extended Japanese population. Clin. Pharmacol. Ther. 1996; 60: 661-6.
    • (1996) Clin. Pharmacol. Ther. , vol.60 , pp. 661-666
    • Kubota, T.1    Chiba, K.2    Ishizaki, T.3
  • 9
    • 0036020526 scopus 로고    scopus 로고
    • Proton pump inhibitors - Differences emerge in hepatic metabolism
    • McColl KE, Kennerley P. Proton pump inhibitors - differences emerge in hepatic metabolism. Dig. Liver Dis. 2002; 34: 461-7.
    • (2002) Dig. Liver Dis. , vol.34 , pp. 461-467
    • McColl, K.E.1    Kennerley, P.2
  • 10
    • 9944249092 scopus 로고    scopus 로고
    • Review article: The pharmacodynamics and pharmacokinetics of proton pump inhibitors - Overview and clinical implications
    • Robinson M. Review article: the pharmacodynamics and pharmacokinetics of proton pump inhibitors - overview and clinical implications. Aliment. Pharmacol. Ther. 2004; 20: (Suppl. 6): 1-10.
    • (2004) Aliment. Pharmacol. Ther. , vol.20 , Issue.SUPPL. 6 , pp. 1-10
    • Robinson, M.1
  • 11
    • 84895593362 scopus 로고    scopus 로고
    • [Cited 01 August 2005] Available from
    • Rabeprazole US Package Insert. [Cited 01 August 2005] Available from: http://www.aciphex.com/aciphexpi.pdf
    • Rabeprazole US Package Insert
  • 13
    • 0032716358 scopus 로고    scopus 로고
    • Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world
    • Xie HG, Stein CM, Kim RB, Wilkinson GR, Flockhart DA, Wood AJ. Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world. Pharmacogenetics 1999; 9: 539-49.
    • (1999) Pharmacogenetics , vol.9 , pp. 539-549
    • Xie, H.G.1    Stein, C.M.2    Kim, R.B.3    Wilkinson, G.R.4    Flockhart, D.A.5    Wood, A.J.6
  • 14
    • 0034752833 scopus 로고    scopus 로고
    • Genetic differences in CYP2C19 single nucleotide polymorphisms among four Asian populations
    • Yamada S, Onda M, Kato S et al. Genetic differences in CYP2C19 single nucleotide polymorphisms among four Asian populations. J. Gastroenterol. 2001; 36: 669-72.
    • (2001) J. Gastroenterol. , vol.36 , pp. 669-672
    • Yamada, S.1    Onda, M.2    Kato, S.3
  • 16
    • 0036260110 scopus 로고    scopus 로고
    • Analysis of the CYP2C19 polymorphism in a Northeastern Thai population
    • Tassaneeyakul W, Tawalee A, Tassaneeyakul W et al. Analysis of the CYP2C19 polymorphism in a Northeastern Thai population. Pharmacogenetics 2002; 12: 221-5.
    • (2002) Pharmacogenetics , vol.12 , pp. 221-225
    • Tassaneeyakul, W.1    Tawalee, A.2    Tassaneeyakul, W.3
  • 17
    • 0030904031 scopus 로고    scopus 로고
    • Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations
    • Goldstein JA, Ishizaki T, Chiba K et al. Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations. Pharmacogenetics 1997; 7: 59-64.
    • (1997) Pharmacogenetics , vol.7 , pp. 59-64
    • Goldstein, J.A.1    Ishizaki, T.2    Chiba, K.3
  • 18
    • 0029042294 scopus 로고
    • The mephenytoin (cytochrome P450 2C 19) and dextromethorphan (cytochrome P450 2D6) polymorphisms in Saudi Arabians and Filipinos
    • Evans DA, Krahn P, Narayanan N. The mephenytoin (cytochrome P450 2C 19) and dextromethorphan (cytochrome P450 2D6) polymorphisms in Saudi Arabians and Filipinos. Pharmacogenetics 1995; 5: 64-71.
    • (1995) Pharmacogenetics , vol.5 , pp. 64-71
    • Evans, D.A.1    Krahn, P.2    Narayanan, N.3
  • 20
    • 0036219836 scopus 로고    scopus 로고
    • CYP2C19 genotype and S-mephenytoin 4'-hydroxylation phenotype in a Chinese Dai population
    • Epub 2002 Feb 22
    • He N, Yan FX, Huang SL et al. CYP2C19 genotype and S-mephenytoin 4'-hydroxylation phenotype in a Chinese Dai population. Eur. J Clin. Pharmacol. 2002; 58: 15-18. Epub 2002 Feb 22.
    • (2002) Eur. J Clin. Pharmacol. , vol.58 , pp. 15-18
    • He, N.1    Yan, F.X.2    Huang, S.L.3
  • 21
    • 3843092910 scopus 로고    scopus 로고
    • Comparison of genetic polymorphism of cytochrome CYP2C19 between men and women in Chinese population
    • Fu LQ, Huang F, Wu DZ, Guo JH. Comparison of genetic polymorphism of cytochrome CYP2C19 between men and women in Chinese population. Yao Xue Xue Bao 2004; 39: 161-3.
    • (2004) Yao Xue Xue Bao , vol.39 , pp. 161-163
    • Fu, L.Q.1    Huang, F.2    Wu, D.Z.3    Guo, J.H.4
  • 22
    • 18144440017 scopus 로고    scopus 로고
    • Genetic variations of S-mephenytoin 4′-hydroxylase (CYP2C19) in the Chinese population
    • Xie HG. Genetic variations of S-mephenytoin 4′-hydroxylase (CYP2C19) in the Chinese population. Life Sci. 2000; 6: PL175-81.
    • (2000) Life Sci. , vol.6
    • Xie, H.G.1
  • 23
    • 2442694261 scopus 로고    scopus 로고
    • Omeprazole as a CYP2C19 marker in Chinese subjects: Assessment of its gene-dose effect and intrasubject variability
    • Yin OQ, Tomlinson B, Chow AH, Waye MM, Chow MS. Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability. J. Clin. Pharmacol. 2004; 44: 582-9.
    • (2004) J. Clin. Pharmacol. , vol.44 , pp. 582-589
    • Yin, O.Q.1    Tomlinson, B.2    Chow, A.H.3    Waye, M.M.4    Chow, M.S.5
  • 24
    • 0033757987 scopus 로고    scopus 로고
    • New perspectives in gastric acid suppression: Genetic polymorphisms predict the efficacy of proton pump inhibitors
    • Egan LJ, Murray JA. New perspectives in gastric acid suppression: genetic polymorphisms predict the efficacy of proton pump inhibitors. Dig. Dis. 2000; 18: 58-63.
    • (2000) Dig. Dis. , vol.18 , pp. 58-63
    • Egan, L.J.1    Murray, J.A.2
  • 25
    • 0642379417 scopus 로고    scopus 로고
    • Different contribution of CYP2C19 in the in vitro metabolism of three proton pump inhibitors
    • Kita T, Sakaeda T, Baba T et al. Different contribution of CYP2C19 in the in vitro metabolism of three proton pump inhibitors. Biol. Pharm. Bull. 2003; 26: 386-90.
    • (2003) Biol. Pharm. Bull. , vol.26 , pp. 386-390
    • Kita, T.1    Sakaeda, T.2    Baba, T.3
  • 26
    • 0032586730 scopus 로고    scopus 로고
    • CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans
    • Furuta T, Ohashi K, Kosuge K et al. CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans. Clin. Pharmacol. Ther. 1999; 65: 552-61.
    • (1999) Clin. Pharmacol. Ther. , vol.65 , pp. 552-561
    • Furuta, T.1    Ohashi, K.2    Kosuge, K.3
  • 27
    • 0033851533 scopus 로고    scopus 로고
    • Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism
    • Sagar M, Tybring G, Dahl ML, Bertilsson L, Seensalu R. Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism. Gastroenterology 2000; 119: 670-6.
    • (2000) Gastroenterology , vol.119 , pp. 670-676
    • Sagar, M.1    Tybring, G.2    Dahl, M.L.3    Bertilsson, L.4    Seensalu, R.5
  • 28
    • 0033793888 scopus 로고    scopus 로고
    • CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole
    • Adachi K, Katsube T, Kawamura A et al. CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole. Aliment. Pharmacol. Ther. 2000; 14: 1259-66.
    • (2000) Aliment. Pharmacol. Ther. , vol.14 , pp. 1259-1266
    • Adachi, K.1    Katsube, T.2    Kawamura, A.3
  • 29
    • 18644370131 scopus 로고    scopus 로고
    • Effects of rabeprazole, lansoprazole and omeprazole on intragastric pH in CYP2C19 extensive metabolizers
    • Saitoh T, Fukushima Y, Otsuka H et al. Effects of rabeprazole, lansoprazole and omeprazole on intragastric pH in CYP2C19 extensive metabolizers. Aliment. Pharmacol. Ther. 2002; 16: 1811-17.
    • (2002) Aliment. Pharmacol. Ther. , vol.16 , pp. 1811-1817
    • Saitoh, T.1    Fukushima, Y.2    Otsuka, H.3
  • 30
    • 2142702800 scopus 로고    scopus 로고
    • The effect of proton pump inhibitor on intragastric acidity and it relation to S-mephenytoin hydroxylase genetic polymorphism
    • Wang H, Nie YQ, Dai SJ, She QZ, Li YY. The effect of proton pump inhibitor on intragastric acidity and it relation to S-mephenytoin hydroxylase genetic polymorphism. Zhonghua Nei Ke Za Zhi 2003; 42: 777-80.
    • (2003) Zhonghua Nei Ke Za Zhi , vol.42 , pp. 777-780
    • Wang, H.1    Nie, Y.Q.2    Dai, S.J.3    She, Q.Z.4    Li, Y.Y.5
  • 31
    • 0036633131 scopus 로고    scopus 로고
    • Optimal dose of omeprazole for CYP2C19 extensive metabolizers in anti-Helicobacter pylori therapy: Pharmacokinetic considerations
    • Kita T, Sakaeda T, Aoyama N et al. Optimal dose of omeprazole for CYP2C19 extensive metabolizers in anti-Helicobacter pylori therapy: pharmacokinetic considerations. Biol. Pharm. Bull. 2002; 25: 923-7.
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 923-927
    • Kita, T.1    Sakaeda, T.2    Aoyama, N.3
  • 32
    • 0000140377 scopus 로고    scopus 로고
    • Effect of Genetic Differences in Omeprazole Metabolism on Cure Rates for Helicobacter pylori Infection and Peptic Ulcer
    • Takahisa F, Kyoichi O, Takashi K et al. Effect of Genetic Differences in Omeprazole Metabolism on Cure Rates for Helicobacter pylori Infection and Peptic Ulcer. Ann. Intern. Med. 1998; 129: 1027-30.
    • (1998) Ann. Intern. Med. , vol.129 , pp. 1027-1030
    • Takahisa, F.1    Kyoichi, O.2    Takashi, K.3
  • 33
    • 3342997410 scopus 로고    scopus 로고
    • CYP2C19 polymorphism is a major predictor of treatment failure in white patients by use of lansoprazole-based quadruple therapy for eradication of Helicobacter pylori
    • Schwab M, Schaeffeler E, Klotz U, Treiber G. CYP2C19 polymorphism is a major predictor of treatment failure in white patients by use of lansoprazole-based quadruple therapy for eradication of Helicobacter pylori. Clin. Pharmacol. Ther. 2004; 76: 201-9.
    • (2004) Clin. Pharmacol. Ther. , vol.76 , pp. 201-209
    • Schwab, M.1    Schaeffeler, E.2    Klotz, U.3    Treiber, G.4
  • 34
    • 0034851652 scopus 로고    scopus 로고
    • Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection and CYP2C19 genetic polymorphism
    • Hokari K, Sugiyama T, Kato M et al. Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection and CYP2C19 genetic polymorphism. Aliment. Pharmacol. Ther. 2001; 15: 1479-84.
    • (2001) Aliment. Pharmacol. Ther. , vol.15 , pp. 1479-1484
    • Hokari, K.1    Sugiyama, T.2    Kato, M.3
  • 35
    • 2142686146 scopus 로고    scopus 로고
    • Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection in relation to CYP2C19 genotype
    • Lee SB, Park SJ, Ryu JK et al. Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection in relation to CYP2C19 genotype. Korean J. Gastroenterol. 2003; 42: 468-75.
    • (2003) Korean J. Gastroenterol. , vol.42 , pp. 468-475
    • Lee, S.B.1    Park, S.J.2    Ryu, J.K.3
  • 36
    • 3042806670 scopus 로고    scopus 로고
    • Effect of CYP2C19 genetic polymorphism on treatment efficacy of Helicobacter pylori infection with rabeprazole-based triple therapy in Chinese
    • He XX, Zhao YH, Hao YT. Effect of CYP2C19 genetic polymorphism on treatment efficacy of Helicobacter pylori infection with rabeprazole-based triple therapy in Chinese. Zhonghua Nei Ke Za Zhi 2004; 43: 13-15.
    • (2004) Zhonghua Nei Ke Za Zhi , vol.43 , pp. 13-15
    • He, X.X.1    Zhao, Y.H.2    Hao, Y.T.3
  • 37
    • 0037392311 scopus 로고    scopus 로고
    • The effects of lansoprazole on erosive reflux esophagitis are influenced by CYP2C19 polymorphism
    • Kawamura M, Ohara S, Koike T et al. The effects of lansoprazole on erosive reflux esophagitis are influenced by CYP2C19 polymorphism. Aliment. Pharmacol. Ther. 2003; 17: 965-73.
    • (2003) Aliment. Pharmacol. Ther. , vol.17 , pp. 965-973
    • Kawamura, M.1    Ohara, S.2    Koike, T.3
  • 38
    • 0036795262 scopus 로고    scopus 로고
    • Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole
    • Furuta T, Shirai N, Watanabe F et al. Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole. Clin. Pharmacol. Ther. 2002; 72: 453-60.
    • (2002) Clin. Pharmacol. Ther. , vol.72 , pp. 453-460
    • Furuta, T.1    Shirai, N.2    Watanabe, F.3
  • 39
    • 10644241864 scopus 로고    scopus 로고
    • Review article: Treatment for gastrooesophageal reflux disease - Lifestyle advice and medication
    • Kinoshita Y. Review article: treatment for gastrooesophageal reflux disease - lifestyle advice and medication. Aliment. Pharmacol. Ther. 2004; 20 (Suppl. 8): 19-23.
    • (2004) Aliment. Pharmacol. Ther. , vol.20 , Issue.SUPPL. 8 , pp. 19-23
    • Kinoshita, Y.1
  • 40
    • 4544346554 scopus 로고    scopus 로고
    • The therapeutic effects of rabeprazole at a dose of 10 mg on reflux esophagitis may not be influenced by CYP2C19 polymorphism
    • (Abstract)
    • Ariizumi K, Ohara S, Koike T Sr et al. The therapeutic effects of rabeprazole at a dose of 10 mg on reflux esophagitis may not be influenced by CYP2C19 polymorphism. Gastroenterology 2004; 126 (Suppl. 2): 340 (Abstract).
    • (2004) Gastroenterology , vol.126 , Issue.SUPPL. 2 , pp. 340
    • Ariizumi, K.1    Ohara, S.2    Koike Sr., T.3


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